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According to the latest China Cardiovascular Health and Disease Report 2021 released by the National Cardiovascular Center,Two out of every five deaths due to illness in China died of cardiovascular diseases.

Cardiac rehabilitation is an important means to treat stable cardiovascular diseases and prevent recurrent cardiovascular events. Therefore, it is imperative to fully understand the role of scientific exercise in promoting cardiovascular health and actively carry out cardiac rehabilitation.

A simple analogy:The heart is as important to the human body as the engine is to all kinds of machines and needs regular maintenance.Cardiac rehabilitation is like guiding everyone to use and maintain this engine of human body, ensuring the vitality of the engine, thus improving the quality of life.

Who needs cardiac rehabilitation?

A large number of studies have shown that exercise is beneficial to cardiovascular health.Healthy people and sub-healthy people can reduce the incidence of cardiovascular events by developing active and scientific exercise habits.

Exercise mode:You can choose moderate-intensity aerobic exercise, that is, a rhythmic exercise type that uses large muscle groups of the whole body.Such as swimming, cycling, running and skipping rope.

Tip 1:Everyone’s basal heart rate and peak heart rate vary greatly. For women over 50 years old, men over 40 years old and patients with weak health, an in-depth heart examination should be done before starting exercise rehabilitation."Cardiopulmonary Exercise Test"It can measure everyone’s anaerobic threshold heart rate and peak heart rate, and at the same time, it can more accurately determine the "warning line" of the maximum heart rate during exercise, and judge the heart rate interval corresponding to different exercise intensities.

Tip 2:People who don’t exercise for a long time should followstep by stepThe principle, let the heart and blood vessels gradually adapt, beware of excessive fatigue to increase the risk of cardiovascular events, but also avoid joint muscle damage.

Tip 3:Overweight people should adopt a combination of nutrition and exercise.Controlling energy intake is a necessary means to lose weight, but excessive control of energy will reduce lean body weight (fat-free body weight, the weight of other body components except fat). It is suggested that overweight people lose 5% ~ 10% weight within 6 ~ 12 months. Overweight people need longer aerobic exercise to consume fat, and the recommended aerobic exercise time is 45 ~ 60 minutes. Resistance training can consume more energy. It is better to combine aerobic exercise with resistance exercise.

After the winter, some sports-related sudden deaths have attracted people’s attention, especially the sudden death of young employees of a company in Shanghai outside the gym, which makes people feel awkward. Studies have confirmed that lack of exercise or unreasonable exercise are important factors leading to cardiovascular events. Here are some special precautions about "protecting the heart" in the scientific movement:

oneIf you have chest pain, dizziness, overwork, shortness of breath, excessive sweating, nausea and vomiting and irregular pulse during exercise,Exercise should be stopped immediately.The above symptoms still persist after stopping exercise, especially after stopping exercise for 5 ~ 6 minutes, the heart rate still increases, so you should seek medical advice in time.

2The elderly should choose moderate and low intensity exercise and appropriately increase daily physical activity; You can also carry out traditional rehabilitation training such as Tai Ji Chuan and Baduanjin.The exercise time is relatively shortened or prolonged according to the degree of fatigue,The general exercise duration is 30 ~ 60 minutes/day.

threePatients who are weak in the early stage after cardiac surgery can start with breathing training. Respiratory training can prevent pulmonary complications, promote sputum discharge, effectively increase vital capacity and improve lung function. Adopt abdominal breathing mode, that is, the abdomen bulges after inhaling the nose and adducts after exhaling.When exercising, you can inhale through the nose and exhale through the mouth, take a deep breath and try to prolong the breathing time.The practice of lip-shrinking and exhaling is also an important part of breathing training. It emphasizes that when inhaling, breathe in slowly through the nose, and breathe out after holding your breath a little (similar to blowing candles). The ratio of inhalation time to exhalation time is 1: 2. 10 times per group, 5 groups per day. Some low-intensity exercises, such as walking and limb training, start with 10 minutes/time, 2 ~ 3 times a day, and then gradually increase to the target amount of exercise.

fourNo matter what kind of exercise,The intensity of exercise needs to start from a low intensity,When the individual gradually adapts, he will gradually increase to the target exercise intensity for exercise.

Source: Popular Health magazine

Author: Fan Denghuang, Department of Rehabilitation Medicine, First Affiliated Hospital of Zhejiang University School of Medicine

Audit: Expert of National Health Science Popularization Expert Database

Wang Fang, chief physician, Department of Cardiology, Beijing Hospital

Planning: Wu Weihong Tan Jia

Editor: Yu Yunxi

Author: Guo Mei Jin Xiahui

The historical documentary "Forbidden City" takes the Forbidden City as the clue and the change as the breakthrough point. Through 12 chapters, it tells the important historical events in the 600-year history of Ming and Qing Dynasties, summarizes the gains and losses in historical development, and presents the valuable wisdom of the Chinese nation. It not only emphasizes the integrity of the Chinese nation, but also shows the characteristics of the Chinese nation different from other civilizations, leading the audience to inquire about the vicissitudes of history and pursue the cultural roots.

The documentary "Forbidden City" stands in the perspective of great history, jumping out of the red wall and green tiles to tell the historical situation related to the "Forbidden City". For example, through the comparison of Chinese and foreign civilizations, the characteristics of the Chinese nation can be expressed. The eighth episode of "The Prosperous Age" tells the story of the British envoy Magalny’s visit to China, emphasizing the mutual gifts from China and Britain-Jade Ruyi and Mauser Gun, and pointing out that "Gun and Ruyi represent their respective cultural positions" to illustrate the potential strength and etiquette civilization of the Chinese nation. For example, through the comparison of Chinese and foreign civilizations in the changing situation, we can sum up the historical lessons of the Chinese nation. The sixth episode "Afterglow" introduces the change of silver shortage caused by the exhaustion of silver mines in various countries, and points out that European countries established a rudimentary modern monetary system and financial system due to silver shortage, while the Ming Dynasty experienced economic recession due to silver shortage. This proves the serious harm of arrogance and conservative thinking and summarizes the painful historical lessons.

"As a historical documentary, how to guide the audience to fully, deeply and clearly understand history, respect history, form a sense of history, and drive contemporary people to pursue and inquire about history is a crucial creative proposition." The Forbidden City adopts a popular way to express the charm of Chinese culture. Among them, the most representative is the ingenious combination of cultural relics and history, and the wonderful contrast between historical stories and theme songs. The film is good at seeing the big from the small and showing the macro history through the details of cultural relics. For example, the second episode "Inheritance" uses the horses in Li Gonglin’s "Pasturing in Wei Yan", a cultural relic of the Palace Museum, to show the characteristics of martial arts in the early Ming Dynasty. At the same time, the film also makes the characters in the picture scroll move through modern technology. For example, the first episode of "The King" makes the ancients in "The Emperor Accumulates Victory" walk, and with passionate music and simulated street noise, it shows the bustling street scene in history. This artistic treatment obviously touched the audience, and some netizens pointed out the details of men wearing pink clothes in the picture scroll in the barrage, indicating that the expression of the dynamic picture scroll aroused the audience’s interest and concern about the living customs of the Ming Dynasty. As Wu Zhiyong, the general director of the film, said, "Cultural relics are evidence, not for display". The previous documentaries on the theme of the Forbidden City mentioned cultural relics, which seemed to show the manufacturing process or artistic value of cultural relics themselves, rather than introducing related historical stories. For example, the seventh episode of the Forbidden City, Painting and Calligraphy in the Forbidden City, introduces the creation and preservation of paintings and calligraphy.Instead of focusing on the objective world revealed by the contents of calligraphy and painting. It can be seen that the Forbidden City shows the Chinese civilization more vividly and strengthens the audience’s perceptual knowledge of the Chinese nation through the historical information carried by cultural relics.

In recent years, the number of documentaries on the theme of the Forbidden City is quite large, which can be roughly divided into three categories: grand theme category, micro theme category and specific characters category. Among them, The Forbidden City (2005) is narrated based on several grand themes, from the macro perspectives of architectural art, use function, collection of cultural relics and the evolution process from the palace to the museum, showing all aspects of palace architecture, precious cultural relics, fate of characters and palace life, and emphasizing the value of the Forbidden City as a common historical and cultural heritage of mankind. Since then, When the Louvre meets the Forbidden City (2010) and The Forbidden City 100 (2012) have been narrated around micro-themes: the former deduces the art history of the East and the West in different time and space backgrounds, and emphasizes the valuable value of the exchange between Chinese and Western civilizations; The latter, based on the practical value of the Forbidden City building, expresses the aesthetic value and cultural connotation of the palace building with creative commentary and images in the form of micro-documentary. I am repairing cultural relics in the Forbidden City (2016), New Things in the Forbidden City (2017) and I am in the Forbidden City for 600 years (2020) record the daily work of cultural relics workers in the Forbidden City. They all focus on the stories of cultural relics protectors, which not only show the spirit of craftsmen, but also show the understanding of cultural relics by cultural relics restorers-the spirit of utensils that carry the Tao with things.

Looking at the documentaries on the theme of the Forbidden City since this century, we can find that its development vein presents the following two important characteristics, that is, not only its vision has undergone a "macro-micro-macro" evolution, but its expression mode is getting younger and younger. Among them, the change of vision is from the broad perspective at the beginning, to the interpretation of specific aesthetic values and cultural connotations, to the personal perspective of cultural relics protectors, and finally, to the grand perspective of the Chinese nation. The trend of younger expression is particularly obvious in the Forbidden City 100, I am repairing cultural relics in the Forbidden City and the Forbidden City. "Forbidden City 100" is a micro-documentary with a single episode of no more than six minutes, which meets the viewing needs of young people in a fast-paced society; The dedicated spirit of the elderly restorer and the youthful vitality of his disciples in "I am repairing cultural relics in the Forbidden City" have aroused the resonance of many young audiences; The theme song at the end of the Forbidden City has greatly expanded the audience by virtue of the singer’s social influence and the genre with both ancient meaning and popular elements.

The emergence of these two characteristics is related to the change of social environment. First of all, the rapid development of social economy has given birth to multiple values and the evolution of "macro-micro" vision. At present, the rapid development of world economy and technology requires us to re-examine and establish the spirit and identity of the Chinese nation, which has given birth to the transformation of "micro-macro" vision. Secondly, the ever-changing consumer society has also widened the differences in viewing habits between young people and middle-aged and elderly people. Documentary creators need to attract young audiences with younger expressions to further realize the social value of documentaries.

Looking back on the development of documentaries on the theme of the Forbidden City, we can see that people’s understanding of Chinese civilization is also deepening: from the overall grand impression to the specific artistic value, aesthetic value and cultural concept, to the craftsman spirit and utensils spirit of cultural relics protectors, to the survival wisdom of the Chinese nation shown in The Forbidden City. This cognitive process also reflects the mental outlook and value orientation of the Chinese nation in different historical stages. For example, "Forbidden City" no longer only shows the interior of the Chinese nation, but focuses on the history of the Chinese nation in a global perspective, and lets the audience see the vicissitudes and splendor of Chinese culture with the help of younger expressions.

Specially published by Shanghai Literature and Art Review Special Fund

Source: Jiefang Daily

Wen | Yao Lan

Clean Beauty is becoming a new fashion trend.

NPD, a well-known American market research organization, announced the impact of the COVID-19 epidemic on the beauty industry. The data showed that the sales of beauty products dropped by 14%, but the sales of pure beauty products rose by 11% against the trend. According to Tmall data, during the period of June 18 this year, the sub-categories such as essence, mask, cleansing and makeup remover under Tmall International Pure Beauty category all increased by more than 100% year-on-year.

What is "pure beauty"? In August this year, Tmall International Beauty and COSMOHits, the beauty media, made a clear definition of the concept of "pure beauty" for the first time, including four aspects: harmless addition of ingredients, environmental friendliness and zero harm, animal friendliness and cruelty, and sustainable environmental protection and zero waste.

Since 2020, foreign big beauty groups have invested in adding more pure beauty tracks (for example, Shiseido Group acquired Drunk Elephant, a brand of pure beauty and skin care, for US$ 845 million, and Unilever acquired Tatcha for US$ 500 million), and domestic pure beauty brands also came into being.

36Kr recently came into contact with China pure beauty brand "Dewy Lab Yiyi", which was founded in 2020, aimed at the core consumer groups such as sensitive muscles, pregnant women, medical beauty crowd and new white-collar workers, focusing on cosmetic products with both "pure ingredients" and "excellent makeup effect" and advocating a romantic feeling of "self-satisfaction". It is understood that "Dewy Lab" won the "Blogger’s Choice" Award in Little Red Book 2021WILL Future Brand Award.

The picture is provided by the enterprise.

Dewy Lab launched its first new product "Morning" series in January this year, including three single products: morning dew foundation cream, morning mist powder and morning glow blush cream. After launching the brand Tmall flagship store and the official applet, the monthly sales of single products have exceeded 10,000 at present.

Amber, the founder of Dewy Lab, told 36Kr that most cosmetic formulations on the market now are mainly designed with the basic goal of "beauty", focusing on makeup effect and skin feeling, regardless of whether the ingredients are harmful to the skin. "Dewy Lab Love" started from the first series, and its products focused on makeup, trying to give consumers peace of mind protection from the part closest to the skin.

The picture is provided by the enterprise.

The standard of pure make-up advocated by "Dewy Lab" includes three aspects:

First,user friendlyThat is, it does not contain harmful and controversial chemical components such as talcum powder, plastic beads, mineral oil, nipagin ester, etc. In order to provide unique pure beauty products, the brand will not only bring the research and discovery of raw materials and formulas by Chinese scientists in universities such as Cambridge University and University of Pennsylvania back to China, so as to speed up the product iteration, but also become a strategic partner with China Inspection Department to strictly control the formula of each product.

Second,Friendly life, that is, no animal experiments, and pet-friendly, playing licking is non-toxic. At this point, "Dewy Lab" hopes to help the development of front-end toxicology testing in the future.

Third,Environment friendlyAdvocate the recyclability and degradability of product packaging materials, take carbon neutrality as the ultimate goal, and constantly optimize production methods.

It is reported that the core team of Dewy Lab is from Cambridge University, University of Pennsylvania and Nanyang Technological University, and their main research directions are pharmacology, biochemistry and chemistry, which are closely related to the makeup formula and raw materials. On the basis of referring to the European and American brand purity standards, according to the front-end research results and credible academic journals, they have formulated and constantly updated the scientific, rigorous and systematic "Dewy Lab" brand purity standards.

At present, the brand has explored the triangular structure of product research and development: 1) the team of brand scientists strictly controls the use of raw materials to ensure the safety of ingredients; 2) Joint research and development with the formula laboratory to jointly break through the bottleneck of pure formula and ensure the exclusive use of formula; 3) Each product must be tried by top makeup artists in the industry to ensure excellent makeup effect and skin feel.

Amber said that at this stage, "Dewy Lab Love" mainly relies on social media to strengthen the spread of brand value proposition. In the future, we will continue to focus on the research and development of new products, bringing consumers more product choices and a more pleasant experience.

First, education is to squat down and talk to children. Education is to turn yourself into a child and turn the child into yourself.

In the journey of education, we often ignore an important detail, that is, the importance of equal dialogue with children. Squatting down to talk to children means that we should put down our posture and communicate with them in an equal manner. Only in this way can we truly understand their inner world and establish a close and trusting relationship.

Second, education is to listen to children’s voices.

Listening is an art and a kind of respect. In education, we should give children ample space to express themselves, listen to their voices and pay attention to their needs and ideas. Only by listening can we better understand children’s puzzles and problems and give them correct guidance and support.

Third, education is to let children become protagonists.

Every child is a unique individual, and they have their own interests, dreams and specialties. In education, we should respect children’s personality and make them the protagonists of learning. By stimulating their learning interest and potential, we can help them find their own advantages and values, thus cultivating confident, independent and creative individuals.

Fourth, education is companionship, not companionship.

Companionship is the most precious gift in education. In the process of children’s growth, we need to give them enough time and attention to share their happiness and difficulties with them. However, companionship is not only physical companionship, but also spiritual companionship. We should feel the emotional needs of children with our heart, give them warmth and support, and let them feel our love and care.

Fifth, education is to give children enough time to "think".

Children’s imagination is infinite, and their thinking often exceeds our imagination. In education, we should give children enough time to think and explore freely. Children can cultivate innovative thinking and problem-solving ability through "thinking in a whimsical way", thus laying a solid foundation for future development.

Education is a great cause, which concerns the growth and future of every child. It is necessary to create a loving and caring learning environment for children, so that they can thrive on the road of growth. Let’s work together to pave a bright road for the children’s future!

On December 5th, tongji hospital Junshan Campus was officially opened, which indicated that Chegu in China had taken another important step in promoting the development of health care, and the residents of Junshan New Town had another "home-front" hospital. It is a great concern of the people to get medical treatment, and it is also an important embodiment of improving social security, and it is also an urgent requirement to comprehensively promote the construction of a healthy China. Taking the construction of a close medical community as a breakthrough, accelerating the expansion and balanced distribution of regional high-quality medical and health resources, continuously pushing down the center of gravity and sinking resources, building a high-quality and efficient medical and health service system, and creating a "15-minute medical circle" are important measures to open up the "last mile" of primary medical services and improve people’s sense of access and satisfaction.

Construct a medical and health service system linked up and down. With the rapid progress in the construction of medical and health service facilities in China, how to maximize the efficiency of medical resource allocation has become a new topic. It is necessary to take large public hospitals as the "leader" and the construction of "medical association" as the core, build a specialist alliance, realize the interstitial evaluation of laboratory rooms in the medical association, mutual recognition of results, and the teaching of experts’ clinical rounds, so as to improve the allocation and utilization efficiency of medical resources. Accelerate the integration of family doctor team services into various community grids, and gradually realize the medical treatment mode of "seeking family doctors for minor illnesses and referring seriously ill patients to higher-level hospitals", so that data can run more, patients can run less, and a "15-minute medical circle" can be created to provide integrated and continuous health services for the masses.

Promote high-quality medical resources to benefit the grassroots. Looking forward to better medical conditions is an important part of people’s yearning for a better life. It is necessary to accelerate the orderly expansion and balanced distribution of high-quality medical resources, continue to push down the center of gravity and sink resources, and continuously improve the fairness and accessibility of basic medical and health services. Improve the grading diagnosis and treatment system, take online, offline and telemedicine as the carrier, train and guide local medical staff to improve the level and efficiency of diagnosis and treatment, provide assistance and agency services for people in need, improve the ability of diagnosis and treatment at the grassroots level, improve the patient’s medical experience, and enhance the attractiveness of primary medical and health institutions to patients, so as to achieve the goal of leaving the diagnosis and treatment of minor diseases, chronic diseases and common diseases at the grassroots level and gradually realize the full coverage of primary health services.

Strengthen the training of medical and health personnel. The key to further improve the quality of primary health services lies in attracting and retaining talents. Report to the 20th CPC National Congress, the Communist Party of China, proposed to develop and strengthen the medical and health team, with the focus on rural areas and communities. It is necessary to strengthen the construction of grassroots medical and health teams and strengthen the training and equipment of grassroots medical and health personnel with general practitioners as the focus. Constantly improve the career development mechanism of medical and health personnel, improve the incentive mechanism, implement the corresponding social security benefits, improve the medical environment and conditions, so that more talents can stay and stay, change "blood transfusion" into "hematopoiesis", stimulate the vitality of primary medical and health institutions, and let residents enjoy quality and convenient health services at their doorstep.

Source: Jingchu. com (Hubei Daily)

Author: Ren Yang (Wuhan Economic Development Zone)

Editor: Wang Shuxian

From scientist to entrepreneur, Yu Kai is not the first person to "run away" in the field of artificial intelligence.

Despite the previous achievements in scientific research, joining in entrepreneurship means facing the reality of bone feeling.

In March 2015, Yu Kai said in an interview: "If a business can get the resources it deserves to do what it wants, then choose to start a business; If you join a big platform and have more resources to do one thing, then join a big platform. " Sure enough, three months after that, he left Baidu and founded Horizon.

From the initial "no one pays the bill" to October this year, Horizon successfully won the investment of 2.4 billion euros from Volkswagen, setting the largest single investment record for Volkswagen in the past 40 years, and establishing a joint venture company with audi ag’s software company. The transformation of Yu Kai’s identity can be described as unsuccessful.

Before becoming the founder of Horizon, Yu Kai’s label was the top international scholar in the field of machine learning and the main promoter of deep learning technology in China. His published papers were cited more than 20,000 times, and he won the silver award for the best paper in ICML-2013 International Machine Learning Conference. He himself also served as the domain chairman of ICML and NIPS, two major conferences of machine learning.

Yu Kai’s achievements in the academic field go far beyond this.

NEC Research Institute of the United States was once one of the major centers of international machine learning research. During his tenure, Yu Kai established a highly prestigious technology research and development team in Silicon Valley. This team is one of the earliest and most active teams in the field of deep learning in the world. A series of technologies led and developed by him have pushed image object recognition to a new level worldwide, and won many international famous awards.

After joining Baidu in 2012, the voice technology team, deep learning technology team and image technology team led by Yu Kai won the "Baidu’s highest award" three times in succession, creating records of various technical and business teams within Baidu.

In the eyes of outsiders, Yu Kai at that time, both academically and professionally, was smooth sailing.

But at this time, he chose to start a business.

Yu Kai’s reason is straightforward: "In the past three years, what I have done at Baidu is to promote artificial intelligence in the cloud. But I think there will be a bigger trend in the next few years that I have to do: from artificial intelligence in the cloud to artificial intelligence around everyone. "

Therefore, Yu Kai, who has always believed in "doing things is the most important thing", founded Beijing Horizon Information Technology Co., Ltd. in July 2015, focusing on edge computing in the field of artificial intelligence.

From the moment the company was founded, in his own words: First of all, I will forget that I am a scientist more and more.

To be a scientist, you can put the mainexperienceDo research and write papers, but as an entrepreneur, you should focus more on business and customer needs.

Yu Kai has always wanted to grasp some "truth" things in this process, for example, things that can really create long-term value. With this idea in mind, at the beginning of Horizon’s establishment, he played the slogan of "making brains for machines", and avoided the edge of the field giants, took the edge computing route, and insisted on making AI chips.

It was really hard at first.

When recalling the initial stage of starting a business and determining the development direction, Yu Kai mentioned: At that time, we were predicting a far future, a future that might take 20 years as its dimension. From computers to smart phones, and beyond, what is a bigger computing platform than these? At that time, they were sure,beRobot computing platform. AI chip is the indispensable key to realize this calculation.

Now that we hear about AI chips, it’s needless to say its importance. But when Horizon was founded, not every investor could understand the "blueprint" in Yu Kai’s eyes. As a direct result, the horizon was once unsustainable. Until smart cars become "robots"calculate"The first and biggest landing scene at present, everyone began to understand that Yu Kai had bet on it.

In 2020, smart cars ushered in an outbreak period. As a result, there is a global "lack of core" in the automotive industry.question.

A chip with excellent computing power, like a smart brain, can accurately control the behavior of the vehicle. A series of functions, such as environmental awareness, route planning, driving assistance and so on, advertised by smart cars all need to rely on chips to be realized.

This is also consistent with what Yu Kai has always wanted to do. He has always believed that the real significance of artificial intelligence is not to survive and develop as the opposite of human life, but to support people’s decision-making and enhance their ability. Once the smart car scene is broken down, this ability will definitely spill over to others.floatApplication scenario of robot.

In August 2019, Horizon announced the mass production of China’s first car-class AI chip "Journey 2";

In September 2020, Horizon officially launched the AI chip "Journey 3";

In July, 2021, Horizon released "Journey 5", a high-performance and large-computing, full-scene intelligent central computing chip for the whole vehicle.

……

Yu Kai once said, "The course of a scientist’s entrepreneurship is not based on business opportunities,FromStart in the future. "

This cooperation between Horizon and Volkswagen may be the next future in Yu Kai’s plan.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

Ding Yan Yuhang, a Shandong player who hasn’t updated his personal social dynamics for a long time, recently updated his personal social media. He took a big photo of the China men’s basketball team participating in this World Cup qualifier, and gave his best wishes to his friends. Originally, this was a perfectly normal dynamic, but some fans thought that Ding Yanyuhang was rubbing against the popularity of China men’s basketball team. In fact, it was a bit unfair to Ding Yanyuhang. After all, Xiaoding’s wishes for the national team and friends were sincere, and fans should not be mixed with too much personal feelings.

For Ding Yan Yuhang, some fans also very much hope that he can return to the national team. It is also a great encouragement for Ding Yan Yuhang to see that Abdul Salamu, who has suffered serious injuries like him, has already returned to the national team. Du Feng has also given all players a chance. After all, it is the greatest honor for a player to play for the national team, and it is also a very confidence-boosting thing to have the opportunity to enter the national team after a serious injury.

Recently, there are a lot of news about China men’s basketball team, one of which makes the fans very worried. That is, when qi zhou participated in nbl preseason, many of their opponents were found to have COVID-19. qi zhou, as a close contact, is likely to be isolated and missed. However, recently, some media broke the news that qi zhou appeared in China men’s basketball team’s training abroad, which broke the previous rumor that qi zhou would miss the preliminaries. China men’s basketball team has been sent to the strongest team in the world, hoping that they can break into the final with all their might.

The second phase of the cba is about to start, and wcba has already gone through six rounds. Compared with the attention of CBA in China, there are few fans in wcba. Up to now, three teams in WCBA have maintained an unbeaten record this season, namely the defending champion Inner Mongolia team, Sichuan team and Shandong team. In the first six rounds, Inner Mongolia team beat their opponents by a big score, and their biggest competitor this season is Sichuan team, which is temporarily ranked third.

In fact, after seeing the lineups of the two teams, the fans were not surprised why the two teams competed for the championship. Together, the two teams gathered a total of 17 national players. The Inner Mongolia team gathered 9 national players including Li Yueru, Yang Liwei, Huang Sijing, Zhao Shuang, Zhang Ru, Pan Zhenqi, Ma Xueya, Wei Wei and Li Yifan, while the Sichuan team had Han Xu, Wu Di, Shao Ting, Li Meng, Sun Mengran, Li Shanshan and so on.

In today’s cba league, Guangdong men’s basketball team and Liaoning men’s basketball team are still the two strongest teams. Compared with the 11th championship of Guangdong men’s basketball team, Liaoning men’s basketball team has won the championship of cba league only once, but the runner-up has won many times, which has also been criticized by many fans. Liaoning fans who are very unconvinced listed the past record of Liaoning team, and the time goes back to the national basketball championship in 1985. As we all know, cba league only has a history of more than twenty years. Here

According to the statistics of the fans, since 1985, Liaoning men’s basketball team has won 12 championships in many competitions, such as the National Basketball Championship, the National Basketball League, the National North-South Championship, the National Games, the Asian Club Cup, cba, Extraordinary 12, etc. From this figure, it has indeed surpassed Guangdong’s 11 championships. In fact, just from the data point of view, it can’t explain too many problems. After all, the glory created by our predecessors has become.