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Beijing Zhengban Fa [2018] No.37

District People’s governments, municipal government commissions, offices and bureaus, and municipal institutions:

　　With the consent of the municipal government, the Beijing Action Plan for Accelerating Collaborative Innovation of Medical Health (2018-2020) is hereby printed and distributed to you, please conscientiously implement it according to the actual situation.

General Office of Beijing Municipal People’s Government

September 27, 2018

Beijing Action Plan for Accelerating Collaborative Innovation of Medical Health (2018-2020)

　　This action plan is formulated in order to thoroughly implement the State Council’s decision-making and deployment on promoting the healthy development of the pharmaceutical industry, conscientiously implement the Guiding Opinions of Beijing Municipality on Accelerating the Development of the Pharmaceutical and Health Industry through Scientific and Technological Innovation, further promote the high-quality development of the pharmaceutical and health industry in this city, and accelerate the construction of the collaborative innovation system of Industry-University-Research.

　　I. General requirements

　　(A) the guiding ideology

　　Comprehensively and thoroughly study and implement the spirit of the 19th National Congress of the Communist Party of China, take Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era as the guide, conscientiously implement the spirit of the important speech delivered by the General Secretary of the Supreme Leader to Beijing, adhere to the new development concept, give full play to the advantages of science and technology and talents in the capital, follow the law of scientific and technological innovation and industrial development in medicine and health, aim at bottlenecks and common needs, and focus on key areas such as frontier technologies in life sciences, emerging industries where doctors and workers cross, and sophisticated pharmaceutical industries. Efforts will be made to deepen the reform of institutional mechanisms, gather innovative elements, strengthen collaborative innovation, optimize the business environment, and continuously improve the level of medical health innovation and development, providing strong support for building a national science and technology innovation center, building a sophisticated economic structure, and promoting high-quality development.

　　(2) Basic principles

　　Adhere to the problem orientation. Grasp the key links such as basic research, transformation of achievements and industrialization, deeply analyze the key and difficult problems faced by medical health innovation and development, make precise efforts, make comprehensive policies, fill shortcomings, strive to break down institutional and institutional obstacles, and effectively solve the "stuck neck" problem that restricts development.

　　Pay attention to original innovation. Grasp the frontier development trend of life science and biotechnology, focus on the research and development of innovative drugs and high-end medical devices, take universities and research institutes as the source of innovation, increase the intensity of basic research, strengthen the output of original achievements, and enhance the ability of independent innovation.

　　Strengthen collaborative transformation. Give full play to the advantages of innovative resources, especially medical innovative resources, and carry out collaborative research with major clinical application needs as the traction; Actively guide medical institutions to strengthen cooperation with enterprises, smooth the channels for the transformation of scientific research achievements of medical institutions, realize the collaborative innovation of Industry-University-Research medical institutions, and effectively promote the transformation of achievements.

　　Promote high-end development. Accelerate industrial transformation and upgrading, vigorously promote the integration of medical health with artificial intelligence and big data technology, actively cultivate emerging formats, and provide new kinetic energy for industrial development; Intensify efforts to guide the gathering of various international innovation factors, actively promote the extension of industrial value chain to the high end, and optimize the construction of high-end industrial system.

　　(3) Development goals

　　By 2020, we will introduce and cultivate a number of world-class innovation teams and a number of key enterprises with strong independent innovation capabilities, and the original innovation capabilities will continue to lead the country; The professional incubation ability has been significantly improved, and the transformation system of scientific and technological achievements has become more sound; The innovation system and mechanism of medical institutions have been further improved, the level of clinical research has been greatly improved, and the spillover effect of medical resources has been significantly enhanced; The industrial policy has been further refined, the industrial elements have been further concentrated, the industrial environment has been further optimized, and the Industry-University-Research medical collaborative innovation system has taken shape; The scale of the industry has further expanded, with an additional development space of about 10 square kilometers, and the main business income has reached 250 billion yuan.

　　Second, the key tasks

　　(A) to strengthen basic research and achievements transformation, enhance innovation ability.

　　1. Increase support in key areas. In some frontier areas, new R&D institutions will be built, and at the same time, a number of scientific apparatus will be laid out to support the cultivation of original innovation achievements and accelerate the breakthrough of frontier technologies. Formulate a catalogue of key directions for collaborative innovation and development of medical health in Beijing, focus on supporting basic research such as stem cells and regenerative medicine, brain science and brain-like medicine, structural biology, synthetic biology and protein omics, promote the development of technologies such as immunotherapy, gene detection and new sequencing, multimodal and cross-scale biomedical imaging, and promote the development of innovative drugs, high-end medical devices, and the integration of medical health with artificial intelligence and big data technology. (Responsible unit: Municipal Science and Technology Commission, Municipal Health and Family Planning Commission)

　　2. Strengthen the professional incubation capacity building. Improve the incubation capacity of professional incubators in Beijing Economic and Technological Development Zone, Haidian District and Daxing District, and strengthen comprehensive services such as evaluation and consultation, intellectual property rights, law and finance. Pilot the construction of professional incubators in Zhongguancun Life Science Park and other parks, and select international operation management institutions; Actively promote the pilot experience and build a number of professional incubators in the concentrated areas of colleges and universities, research institutes and medical institutions. (Responsible units: Municipal Science and Technology Commission, Zhongguancun Management Committee, Municipal Education Commission, Beijing Economic and Technological Development Zone Management Committee and relevant district governments)

　　3. Accelerate the upgrading and construction of Zhongguancun Life Science Park. Establish the strategic steering committee of Zhongguancun Life Science Park, and improve the management structure and working mechanism of the park. Optimize and upgrade the service functions of Zhongguancun Life Science Park in the first and second phases, and start the planning and construction of the third phase. Introduce international park management service team, third-party R&D and production service enterprises, professional intermediaries, social capital and other supporting elements, actively create a world-class innovation and development environment in line with international standards, and strive to make Zhongguancun Life Science Park a professional park with global influence, providing strong support for strengthening original innovation in the field of medicine and health. (Responsible units: Zhongguancun Management Committee, Municipal Science and Technology Commission, Haidian District Government, Changping District Government, Zhongguancun Development Group)

　　(B) improve the level of clinical research, play a spillover effect.

　　4. Improve the level of clinical research and experiment. Further speed up the layout of the national and Beijing clinical medical research centers and give full play to their leading role in clinical research. Adopt the co-construction mode of medical institutions, universities, scientific research institutes and enterprises, introduce an international operation management team, pilot the construction of independent clinical trial hospitals, and actively explore the sustainable operation mechanism. Support tertiary medical institutions to set up research wards to carry out high-level clinical medical research; On the basis of the existing drug clinical trial institutions, explore the establishment of clinical trial collaborative network in various ways to solve the problem of insufficient resources such as clinical trial beds in tertiary medical institutions and effectively support the needs of clinical trials. (Responsible units: Municipal Health and Family Planning Commission, Municipal Science and Technology Commission, Municipal Finance Bureau, Municipal Food and Drug Administration, Municipal Hospital Administration, Zhongguancun Administrative Committee, Beijing Economic and Technological Development Zone Administrative Committee, Changping District Government, Haidian District Government)

　　5. Optimize the system and mechanism of scientific and technological innovation in medical institutions. Promote the transformation of clinical trials and results as an important basis for the performance evaluation of medical institutions and the evaluation of personnel titles. We will adjust and improve the post setting of medical institutions, the pricing of scientific and technological achievements, the distribution of income disposal, and the exemption of key management personnel from due diligence, and issue detailed rules for the implementation of medical institutions to encourage scientific and technological innovation and the transfer and transformation of achievements. Improve the construction standards of scientific research houses in medical institutions, and ensure the scientific research land of medical institutions undertaking clinical trials. (Responsible units: Municipal Health and Family Planning Commission, Municipal Development and Reform Commission, Municipal Planning and Land Commission, Municipal Finance Bureau, Municipal Hospital Administration, Municipal Human Resources and Social Security Bureau, Beijing Economic and Technological Development Zone Administrative Committee and relevant district governments)

　　6. Guide medical institutions to accelerate the transformation of results. Strengthen the collaboration between medical institutions and enterprises, and explore the establishment of a collaborative innovation research institute for medical health to promote the transformation of scientific and technological achievements. Explore the establishment of medical health innovation and transformation funds by medical institutions, joint ventures, social capital, industrial technology alliances, etc., to support medical science and technology innovation and transformation of achievements. (Responsible units: Municipal Health and Family Planning Commission, Municipal Hospital Administration, Municipal Science and Technology Commission, Municipal Finance Bureau)

　　7. Promote the co-construction and sharing of medical and health data. On the basis of the clinical data and sample database of major diseases in Beijing, we will build a unified, open and shared biological sample database, a health big data center and a digital clinical research network in the city to promote the standardization of clinical medical data and the open interoperability of inter-hospital data. (Responsible units: Municipal Health and Family Planning Commission, Municipal Hospital Administration, Municipal Science and Technology Commission, Municipal Economic Information Commission)

　　(C) focus on cultivating key enterprises to enhance core competitiveness

　　8. Strengthen the overall service of key enterprises. Strengthen the follow-up service for key enterprises, keep abreast of the development trends and needs of enterprises, strengthen departmental linkage and policy integration, and solve the problems encountered by enterprises in the process of R&D, production and operation in a timely manner by means of "one enterprise, one policy, one thing and one discussion". (Responsible units: Municipal Science and Technology Commission, Municipal Economic Information Commission, Municipal Health and Family Planning Commission, Zhongguancun Management Committee, Beijing Economic and Technological Development Zone Management Committee, Municipal Food and Drug Administration, Municipal Human Resources and Social Security Bureau, Municipal Finance Bureau)

　　9. Promote the innovation and development of R&D enterprises. Study and establish a green channel for the approval of innovative varieties, and coordinate and accelerate clinical trials; After the varieties are mature, we will support R&D enterprises to develop into production-research integration enterprises, build high-end product production lines, and promote the transformation and large-scale production in Beijing. (Responsible units: Municipal Science and Technology Commission, Municipal Economic Information Commission, Municipal Food and Drug Administration, Beijing Economic and Technological Development Zone Administrative Committee, and relevant district governments)

　　10. Support production enterprises to become stronger and bigger. In terms of production line upgrading, scale expansion of listed varieties, secondary development of key varieties, international market expansion, listing financing and mergers and acquisitions, we will increase support to promote enterprises to continuously enhance their core competitiveness. (Responsible units: Municipal Economic Information Commission, Municipal Science and Technology Commission, Municipal Finance Bureau, Zhongguancun Management Committee)

　　11. Strengthen third-party R&D and production services. Introduce high-end service-oriented institutions or teams at home and abroad, and encourage the construction of third-party R&D service platforms and OEM service platforms that meet international standards; Strengthen policy guidance, provide support for international certification of platform technical standards and quality specifications, and ensure supporting conditions such as capital, land and factory buildings. (Responsible units: Municipal Economic Information Commission, Municipal Science and Technology Commission, Zhongguancun Management Committee, Municipal Finance Bureau and Municipal Environmental Protection Bureau)

　　12. Accelerate the establishment of production and professional service platforms. In Haidian District and Changping District, a thousand-liter pilot service platform for biopharmaceuticals will be built to meet the demand for commissioned production of scientific research samples and clinical trials of innovative subjects. In Beijing Economic and Technological Development Zone, relying on professional service enterprises with strong existing technical strength and complete software and hardware conditions, we will build a 100,000-liter biopharmaceutical OEM production service platform to realize the large-scale production of antibody drugs and cell therapy drugs. (Responsible units: Municipal Science and Technology Commission, Municipal Economic Information Commission, Zhongguancun Management Committee, Municipal Environmental Protection Bureau, Beijing Economic and Technological Development Zone Management Committee and relevant district governments)

　　13. Support the development of multinational companies in Beijing. Make full use of the international cooperation channels of universities and research institutes, actively connect with the world’s top medical and health multinational companies, and support them to build their headquarters and R&D centers in Beijing. Focusing on the strategic adjustment of R&D centers of multinational companies, we will do a good job in docking services and adopt various cooperation modes to promote talent teams and key projects to land in Beijing. (Responsible units: Municipal Science and Technology Commission, Zhongguancun Management Committee, Municipal Economic Information Commission)

　　14 to promote the innovation and development of Chinese medicine industry. Relying on the institutions of higher learning and scientific research institutes in the field of traditional Chinese medicine in this city, we will promote the integration of traditional Chinese medicine theory and modern science, strengthen the construction of modern technology platforms such as the design and optimization of traditional Chinese medicine and the system control of pharmaceutical process, and further increase the research and development and transformation of classic prescriptions of traditional Chinese medicine and in-hospital preparations. Give play to the leading role of leading enterprises in innovation, strengthen the research and development of new Chinese medicine and the secondary development of large varieties of Chinese medicine. Support Chinese medicine enterprises to use standardized, automated and intelligent technologies to transform and upgrade traditional processes, and give full play to the preventive and therapeutic effects of Chinese medicine on major chronic diseases, difficult diseases and senile diseases. (Responsible units: Municipal Administration of Traditional Chinese Medicine, Municipal Science and Technology Commission, Municipal Economic Information Commission)

　　(D) Improve industrial development factors and optimize the business environment.

　　15. Promote the development of industrial agglomeration. The relevant areas that list the medical and health industry as the leading industry should make strategic plans for industrial development as soon as possible, make clear the new space and speed up the industrial layout. The northern part (Haidian District and Changping District) should give full play to the scientific research advantages of Zhongguancun Science City in basic research and cutting-edge technology of medicine and health, and form a strong support for industrial development; In the southern part (Beijing Economic and Technological Development Zone and Daxing District), in the planning and utilization of land space, we should strengthen the guarantee for the development of medical and health industry, guide the centralized layout of enterprises and projects, and further enhance the advantages of high-end manufacturing agglomeration. (Responsible units: Municipal Economic Information Commission, Municipal Development and Reform Commission, Municipal Planning and Land Commission, Zhongguancun Management Committee, Municipal Environmental Protection Bureau, Beijing Economic and Technological Development Zone Management Committee, relevant district governments and Zhongguancun Development Group)

　　16. Optimize the service system of the park. Strengthen the evaluation of medical and health professional parks, further clarify the functional orientation of parks, and strengthen the planning and service system construction of parks. R&D parks should strengthen the construction of soft environment, build investment and financing platforms, one-stop comprehensive service platforms and international exchange and cooperation platforms, and create an open and shared academic environment; Manufacturing parks should rationally arrange industrial space, speed up "changing cages for birds", build a service platform for OEM production, and strengthen the professional service capacity building of parks. Actively hold industrial forums and academic activities with international influence to build a platform for investors, scientists and entrepreneurs to communicate. Further improve the service level of the "one-stop" public service platform for entry and exit inspection and quarantine of special articles and biological materials of animal and plant origin in Zhongguancun Life Science Park and the "biochemical reagent Centralized Supervision Platform for Entry and Exit" of Zhongguancun International biochemical reagent Logistics Center in Beijing Economic and Technological Development Zone, and improve customs clearance efficiency. (Responsible units: Zhongguancun Management Committee, Municipal Economic Informatization Committee, Beijing Economic and Technological Development Zone Management Committee, relevant district governments and Zhongguancun Development Group)

　　17. Encourage the procurement and application of innovative products. Study and formulate evaluation and screening standards and identification procedures for innovative products of medical health, form a catalogue of new technologies and new products (services) in the field of medical health, and promote their inclusion in policy support systems such as government procurement and popularization and application. Municipal medical institutions set up a rapid evaluation and approval system for the procurement of innovative products on a pilot basis, and encourage the procurement of products in the catalogue of new technologies and new products (services) in the field of medicine and health. Conscientiously implement the Opinions of the General Office of the State Council on Improving the National Essential Drug System (Guo Ban Fa [2018] No.88), and actively promote the inclusion of innovative products and drugs that have passed the consistency evaluation in the national and municipal essential drug lists. (Responsible units: Municipal Science and Technology Commission, Municipal Health and Family Planning Commission, Municipal Food and Drug Administration, Zhongguancun Management Committee, Municipal Economic Information Commission, Municipal Finance Bureau, Municipal Hospital Administration, Municipal Human Resources and Social Security Bureau)

　　18. Optimize the price management methods of new medical services. Deepen the reform of medical service price, speed up the formulation of detailed rules for the implementation of price management of new medical service items in public medical institutions in this Municipality, explore the implementation of dynamic management, and speed up the evaluation of new diagnosis and treatment technologies and products with strong innovation and high clinical application value when approving new medical service charges. (Responsible unit: Municipal Health and Family Planning Commission, Municipal Development and Reform Commission)

　　19. Accelerate the implementation of the drug listing license holder system. According to the requirements of the State Council on the pilot system of drug marketing license holders, we will speed up the formulation of implementation plans from the aspects of review, approval, supervision and management, further encourage drug innovation and improve drug quality. (Responsible units: Municipal Food and Drug Administration, Zhongguancun Management Committee)

　　20. Increase innovation incentives. Relevant areas with the medical and health industry as the leading industry should study and introduce measures to give corresponding incentives to enterprises whose main business income reaches a certain scale for the first time, whose major innovative varieties are first approved for listing in China or approved for listing in European and American countries, and whose generic drugs pass the consistency evaluation. (Responsible units: Municipal Economic Information Commission, Zhongguancun Administrative Committee, Municipal Food and Drug Administration, Beijing Economic and Technological Development Zone Administrative Committee and relevant district governments)

　　Third, safeguard measures

　　(1) Strengthen overall coordination. Establish a joint meeting system, regularly consult and dispatch, coordinate and promote the collaborative innovation of medical health in this city, coordinate and solve key and difficult problems in industrial development in a timely manner, and ensure the effective implementation of the action plan. Set up an expert steering Committee to provide advice on the organization and implementation of the action plan.

　　(2) Pay close attention to the implementation of tasks. Relevant municipal departments and relevant district governments should conscientiously perform their duties, formulate supporting policies and measures and refine the implementation plan in light of the actual situation. The municipal government authorizes Beijing Economic and Technological Development Zone, Haidian District, Daxing District and Changping District to independently decide on individual projects with total government support of less than 1 billion yuan. Establish a dynamic assessment system, include the completion of the action plan in the assessment index system of relevant departments and districts, strengthen inspection and evaluation, and promote the implementation of the action plan.

　　(3) Strengthen talent support. Select top talents and teams with international influence, and provide continuous and stable support through the establishment of Beijing Medical Health Frontier Innovation Project. Give full play to the role of various talent training platforms, and strive to train a group of high-quality and high-level management talents with international vision. Strengthen the service of top talents and teams in the field of medicine and health, and do a good job in supporting medical care, education and housing.

　　(4) Do a good job in ensuring funds. Focus on innovative drugs, high-end medical devices, and original innovations in the fields of medical health, artificial intelligence, and big data technology, and increase financial investment at the urban level. Relying on Beijing Science and Technology Innovation Fund to set up sub-funds in the field of medicine and health, attract social capital to participate, and actively support innovative projects at different stages. Strengthen investment and financing services such as listing, mergers and acquisitions, and broaden financing channels for enterprises.

According to public information, Zhixiang Life Electric Appliance Manufacturing Co., Ltd. was established recently. The legal representative is Xu Pingping, with a registered capital of 10 million yuan. Its business scope includes: research and development of household appliances; Household appliances manufacturing; Sales of household appliances; Sales of spare parts for household appliances; Retail of household appliances; Repair of household appliances, etc. According to the equity data, the company is wholly owned by Guangdong Midea Environmental Electric Appliance Manufacturing Co., Ltd., a subsidiary of Midea Group.

Original pediatric doctor Yan, pediatric doctor Yan

Since the second half of 2023, Meituan and JD.COM Platform have carried out rapid home nucleic acid detection in some cities. At present, the testing items are as follows:

There are always parents who ask me: Is the quick test of nucleic acid at home accurate or not?

In fact, doctors and colleagues and I often discuss this issue. Our feeling is that sometimes it is accurate and sometimes it is not.

Through nearly half a year’s contact, we found that the rapid detection of nucleic acid at home is helpful to analyze the cause of upper respiratory tract infection in the community. In particular, the newly added pertussis test is convenient for early investigation and is really useful.

However, the detection rate of individual pathogens is doubtful, and some testing items seem unnecessary.

Here are two valuable cases. These two children not only did a quick home nucleic acid test, but also measured a very accurate tNGS (targeting high-throughput sequencing), which can be compared and analyzed.

As always, thank parents for their consent before sharing.

01

Case 1

A 7-year-old child saw a doctor at 12 noon on June 21st. The medical history is as follows:

When I saw a doctor, I had been coughing for 5 days. Because his deskmate was recently diagnosed with whooping cough, according to the clinical diagnosis standard B of CDC in the United States, if other diseases are excluded, whooping cough can be clinically diagnosed without laboratory tests.

Considering the 14-day course of antibiotic treatment and whether the family members take post-exposure prevention, after discussion with parents, it was decided that the presence of pertussis should be determined by rapid examination in JD.COM, and the drug-resistant pertussis infection should be evaluated by targeted sequencing. The specific plan is as follows:

At 15: 16 (more than 2 hours after sampling), the quick test results show that:

At noon on June 22nd (the second day after seeing a doctor), targeted sequencing showed that:

Through this case, we can draw the following conclusions:

1. The Bordetella pertussis detected this time is accurate (confirmed by sequencing).

2. The Streptococcus pneumoniae strain detected this time is false positive (negated by sequencing).

Why is there a false positive?

It is speculated that the primer design for rapid detection of Streptococcus pneumoniae in laboratory has defects and insufficient specificity, and Streptococcus angina with similar nucleic acid sequence is mistaken for Streptococcus pneumoniae.

3. The Haemophilus influenzae detected this time is accurate (confirmed by sequencing).

4. Targeted sequencing can identify whether there is drug resistance gene mutation in Bordetella pertussis, which is convenient for drug selection.

Reminder again: We must seize the opportunity to treat pertussis, because at present, drug-resistant pertussis is the main epidemic in China, so compound sulfamethoxazole is recommended as the first choice for empirical treatment.

▲ Guidelines for diagnosis, treatment and prevention of whooping cough in China (2024 edition)

02

Case 2

3 years and 7 months, I saw a doctor on July 13th (Day 2), and my medical history is as follows:

Initial diagnosis of acute laryngitis (mild). Because the symptoms suggest viral infection (especially parainfluenza virus), no pathogenic test was made at the first diagnosis.

The children returned home with high fever that day, and the parents made a quick inspection of the US delegation. The results are as follows:

You see, the US Mission has detected three kinds of "conditional pathogens" quickly, but there is no parainfluenza virus detection project, which makes parents feel strange.

In the next few days, the progress of this child’s illness is worrying.

On the 14th (Day 3), repeated high fever, the highest is 40.1℃.

On the 15th (Day 4), the highest temperature was 40.7℃. I went back to the clinic for targeted sequencing.

On the 16th (Day 5), sequencing showed that:

On the 16th (Day 5), the child developed yellow tears. His body temperature was 39.7℃ during the day and nearly 40.1℃ at 10 pm. My parents contacted me.

Combined with the sequencing results and the change of symptoms, I considered the virus combined with bacterial infection, and started amoxicillin and clavulanate potassium that night.

On the morning of the 17th (Day 6), the body temperature gradually dropped and pus increased. My temperature has been normal since the afternoon of the 17th.

Through this case, we can draw the following conclusions:

1. The Streptococcus pneumoniae strain detected this time is false positive (negated by sequencing).

2. The Pseudomonas aeruginosa detected this time is false positive (negated by sequencing).

3. The Haemophilus influenzae detected this time is accurate (confirmed by sequencing).

4. The parainfluenza virus detected by sequencing is the pathogenic pathogen that causes the initial symptoms of children, but the detection project has been cancelled by Meituan (which has been kept by JD.COM Quick Inspection so far).

5. The sequencing results are helpful for judging the virus combined with bacterial infection, and this result is also the basis for my difficult decision to start antibiotic treatment at 11 o’clock on the 16th.

03

Is home nucleic acid testing accurate or not?

Any new thing can’t be perfect, there will always be some problems that need to be constantly improved and improved.

Since it is an improvement, it should be improved as possible.

For example, it is very good to add pertussis and group A streptococcus detection items to the home quick inspection.

However, the US Mission cancelled the parainfluenza virus detection and increased the detection of Pseudomonas aeruginosa and Klebsiella pneumoniae with low value, which is puzzling.

Pathogen detection is very important for the management of some infectious diseases, so we should have higher requirements, which is not too much.

If the test results are inaccurate, some pathogens will always be false positive, which will not only lead to patients’ (or their families’) worries, but also lead to wrong intervention, increase the doctor’s interpretation cost and waste the doctor’s time.

The two cases I cited earlier are just cases, which are not convincing enough. Whether home nucleic acid is accurate or not depends on a large sample survey.

We can collect enough home nucleic acid and targeted sequencing results, and then analyze the difference of pathogen positive rate; If a patient has done home nucleic acid and targeted sequencing at the same time, the control analysis is more valuable.

Ben WeChat official account plans to write a series of articles to discuss how to manage common upper respiratory tract infectious diseases by home quick check-up.

Here, I especially hope that the testing organization will make this product better. For example, quality control personnel should carefully analyze the test data, find out the reasons for the high detection rate of pathogens such as Streptococcus pneumoniae, resume the detection of parainfluenza virus, and cancel some unnecessary tests.

In order to make a more rigorous evaluation, we collect home nucleic acid test results from readers, and the requirements are as follows:

1. Provide a complete test report screenshot. If there are other pathogen detection reports (such as targeted sequencing or antibody detection results), they can also be provided together. Please cover the patient’s name.

2. Sampling sites (such as throat swab and nasopharyngeal swab) can be provided.

3. Can inform the patient’s age, main symptoms (such as fever, cough, runny nose) and city.

https://www.wenjuan.com/s/uuqEBnn/

Thanks for your support.

　

The pediatrician slides up to see the next one.

Original title: "Quick test of nucleic acid at home, is it accurate or not? 》

Read the original text

　　■ In June, a total of 34.767 billion yuan of lottery tickets were sold nationwide, a decrease of 23.862 billion yuan or 40.7% over the same period of last year.

　　■ Not only did the monthly data decline, but the reporter combed the lottery sales data in the first half of the past decade and found that the lottery sales showed negative growth year-on-year for the first time in the first half of this year.

　　■ What causes the lottery market to be cold? What is the future trend of lottery market? The reporter combed and interviewed this.

　　Encounter cold

　　In the first half of the year, national lottery sales fell first.

　　Lottery sales were cold this year. From January to June, the national lottery sales totaled 212.596 billion yuan, a year-on-year decrease of 32.602 billion yuan or 13.3%. Among them, the sales of welfare lottery institutions was 97.757 billion yuan, a year-on-year decrease of 12.838 billion yuan or 11.6%; The sales of sports lottery institutions reached 114.839 billion yuan, a year-on-year decrease of 19.764 billion yuan or 14.7%.

　　The reporter combed 2010 — The lottery sales data in the first half of the decade in 2019 found that this was the first time that there was a year-on-year decline.

　　Judging from the monthly data, in June this year, the country sold a total of 34.767 billion yuan of lottery tickets, down 40.7% from the same period of last year. The year-on-year decline was mainly due to the large sales of quiz lottery games in the World Cup in June 2018, with a high base in the same period last year. In the first half of 2018, lottery sales increased by as much as 19.6%.

　　Looking back on the lottery market in the past ten years, from 2010 to 2012, it experienced a double-digit rapid growth period, and then the growth rate gradually decreased to single digits, and negative growth occurred for the first time in the first half of 2019.

　　The data shows that from 2010 to the first half of 2012, the national lottery sales maintained a rapid growth of more than 20%, which was a period of rapid growth of China’s lottery market; In 2013 and 2014, the growth rate of national lottery sales fell below 20%; From 2015 to the first half of 2017, the growth rate of national lottery sales dropped significantly, only 5.2%, 3.5% and 5.5% respectively.

　　Where do people prefer to buy lottery tickets when lottery sales are relatively low? Geographically, data from the Ministry of Finance show that in June, compared with the same period of last year, lottery sales in 31 provinces all declined. However, from the cumulative data in the first half of the year, compared with the same period of last year, lottery sales in five provinces increased, namely Sichuan, Shanghai, Henan, Anhui and Beijing, with year-on-year increases of 1.681 billion yuan, 234 million yuan, 190 million yuan, 172 million yuan and 45 million yuan respectively. As far as the overall sales volume in the first half of the year is concerned, Guangdong, Jiangsu, Shandong, Zhejiang and Henan rank among the top five in the country.

　　cause

　　Strengthen the supervision of high-frequency fast-opening games

　　Why did lottery sales decline in the first half of this year? An expert in the lottery industry told reporters that at the beginning of this year, in order to regulate the lottery market, the Ministry of Finance, the Ministry of Civil Affairs and other departments strengthened the supervision of high-frequency quick-opening games and quiz games, extended the sales time of high-frequency quick-opening games and reduced the number of lottery games.

　　High-frequency fast-opening games mainly complete the process from sales to lottery every few minutes or ten minutes through electronic equipment.

　　The data shows that in 2017, the share of Fucai quick-opening games in the total sales of Fucai reached 40%. In that year, the total sales volume of national welfare lottery was 216.977 billion yuan, of which the sales of quick-opening games was 87.522 billion yuan.

　　A lottery player told reporters: "The number of high-frequency fast-opening games is small, there are many awards, and the lottery is frequent. Many domestic lottery buyers are speculative when buying high-frequency fast-opening games, and some lottery buyers can play all day and easily lose their minds."

　　The reporter noted that in January this year, the Ministry of Finance, the Ministry of Civil Affairs, and the General Administration of Sports issued a notice to adjust the rules of high-frequency fast-opening lottery games and quiz lottery games, and strengthen the supervision of the lottery market. According to the notice, in recent years, China’s lottery industry has generally shown a sustained and healthy development trend. At the same time, there are still irrational lottery buying phenomena in the lottery market, such as unauthorized use of the Internet to sell lottery tickets and large bets. In particular, the market supervision of welfare lottery quick-opening games, sports lottery high-frequency games and sports lottery national online single-game quiz games needs to be strengthened. The notice is clear. From February 11th, if the sales time of high-frequency quick-start games is shorter than 20 minutes, it will be adjusted to 20 minutes.

　　Since 2019, the number of contests and events for the annual quiz game shall not be higher than 70% of the number of contests and events for sale in 2018. The aforementioned experts also pointed out to reporters that the main reason is that there was a World Cup in June 2018. At that time, the sales volume of lottery was particularly large, and the sales volume of sports lottery was also particularly large. However, there were no important sports events in June this year. The sharp decline in sports lottery sales in June was an important factor in the decline in lottery sales in the first half of the year.

　　Ban on sale

　　Internet lottery is banned.

　　The ban on selling lottery tickets on the Internet has also had an impact on lottery sales. The reporter noted that in August 2018, the Ministry of Finance and other 12 departments jointly issued a document resolutely prohibiting the unauthorized use of the Internet to sell lottery tickets.

　　Internet lottery had previously shown a blowout growth trend in 2014. The huge sales volume of nearly 100 billion yuan makes internet lottery purchase an important force to promote the development of lottery market.

　　In 2014, Internet lottery experienced a glorious period. Major sports events, including the World Cup in Brazil, boosted the sales of Internet lottery by 102% from 42 billion yuan in 2013 to 85 billion yuan, accounting for 20% of the total lottery sales. According to the Analysis Report of Internet Lottery Market in 2014, there were more than 100 million users in China who bought lottery tickets through Internet channels, and the Internet became an important betting platform and channel for users.

　　Since then, since 2015, the Ministry of Finance and other departments have repeatedly issued a document to prohibit the sale of lottery tickets through Internet channels. However, during the 2018 World Cup, a large number of mobile apps illegally sold lottery tickets through the Internet.

　　At that time, there were many fish that escaped from the net without being investigated. According to media reports, some apps have stopped selling lottery tickets through the search of "lottery tickets" in Android and Apple mobile phone stores, but there are still many softwares that can buy lottery tickets. In the early days of the World Cup last year, many companies launched online lottery platforms again. Finally, many online football lottery platforms such as "Winning the lottery every day" and "Everyone Winning the lottery" stopped selling on June 20 last year.

　　reform

　　Standardize the management of welfare lottery issuance

　　The corruption case of Fucai Center exposed last year aroused social concern. On November 9, 2018, the website of the Central Commission for Discipline Inspection published a heavy article: "Pay equal attention to reduction and suppression, treat both the symptoms and the root causes, rebuild the credibility of Fucai, and the discipline inspection and supervision team stationed in the Ministry of Civil Affairs will promote the formation of a good political ecology from typical cases", with more than 4,000 words, and released confession videos of four former leaders of China Welfare Lottery Issuance Management Center.

　　Statistics show that since the 18th National Congress of the Communist Party of China, at least 14 people in the civil affairs system have been held accountable for issues related to welfare lottery. Fucai’s anti-corruption has a long time span and a wide range, and has become a case of systematic corruption. In addition to the four leading characters in the confession video published on the website of the Central Commission for Discipline Inspection, four members of the party group, including Li Liguo, former Minister of Civil Affairs, Dou Yupei, former head of the discipline inspection team in the Ministry, Qu Shuhui and Chen Chuanshu, former president of the China Aging Association, were held accountable.

　　After the corruption case of Welfare Lottery, the Ministry of Civil Affairs has improved the management system of welfare lottery issuance, sales, distribution and use of public welfare funds, such as changes in the internal institutions in charge of welfare lottery management.

　　According to the Regulations of the Ministry of Civil Affairs on Functional Allocation, Internal Organizations and Staffing, before the reform, the management of welfare lottery was in charge of the Department of Social Welfare and Charity Promotion; After the reform, the welfare lottery management has been refined, and the planning and finance department and the newly established charity promotion and social work department are in charge.

　　On July 29, the Ministry of Civil Affairs held a press conference, and the relevant person in charge introduced that there are three main reform directions in regulating the issuance and management of welfare lottery tickets. First, cooperate with the Ministry of Finance, comprehensively rectify the unauthorized use of the Internet to sell welfare lottery tickets, and comprehensively carry out self-examination and inspection of national welfare lottery institutions and consignment agents. Second, vigorously adjust the rules of the quick opening game of welfare lottery to resolve the market risks of welfare lottery. The third is to improve the welfare lottery issuance management system.

Blind road is a road traffic infrastructure to help visually impaired people walk. However, in real life, the phenomenon that blind roads are occupied is common, so people with visual impairment often encounter it is hard to go.

What is the crux of it is hard to go’s pain caused by the occupation of blind roads and visually impaired people? How to break the game?

(1)

Blind roads have a history of more than 200 years. The world’s first blind road can be traced back to the early 19th century, designed by a French designer, and it is a kind of pavement that is convenient for the blind to walk.

The first blind road in China was born in Beijing in 1991, with an area of 1,600 square meters. At that time, it was for the convenience of more than 200 blind workers in Haidian Rubber Hardware Factory. Before this, there was an accident that caused quite a stir: because there was no one to lead the way and there was no blind road to "navigate", a blind masseur accidentally fell into a sewage well being excavated on his way home and almost died.

After more than 30 years of development, the blind road has become a necessary item in urban road traffic construction in China. Generally, whenever there is a sidewalk, there is a blind road, but it is obvious to all that it is rarely used by visually impaired people. Is it because there are few visually impaired people? According to the data of the seventh national census, the number of blind people in China has exceeded 17.3 million. According to the latest statistics of Huizhou Disabled Persons’ Federation, there are currently 4,334 people with visual disabilities in the city.

There are almost no visually impaired people on the road, and the blind roads are basically idle all the year round. Cao Yang, chairman of the Municipal Association for the Blind, gave the answer: A considerable number of visually impaired people in Huizhou don’t go out at ordinary times, not because they are unwilling, but because they dare not. One of the main reasons is that the blind roads are occupied and they are worried that they will be knocked or tripped when they go out.

(2)

At the end of last year, Huizhou Daily’s video number "People’s Livelihood Eye" reported the problem of "enclosing and occupying blind roads" at a construction site in Jiangbei, which aroused widespread concern and brought the topic of "occupied blind roads" into public view again.

In cities, similar blind roads are frequently occupied, and the ways of occupation are varied: for example, the blind roads are occupied by motor vehicles and non-motor vehicles, some construction fences occupy the blind roads, and some facilities are directly built on the blind roads. In addition, the out-of-store business, mobile vendors and other "empty nests" make the blind roads "busy", which affects the image of urban civilization and makes it more difficult for visually impaired people to travel.

In September 2023, the results of the "Satisfaction Survey on Barrier-free Environment Construction" conducted by the Municipal Disabled Persons’ Federation showed that 77.71% of the respondents thought that the blind road was seriously occupied, 17.08% thought that the blind road was partially occupied, and only 5.21% thought that the blind road was not occupied.

For visually impaired people, the blind road is a "navigator" and a "life road" to guide them to travel safely, and it is also an important bridge for them to integrate into society and live a normal life. No one or unit can illegally occupy it.

The Law on the Construction of Barrier-free Environment in People’s Republic of China (PRC), which came into effect on September 1, 2023, clearly stipulates: "No unit or individual may arbitrarily change the use of barrier-free facilities or illegally occupy or damage barrier-free facilities."

Although there are laws, blind roads are still frequently occupied. The reason is that on the one hand, the utilization rate of blind roads is low, which leads some people to think that blind roads are unnecessary, so occupying blind roads has become the norm; On the other hand, many people lack the awareness of respecting the blind road, covet convenience, place vehicles or occupy the road. In addition, the design of some blind roads is unreasonable, which leads to the blind road not playing its due role; Relevant departments lack supervision and law enforcement, and lack effective punishment and punishment for occupying blind roads.

(3)

The occupation of blind roads reflects the blind spots of urban civilization. Changing the phenomenon that blind roads are occupied requires concerted efforts.

First of all, blind roads should be set up according to law and maintained regularly. Relevant government departments should plan, design and build barrier-free facilities for blind roads in strict accordance with national regulations and standards. Remind and advocate citizens to jointly protect blind roads. While laying blind roads, you can also spray signs such as "No Occupation" at regular intervals and maintain them regularly.

Secondly, it is necessary to strengthen supervision and law enforcement. Blind roads are frequently occupied, and a big factor lies in the low cost of violation. Relevant functional departments should earnestly shoulder their supervisory responsibilities, strengthen law enforcement inspections, intensify investigation and exposure of malicious occupation of blind roads, and stop uncivilized behaviors, so as to realize a virtuous circle of dare not occupy, can not occupy and are unwilling to occupy.

At the same time, it is necessary to increase publicity and education on popular science. Relevant functional departments should carry out publicity and education through various channels, improve people’s attention to visually impaired groups and awareness of blind roads, eliminate cognitive "blind areas", and enhance citizens’ consciousness of eliminating the occupation of blind roads.

In addition, we should also be good at using the power of science and technology to solve the problem of blind roads. Relevant functional departments can increase the investment in intelligent blind road facilities, such as blind navigation system and electronic guide blind road, to provide more convenience for visually impaired people to travel; You can also use intelligent monitoring and other technologies to monitor the occupation of blind roads in real time, and deal with the occupation problem as soon as possible, and also provide a smooth and safe blind road for visually impaired people.

I hope that through a multi-pronged approach, blind roads will no longer be crowded out, and visually impaired people will no longer "hinder" travel.

Huizhou Daily reporter Luo Guohong

CCTV News:In the first three quarters, the consumer market showed resilience, the market sales scale kept expanding, consumption upgrading continued to advance, and new consumption grew steadily.

In a shopping mall in Jiguanshan Township, Shangli County, Pingxiang City, Jiangxi Province, an intelligent home system attracted the villager Rong Jinwen. Since the beginning of this year, there have been several talking and working appliances in their home. Not only can you buy offline, but with the continuous improvement of rural logistics and commercial facilities, villagers can buy goods with the same quality and price as the big supermarkets in the city without leaving the village through the postal public service station in the village.

According to the data released by the National Bureau of Statistics, the rural consumer goods market has maintained a stable recovery since this year. In the first three quarters, the retail sales of rural consumer goods reached 4,255.2 billion yuan, up 0.9% year-on-year, and the growth rate was 0.2 percentage points higher than that of urban consumer goods. Quarterly, the retail sales of rural consumer goods in the third quarter increased by 3.2% year-on-year.

While the resilience of the consumer market has emerged, consumption upgrading has also continued to advance. In a shop of ski equipment in Ningbo, Zhejiang, the reporter saw that many skiers were buying ski supplies.

The Winter Olympics has ignited the "ice and snow enthusiasm" of southern cities, and more complete ski equipment and more professional ski resorts have become the new fashion of consumers.

State Taxation Administration of The People’s Republic of China Announcement No.41 of 2018

　　In order to ensure the smooth progress of the reform of the national tax and local tax collection and management system and ensure the orderly connection and smooth transition of the VAT electronic ordinary invoice before and after the reform, the relevant matters concerning the use of the VAT electronic ordinary invoice are hereby announced as follows:

　　1. After the listing of the new tax agency, the tax bureaus of all provinces, autonomous regions, municipalities directly under the Central Government and cities under separate state planning in State Taxation Administration of The People’s Republic of China [hereinafter referred to as "the tax bureaus of all provinces (autonomous regions and municipalities)"] will start to use the new invoice producer seal. The invoice producer seal on the format file of VAT electronic ordinary invoice (including toll road toll VAT electronic ordinary invoice, the same below) is correspondingly amended as the invoice producer seal newly activated by the tax bureaus of all provinces (autonomous regions and municipalities).

　　2. The newly-launched invoice producer seal is oval in shape, with a major axis of 3 cm, a minor axis of 2 cm and a side width of 0.1 cm. A thin line is engraved on the inner ring, with the words "National Unified Invoice Producer Seal" engraved on the upper ring, the words "State Taxation Administration of The People’s Republic of China" engraved in the middle, and the words "XX Provincial (autonomous region, city) Taxation Bureau" engraved on the lower ring, for example, "Jiangsu Provincial Taxation Bureau". The font is 7 points in italics, and the printing color is big red. See the attachment for the newly enabled invoice producer seal style.

　　3. Taxpayers should complete the upgrade of self-built electronic invoice service platform and third-party electronic invoice service platform before December 31, 2018. After upgrading the electronic invoice service platform, the format file of the generated VAT electronic ordinary invoice uses the invoice producer seal newly activated by the tax bureaus of various provinces (autonomous regions and municipalities). Before the electronic invoice service platform is upgraded, the format file of the generated VAT electronic ordinary invoice can continue to use the invoice producer seal of the original State Taxation Bureau of all provinces, autonomous regions, municipalities directly under the Central Government and cities with separate plans.

　　Four, the provinces (autonomous regions and municipalities) tax bureau should use a variety of channels, and earnestly do a good job in the publicity and interpretation of the use of VAT electronic ordinary invoices. It is necessary to take multiple measures and make solid progress, timely and accurately inform taxpayers and third-party electronic invoice service platform operators of relevant policies and regulations, and urge them to complete the upgrade of electronic invoice service platform on time.

　　V. Announcement of State Taxation Administration of The People’s Republic of China on Issues Concerning the Implementation of VAT Electronic General Invoice Issued by VAT Electronic Invoice System (State Taxation Administration of The People’s Republic of China Announcement No.84 of 2015 and State Taxation Administration of The People’s Republic of China Announcement No.31 of 2018) The invoice producer seal in Appendix 1 of VAT electronic general invoice sample shall be adjusted according to the provisions of this announcement.

　　This announcement shall come into force as of the date of promulgation.

　　It is hereby announced.

State Administration of Taxation (SAT)

July 23, 2018

Special feature of 1905 film network I don’t know when it became the "punching place" of the film circle.From the summer of 2023,Never Say Never, to the New Year’s Eve fileThe annual meeting can’t stop! 》The interaction, as well as the previous praise of small-budget movies.Galaxy writer,weekstarChi is not absent.

In addition, he frequently warmed up for the new film Shaolin Women’s Football, first recruiting actresses, and then repeatedly with the former women’s football international.a surnameLenaWomen’s international defenderLi JiaYue linkage, it seems that distanceFrom the filming of this new film, it is only a short step. And it’s been a long timeMermaid 2There are also new news, which has been submitted for trial and is expected to meet the audience this year.

"Stephen Chow IP" will also be developed infinitely in the future.

At the beginning of the year, he launched the "9527 Theater" in conjunction with the short video platform, and planned to launch the first work "Golden Pig and Jade Leaf" at the end of May; Another video platform has reached a strategic cooperation with Bigao Group, which belongs to Stephen Chow, and will carry out all-round cooperation in film and television around more than ten classic IPS in Stephen Chow, among which Stephen Chow joined the variety show "king of comedy Stand-up Season"; The film has also been adapted into a series of the same name, starring,, and others.

Stephen Chow is very busy, and Stephen Chow IP is still a hot topic in the film and television circle today.

Just look closely at these follow-up contents. Except for The Mermaid, he seems to be repeating his IP over and over again. Has Stephen Chow really started the mode of "sentimental consumption"?

Stephen Chow’s business experience

The word "Stephen Chow" is undoubtedly valuable in the China market.

In 2013, with one film, the Chinese New Year movie was opened, and the film market in China entered a stage of rapid development. After a lapse of three years, he continued to hit the Spring Festival again with The Mermaid, becoming the first film in China’s film history to break 3 billion box office, and the box office data was not surpassed until the summer of the following year.

Subsequently, Stephen Chow started the movie "Journey to the West" and the Spring Festival in 2017 and 2019, during which Mermaid 2 was launched in the spring of 2018. Although the film Journey to the West is directed by, the key point of the work is "Stephen Chow+Tsui Hark" from creation to release and publicity.

In the past 10 years or so, Stephen Chow has completed the creation and shooting of five films, four of which have been shown to the audience in the Spring Festival that year, with a total box office of nearly 7 billion.

In addition, the classic film series starring it was also restored and re-screened, and the extended commemorative version was re-released in 2017, which won 186 million box office results.

Although the audience never saw "Actor Stephen Chow" in these new films, he always appeared as a director, producer and screenwriter, and the commercial status of "Stephen Chow’s Works" never wavered.

Since The Mermaid, the team started the initiative of not watching movies before the release in the Mainland, and only earned the public’s curiosity with the word "Stephen Chow". Facts have proved that this model was effective until the New king of comedy.

Whether it’s "Demon Journey to the West", "Mermaid" or "A Chinese Odyssey", there will be a saying that "the movie tickets owed to Stephen Chow should be returned" more or less.

Obviously, "affection" is Stephen Chow’s killer skill in the past ten years.

From the series of Journey to the West, to New king of comedy, and even the officially announced Shaolin Women’s Football Team, we can find that these works all inject new vitality into Stephen Chow’s past classic works, and all of them correspond to A Chinese Odyssey, king of comedy and shaolin soccer.

Moreover, it is not difficult to find that the dream played in "New king of comedy" is considered to be the female version of Yin Tianchou, and the plot of "king of comedy" can be seen everywhere in the feature film — — Lunch stalks, foot stalks, folding stools, dead bodies, and "Self-cultivation of Actors".

Even the most classic scene of "I raise you" in the previous work is reproduced by the heroine Dream and Yang Li, a walk-on partner, in the form of a play in the play, and the clip is dubbed by Stephen Chow and Qinzi.

These dense eggs seem to be the hard evidence of Stephen Chow’s "selling feelings".

In almost 10 years’ works, except The Mermaid, which is an original IP, all the other works that Stephen Chow participated in are connected with the classic works of the past.

Nowadays, in addition to film production, Stephen Chow IP has also been developed infinitely.

The "9527" short drama theater originated from the "9527" stalk that appeared many times in Stephen Chow’s works. In the film, the number of Tang Bohu, played by Stephen Chow, who mixed into Washington as a servant was "9527". In the future, there will be more than ten classic IPS for all-round development of variety shows and dramas.

He will be the initiator of the variety show "king of comedy Stand-up Season" in the future, and he will be highly involved in the recording of the whole program. This may become his rare experience in participating in variety shows. Judging from the current official lineup, the show is all around him, the "king of comedy".

It’s just these various projects that make people curious. Has Stephen Chow started to "stir up cold rice"?

"Fried cold rice" or "new creation"?

Applause is always accompanied by doubt.Before the release of "Demon Journey to the West", someone asked him why he filmed it again.WestTravel notes.This even became a question that he was repeatedly asked during the film promotion period. He played his own comedy style and responded, "I just can’t think of anything else to shoot. Hahahaha!"

When it came to "New king of comedy", he was even more exposed to the face and asked if it was fried cold rice.

"I’ve only fried Yangzhou fried rice, but I really haven’t fried cold rice." The playful reply is quite like the "Star Master" in that year.

It’s just his more real original intention. "Twenty years ago and now are two very different environments, and there are many different things, but as some grassroots people, we still need to work hard to fight for our ideals. There is no time limit. It is like this for everyone, and it has never disappeared in my heart."

It is true that apart from the nonsense comedies of Stephen Chow’s signature in these works, he tried to try different contents in his creation.

For example, in the past, A Chinese Odyssey was more nonsense, but in the series of Westward Journey, both he and director Tsui Hark, while continuing the nonsense sign, pushed the style to a more dark and cruel direction.

On the expression of the theme, Stephen Chow once again wrote an epic love beyond life and death, and on the other hand sublimated it to the higher dimension of Purdue beings. He even changed the classic line "Love you for ten thousand years" to "Ten thousand years is too long, just love now".

However, between king of comedy and New king of comedy, apart from the change of gender, the fate of the protagonist also has different stories. Yin Tianchou struggled for a long time, and finally missed success. Dreaming like a dream has a happy ending in "New king of comedy", and even the space about dreaming family is gradually increasing.

In today’s Stephen Chow, I hope the audience can see that life will not be a walk-on forever.

This also makes the outside world particularly curious about Shaolin Women’s Football, which is still being produced. From the title of the film, it seems that it only changes the main role from male to female, but I believe that Stephen Chow’s past creative mode will inevitably make a more contemporary expression at the core of the story.

As for the possibility beyond the film, Stephen Chow always pays close attention to the current technology and creation.

The reason why he cooperated with the platform for short drama theater, he found that short drama is a rapidly developing field of scientific and technological innovation and media innovation in recent years, "because I hope to have new attempts."

Not only that, we can see from the dynamics of his social media that he is also looking for talents of web.30 (decentralized Internet running on blockchain technology) and is studying AI technology, which also makes people curious, whether he will reflect newer technology and ideas in his creation in the future.

It’s just that the current development of other past IPS is based on emotional consumption, but it can’t be ignored that these models are continuing the vitality of the movie IP itself, stimulating the internal driving force of the story in a pan-entertainment way, and interpreting the core of the story with the current era.

For the audience, they want to see the unique charm of Stephen Chow’s works and create more new possibilities after the redevelopment of these IPS. Perhaps only in this form can we truly live up to the feelings of the audience.

Photo courtesy of Tibet Forestry and Grass Bureau of Puruogangri Glacier in Qiangtang National Park Creation Area

Tibet is an important national ecological security barrier, with almost all types of terrestrial ecosystems. Protecting Tibet’s ecological environment is beneficial to the future and the world.

Tibet has included all the areas with the most important ecosystem, the most unique natural landscape, the most essence of natural heritage and the richest biodiversity into the candidate areas of national parks. These areas are also the carriers of the national ecological security pattern of "two screens and three belts" and the important ecological protection and restoration projects of "three areas and four belts", which are of great significance for building the ecological barrier of the Qinghai-Tibet Plateau, protecting the ecological security of China, even Asia and even the world, coping with climate change and protecting biodiversity.

Photo by Peng Jiansheng, a national first-class key protected wild animal.

The uniqueness of Tibet National Park

The candidate areas of Tibet National Park include the world’s highest peak and the most spectacular extremely high mountain group, the largest and deepest canyon, the world’s largest glacial action center except the North and South Poles, the largest alpine desert and alpine grassland, the inland plateau lake with the largest number of lakes and the highest lake elevation, the most developed permafrost area in the middle and low latitudes of the northern hemisphere, and the most unique natural landscape and the most essential natural heritage.

These areas are the core distribution areas of rare and endangered protected species such as Tibetan antelope, wild yak and snow leopard, which have the largest number of wild populations and the richest genetic diversity in the world. They are the gene bank of plateau species, one of the key hotspots of biodiversity conservation in China and the world, and have a very important position in the global alpine biodiversity. These areas are also the unique cultural protection sites of the Chinese nation, and they are the demonstration and inheritance sites of snow culture in the Qinghai-Tibet Plateau and the model of harmonious coexistence between man and nature.

Photo courtesy of Tibet Forestry Bureau of coniferous and broad-leaved mixed forest in Gaoligongshan Mountain

Construction of Tibet National Park

Attach great importance to it for a long time. In 2014, Tibet started basic work such as scientific investigation and resource investigation in the areas of Mount Everest and Qiangtang. In 2021, the Tenth Party Congress of the Autonomous Region proposed to "strive to build two national parks, Mount Everest and Qiangtang, consolidate the good momentum of developing one of the regions with the best ecological environment in the world, and strive to make the construction of ecological civilization at the forefront of the country". Wang Junzheng, secretary of the Party Committee of the Autonomous Region, has successively given instructions such as "actively promoting the construction of Qiangtang National Park, effectively protecting the source of rivers and the water tower of Asia", "deepening the construction of Mount Everest National Park, strengthening the protection of glaciers" and "accelerating the construction of national parks such as Tangbei area of the Three Rivers, Qiangtang and Mount Everest". Tibet has vigorously promoted the construction of national parks, and all work has been comprehensively promoted. At present, the construction of Sanjiangyuan National Park is accelerating, and the candidate areas of Qiangtang and Everest National Parks have been approved by the national reply.

Top-level design, multi-party promotion. Organized and compiled the Demonstration Report of roof of the world National Park Group in Tibet, made the Decision on Establishing a National Demonstration Zone for Ecological Civilization Construction and Accelerating the Construction of Beautiful Tibet, promulgated the Regulations on Ecological Civilization Construction in Xizang Autonomous Region, and issued a series of institutional documents such as Xizang Autonomous Region’s Implementation Opinions on Establishing a Nature Reserve System with National Parks as the Main Body. With the cordial care of the CPC Central Committee and the strong support of the relevant state departments, the administrative areas of Qinghai Province and the areas related to the actual use and management of Xizang Autonomous Region, north of Tanggula Mountain, were included in the scope of Sanjiangyuan National Park, and the mechanism of "unified planning, unified policies, separate management and separate responsibility" was innovatively implemented in the two provinces of Qinghai and Tibet, which greatly promoted the implementation of the overall ecological protection, system restoration, comprehensive management and ecological enrichment project in this region.

Protection first, system governance. The tenth Party Congress of the autonomous region proposed to establish a nature reserve system with national parks as the main body and increase the protection of forests, wetlands and grasslands. Tibet adheres to the integrated protection, restoration and systematic management of mountains, rivers, fields, lakes, grass, sand and ice, strengthens the protection of important river sources and key river basins such as the Yangtze River, the Yarlung Zangbo River and the Nujiang River, maintains the authenticity and integrity of the key protected wildlife distribution areas such as Tibetan antelope and wild yak in China, implements the withdrawal of regional mining rights, and strengthens the management of the ecological environment, which has greatly promoted the protection of biodiversity in the Qinghai-Tibet Plateau.

Government-led, diversified investment. The finance of the autonomous region has arranged a total of 500 million yuan to build 92 high-standard management stations in Qiangtang and Everest, employ 930 professional managers of farmers and herdsmen, and arrange 50 million yuan for monitoring, supervision and ecological management every year. Guangdong Changlong Group donated 100 million yuan in five years, and successively implemented the capacity improvement projects of Tibet Tibetan Antelope Research Center and 73 management stations in Qiangtang Nature Reserve. Tibet Amacang Foundation has equipped 780 professional managers of farmers and herdsmen in Qiangtang with winter patrol clothes. Vanke Public Welfare Foundation has invested more than 10 million yuan to carry out snow leopard monitoring in Mount Everest Reserve. The autonomous region has also implemented a series of major projects, such as returning grazing to wild areas, ecological environment protection and restoration, wetland protection and restoration, compensation for damage caused by wild animals, improvement of wildlife habitats, and establishment of ecological poverty alleviation posts, and gradually formed a government-led and multi-party fund investment mechanism for national park construction and management, which has achieved positive results.

Innovate means and strengthen monitoring. Tibet cooperated with a number of scientific research institutes and adopted advanced technical means. Over the past 10 years, more than 500 people went deep into Qiangtang area for 24 times, wearing 15 sets of satellite tracking collars, installing 2 sets of high-definition intelligent spherical cameras and more than 200 infrared cameras for Tibetan antelope population. The preliminary study revealed the migration law of Tibetan antelope in Qiangtang. The largest delivery room of Tibetan antelope was found, with a population of more than 100 thousand; The drone photographed 60,000 Tibetan antelopes migrating. For the first time, snow leopard monitoring and research were jointly carried out in Everest Nature Reserve, and the continuous monitoring time was 6 years. The survey results show that the suitable habitat area of snow leopards in the candidate area of Mount Everest National Park is about 11,100 square kilometers, and the estimated number of snow leopards is 106-114. In the candidate areas of national parks such as Qiangtang and Everest, scientific research monitoring and evaluation were first carried out.

Pay attention to the platform and increase publicity. Tibet has cooperated with mainstream media such as CCTV to carry out a large-scale scientific research report on "We and Tibetan antelope" for 10 consecutive years, and presented the scene of Tibetan antelope migration and calving to the world audience by more than 200 live broadcasts and recordings. In cooperation with Beijing Forestry University, Vanke Public Welfare Foundation, etc., China introduced the multi-party cooperation mechanism between reserve management bureau, public welfare foundation and scientific research team in snow leopard protection at international snow leopard protection academic conferences such as Kazakhstan and Kyrgyzstan, and global snow leopard and ecosystem. Many times in the "International Snow Leopard Day" public welfare publicity activities, the achievements and progress in the protection of snow leopards on Mount Everest were introduced, and publications such as Little Snow Leopard: Friends of Snow Mountain and Mount Everest: Little-known Secret of Life were published.

Tibetan antelope Xinhua News Agency reporter Jue Guo photo

The future of Tibet National Park

Improve the political position and gather together the national ecological protection strategy. The autonomous region regards the construction of national parks as "the biggest in the country", and as an important part of the construction of ecological civilization, it strives to make Tibet’s contribution to safeguarding the ecological security of the country, protecting the roof of the world, the water tower of Asia, the roof of the world of the earth, and building a national ecological security barrier.

Focus on protection objectives and establish and improve the ecological system. According to the functional orientation, protection objectives, management principles and management subjects of national parks, study and formulate laws and regulations that are compatible with national park laws and regulations, combined with reality, and matched with protection and management tasks, so as to provide institutional guarantee for ecological protection, construction management and ecological enrichment of national parks.

Innovate the development mechanism and gradually realize standardization. Adhere to the principle of natural restoration, give necessary artificial promotion, strengthen the protection site, patrol road network, monitoring and control, emergency relief, forest and grassland fire prevention, pest control, wild animal epidemic monitoring, prevention and control, protection and management facilities construction, establish and improve high-tech monitoring means, promote the informationization and intelligence of protection patrol monitoring, and gradually realize standardization and standardization.

Based on protection and construction, vigorously implement the ecological enrichment project. The candidate areas of national parks in Tibet are located in glacier snow-capped mountains, river headwaters, lakes and marshes, grassland forests, Gobi deserts and areas rich in animal and plant resources. These places are difficult in conditions, location and development. Combined with the construction of national parks, people who have the ability to work will be transformed into ecological rangers on the spot and get paid for their work in ecological protection. Adhere to the ecological protection first, coordinate the relationship between protection and development, moderately carry out eco-cultural tourism, let the people eat eco-food and embark on the road of getting rich in participating in ecological protection construction, and realize the unity of ecological protection, green development and improvement of people’s livelihood.

Innovate the construction mode and continuously enrich the connotation of ecological aid to Tibet. Tibet’s national parks are expected to rank among the top in the country. In addition, Tibet’s harsh natural environment, lack of talents and backward technology have shortcomings and weaknesses in fulfilling the responsibilities of ecological protection and restoration, supervision and management, scientific research and monitoring, and publicity and education of national parks. Exploring and expanding the new mechanism of group aid to Tibet, and effectively increasing the introduction of talents and counterpart support will help to further accelerate the construction of national parks in Tibet, which is of great practical significance for making national parks an important strategic place to build a national ecological security barrier, an important demonstration place to achieve harmonious coexistence between man and nature, an important experimental place to promote green development, an important exhibition place to highlight nature protection, and an important pioneer place to realize ecological enrichment. (Zongga)

Photo by Dong Lei, a national first-class protected wild animal, the brown-tailed rainbow pheasant.

On June 6th, Guangzhou Automobile Toyota’s new car, the 2024 Toyota Willanda high-performance version, was launched. The new car is available in three models with a price of 267,800-301,800 yuan. As an annual modified model, the appearance and interior design of the new car remain unchanged, and the number and name of the car models remain unchanged; The whole system is equipped with a model price increase of 1000 yuan, and a 10-inch HUD head-up display system is added to the whole system.

In addition, the 2024 Toyota Willanda High Performance Edition continues to be equipped with a 2.5L plug-in hybrid system, in which the comprehensive power of the two-wheel drive version is 192kW, the comprehensive power of the four-wheel drive version is 222kW, and the pure electric cruising range of WLTC is 78 km (two-wheel drive version) and 73 km (four-wheel drive version).

The picture is as follows:2023 GAC ToyotaWilanda high performance edition 2.5L four-wheel drive engine version

The 2024 Toyota Willanda High Performance Edition offers three models, namely: 2.5L two-wheel drive engine version, 2.5L four-wheel drive engine version and 2.5L four-wheel drive engine version, and the price is 26.78-301,800 yuan.

In the design part, the front face of the new car continues to use a blackened air intake grille similar to trapezoidal shape (withActive closed system), while the adaptive headlight group remains unchanged. In addition, LED daytime running lights+blackened decorative plates are arranged at the left and right sides of the front enclosure, and blackened+penetrating chrome-plated parts are also arranged at the bottom of the front lip to enhance the visual layering and dynamic properties of the front face.

2024 Toyota Willanda High Performance EditionIts body size is 4665*1855*1690mm, and its wheelbase is 2690mm, so it is a compact SUV.

At the same time, the 2.5L two-wheel drive engine version was used.18-inch two-color wheel hub (225/60 R18), 2.5l four-wheel drive engine version and 2.5L four-wheel drive engine version are used.19-inch bicolor (235/55 R19).

In addition, the new car comes standard with six monochrome car paints (platinum pearl white, black crystal, opal silver, black jade, titanium silver, Yaodong red); And 2.5l Four-wheel Drive Engine Edition and 2.5L Four-wheel Drive Engine Edition also offer 4 kinds of two-color car paints (Platinum pearl white and black, opal silver and black, titanium silver and black, dazzling red and black.）。

In the rear part of the new car, the left and right independent C-shaped taillights are used, and a spoiler+high-position brake light is also equipped above the rear windshield. In addition, the bottom of the rear enclosure is added with black decorative parts and two exhaust systems on both sides, and the overall design echoes the front face, further increasing the sporty atmosphere of the whole vehicle.

In the interior design part, the center console area of the new car is equipped with a three-position steering wheel, a 12.3-inch LCD instrument and a 10.25-inch floating central control panel; And the new car has added a 10-inch HUD head-up display system.

In addition, the new car continues to use the mechanical shift mechanism, and the physical air conditioning button is integrated under the central control panel.

In the car part, the new car comes standard with Toyota.Toyota Space smart space supports CarPlay/HiCar/CarLife smart phone interconnection (wireless connection/wired connection), intelligent online navigation vehicle system, voice vehicle control (window, skylight, air conditioning, navigation, music, Bluetooth phone, etc.) and other functions.

In terms of intelligent driving system, the new car comes standard with Toyota Pilot advanced intelligent driving system, which supports Toyota Safety Sense intelligent driving safety (Toyota Collision Avoidance Assistant Kit), PCS pre-collision system (with front pedestrian recognition), DRCC dynamic radar cruise control system (with full speed domain car following function), ICS intelligent radar with auxiliary braking function and other functions; andThe 2.5L four-wheel drive engine version has also been added.BSM parallel blind spot monitoring system and RCTA reverse side rear blind spot warning system function.

In the seat part, the car adopts a five-seat layout, and the seats are all wrapped with leather+imitation leather.

In terms of seat functionality, the new car comes standard with functions such as electric adjustment of front seats and heating of front/rear seats.

As for the power unit, the 2024 Toyota Willanda High Performance Edition continues to use the 2.5L plug-in hybrid system (the maximum power of the 2.5L engine is 132KW, the maximum power of the front motor of the two-wheel drive version is 134kW, and the total power of the front and rear motors of the four-wheel drive version is 174 kW); The comprehensive power of the system is as follows192kW (two-wheel drive version) and 222kW (four-wheel drive version).

In addition, the new car comes standard with a 15.98kWh ternary lithium battery pack, and the pure electric cruising range under WLTC conditions provides 78 kilometers (two-wheel drive) and 73 kilometers (four-wheel drive).