The price has been reduced so much that Huawei Ascend P7 offers 2332 yuan

    (Zhongguancun online mobile phone channel market reportAugust 22, 2014, China Unicom 4G versionHuawei Ascend P7(licensed goods with invoice) The price is 2332 yuan in the merchant "Honor Online Shopping Mall". The accessories of the machine are: battery (built-in), charger, earphones, data cable, manual, etc. HuaweiAscend P7It is a smart 4G with double-sided gorilla glass.cell phone.

The price has been reduced so much that Huawei Ascend P7 offers 2332 yuan
Pictured, HuaweiAscend P7

    HuaweiAscend P7Use a piece on the front5 inchesFull high definition display screen with a resolution of 1920X1080 pixels, the display effect is clear and delicate. In the core, there is a built-in 1.8GHz HiSilicon Kirin 910T quad-core processor, and a memory combination of 2GB RAM + 16GB ROM. Smooth running Emotion UI 2.3 user interface based on Android 4.4 system, outstanding performance. In terms of taking pictures, there is a 13 million pixel on the back of the fuselageSonySuper lens, and 8 million pixel ultra-wide-angle front lens.

The price has been reduced so much that Huawei Ascend P7 offers 2332 yuan
Pictured, HuaweiAscend P7

The price has been reduced so much that Huawei Ascend P7 offers 2332 yuan The price has been reduced so much that Huawei Ascend P7 offers 2332 yuan The price has been reduced so much that Huawei Ascend P7 offers 2332 yuanPictured, HuaweiAscend P7

Editor’s comment:

    HuaweiAscend P7As Huawei’s flagship mobile phone, the machine uses double-sided gorilla glass in the fuselage, continuing theHUAWEI P6The design of the fuselage looks very fashionable. In addition, the machine is also equipped with a Huawei HiSilicon quad-core processor, and is equipped with 2GB of memory to ensure the smooth operation of the whole machine. Now the machine is priced at 2332 yuan in the merchant "Honor Online Shopping Mall", and friends who like it can consider it.

HuaweiAscend P7(Licensed goods)
[ReferencePrice] 2332 yuan
[SalesMerchant] Honor Online Shopping Mall
[Business phone] 010-57185039 13301099045 
[Store Address] Fangshitong, Muxiyuan, Fengtai District, Beijing

    ??The above mobile phone quotations are actual purchases.Price, if you find that the quotation given by the dealer in this article does not match the text, please call the dismantling phone number: 82616677-8614. (This phone number is a complaint phone number, and product price consultation is not accepted)Due to fluctuations in mobile phone prices, the complaint acceptance period is within 7 days from the date of publication of the article.

    ??Please mention the market when contacting the merchant to buy. The source is Zhongguancun Online.In order to buy a mobile phone at the price quoted in the market.In addition, please remember the name and address of the merchant when purchasing, so that in the event of a dispute, it is convenient to coordinate and deal with it.

??Non-Beijing netizens do not recommend that you trade with merchants online to buy. If possible, please be sure to go to the merchant’s store to experience the real machine before paying.

Q & A responded to the online query: Huawei has invested more than 1,000 people in the R & D team, and the load-bearing capacity of the new M7 model exceeds 630kg.

On September 22nd, AITO asked the car to respond to a series of previous online inquiries, mainly focusing on space performance, chassis suspension, and safety.

IT Home with a summary: According to the "Electric Planet" report, a Li Auto staff member recommended his own L7 model and asked the world for a series of "popular science" for "friendly products".Questioned the performance of the development of the M7 non-new platform, the "oil-to-electricity" model, the suspension chassis, shock absorbers, and ultimate load-bearing

The response from the interrogator is as follows:

Qin L DM-i, a brand-new mid-level car of BYD Dynasty, appeared at Beijing Auto Show.

DM-I, a brand-new mid-size car of BYD Dynasty, made its world debut in auto china in 2024, leading the new trend of mid-size cars in an all-round way with its beauty, leading technology, brand-new platform and excellent intelligence.

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Sword and finger intermediate: the layout of large and small Qin cars completes the map of dynasty cars

The length, width and height of Qin L are 4830mm/1900mm/1495mm respectively, and the wheelbase is 2790mm. It is a standard mid-level car. In the car matrix of the current dynasty, the Qin family is a compact crown and has the right to speak in the family car; The Han family is a medium-sized and large-scale sales champion, ranking first in the mainstream mid-to high-end market, and the Qin L sword refers to the intermediate level, which just fills the matrix gap between the two cars. Upward, attack the joint venture intermediate car headed by Han; Downward, with the formation of a large and small Qin double-car pattern, radiating the A+ market, improving the product layout of Wangchao. com in the mainstream car market.

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Design guidance: dynasty is the tide of the country, showing cultural self-confidenceAs a brand-new mid-level sedan of the dynasty, Qin L was built based on the brand-new orientation of "mainstream, quality and new national tide", drawing strength from Chinese excellent traditional culture, and embodying the perfect integration of national tide culture and future technology. Qin L adopts "the aesthetics of new national tide and dragon face", which melts the dragon and dragon face into the car body, and the dragon face evolves to show the weather of Daqin. The "Dragon’s front face" is majestic, with slender and elegant sides, and the ultra-wide rear shoulder design at the tail, which makes the whole car show a "wide body and low squat" posture, domineering and dynamic.

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The garage is between mountains and seas, and people are in Traveling in a pictorial world. Qin l’s interior is inspired by Chinese painting, creating a "landscape painting cockpit" with high style. The integrated center console slowly unfolds around the rotating big screen, like a long scroll of the East floating on the instrument panel of the sapphire case, creating a strong sense of encirclement. With luxurious space, exquisite materials, ergonomic spacious and comfortable seats, and front McPherson rear multi-link independent suspension, Qin L is beautiful, spacious, comfortable and stable, making driving enjoyable.

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Technology Leading: "Big and Economical" has become the new trend of mid-size cars.

The most anticipated is the technical parameters of Qin L. Previously, Qin L will have a major breakthrough in fuel consumption and battery life. Although the official did not "hammer" at this auto show, it said that Qin L will subvert the stereotype of "fuel consumption" of mid-level cars and lead the breakthrough through technology, making "big and economical" a new trend of mid-level cars.

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Platform leading: the new mainstream of the definition of the strength of a new generation of plug-in and hybrid vehicle platforms

With the acceleration of electrification, the vehicle platform is accelerating innovation. Qin L is based on BYD’s new generation of plug-in and hybrid vehicle platform, and integrates a number of forward-looking technologies, which is designed for plug-in, more efficient, safer and more interesting, and promotes the new energy platform to become the mainstream!

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Leading by intelligence: enjoy the convenience of car life and create a sensory experience of taste

In the era of intelligence, intelligent cockpit and intelligent driving assistance are indispensable. Qin L is equipped with DiLink intelligent cockpit, which is equipped with 15.6-inch adaptive rotating suspension Pad, car ETC, NFC digital key, full-scene intelligent voice, etc. It is smart and easy to control. DiPilot intelligent driving assistance system, including adaptive cruise, intelligent navigation, emergency lane keeping assistance, blind spot monitoring and other functions, comprehensively improves driving safety. With the spacious and luxurious cockpit, quiet space and immersive concert hall, the car life is full of wisdom and taste.

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The arrival of Qin L will lead the new trend of mid-level cars in an all-round way, provide the mainstream families with the choice of upgrading the quality of cars, and provide young people with the one-stop choice of buying cars. It is reported that Qin L will be listed in the second quarter of this year, and it is expected to start selling at 120,000 yuan, which is worth looking forward to!

199,000 is there a play? Xiaomi SU7 configuration exposure: rear-drive version 400V, 73-degree Ferrous lithium phosphate

Fast Technology reported on December 28th that Lei Jun held the first technical conference of Xiaomi Automobile today, announced the latest progress of Xiaomi’s car making, and pre-explained the first model SU7, but did not announce the price of the car.

At the press conference, Lei Jun said that the price of SU7 could not be 99,000, nor would it be 149,000.For the 199,000 cases with the highest voice from the masses,Lei Jun didn’t give a response, so is it possible?

199,000 is there a play? Xiaomi SU7 configuration exposure: rear-drive version 400V, 73-degree Ferrous lithium phosphate

Then, the SKU of the car was exposed on the network, which was divided into two parts: rear motor and dual motor, which were different in power, battery life and configuration.

The rear drive version is equipped with a motor with a maximum output of 299 HP, with a peak torque of 400 Nm, an acceleration of 5.28 seconds at zero speed, a maximum speed of 210km/h and a braking distance of 35.5m at 100-0km/h..

thatEquipped with 73.6 kWh lithium iron phosphate battery, CLTC has a battery life of 668 kilometers.However, the charging speed of the rear-drive version is 400V, and the charging speed is 330 kilometers in 15 minutes.

In terms of configuration, the car is equipped with NVIDIA Drive Orin but driver assistance chip, and the cockpit chip is Qualcomm Snapdragon 8295. It also has built-in Xiaomi 澎湃 OS, which supports Xiaomi Pilot intelligent driving.

The four-wheel drive version, named Max, is equipped with front and rear dual motors, with a maximum output of 673 horsepower and a peak torque of 838 Nm.The acceleration of zero hundred is as fast as 2.78 seconds, the maximum speed is 265 km/h, and the braking distance of 100 km is only 33.3 meters..

It is equipped with 101 kWh Contemporary Amperex Technology Co., Limited ternary lithium Kirin battery, which has a battery life of 800 kilometers under CLTC condition, supports 800V ultra-fast charging and can last 510 kilometers in 15 minutes.

Configuration is very top, suspension +CDC electromagnetic vibration reduction, Brembo four-piston brake calipers, electric suction door for the whole vehicle, 12-way electric adjustable sports seat with active wing support, in addition, it also provides 56-inch HUD head-up display, 25-speaker audio system, active noise reduction, dual NVIDIA driving chip and so on.

199,000 is there a play? Xiaomi SU7 configuration exposure: rear-drive version 400V, 73-degree Ferrous lithium phosphate

In this way,The price of the four-wheel drive Max version is bound to exceed 300,000, and it is also possible to reach 350,000.As for the entry-level version, the starting price of 199,000 seems to have a certain possibility. After all, the Extreme Krypton 007, which was listed yesterday, is 800V, and the starting price is as low as 209,900. Although it is slightly smaller than SU7, its comprehensive strength is still strong.

A customized spring trip for grandparents! Two "Silver Hair" Inter-provincial Tourism Trains in Shaanxi Province

Western Network News (Reporter Chen Jiaxin correspondent Yu Hai Yang Tao) On March 18, two Y172 and Y78 tourist trains loaded with more than 1,700 tourists left Xi ‘an Station, all the way south, heading for Zhanjiang and Taizhou respectively, to start a wonderful spring trip. This is the first time that China Railway Xi ‘an Bureau Group Co., Ltd. (referred to as Xi ‘an Railway Bureau for short) has opened a "silver hair" inter-provincial tourist train this year, and it is also the first time that Shaanxi Railway has opened two trips on the same day.

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In 2024, Shaanxi Railway opened its first inter-provincial "Silver Hair" special train.

In order to help the "silver hair" economic growth and continuously enrich the spare time life of the elderly, Xi ‘an Railway Bureau has further expanded the tourism resources outside the province on the basis of the "silver hair" tourism special train from Xi ‘an to Tongchuan and Yaozhou in the early stage, and provided passenger transport products that meet the needs of the elderly. It is worth noting that the "Silver Hair" inter-provincial tourist train has launched different tourist routes based on the city’s scenic features and surrounding extended scenic spots on the basis of the original "car with people, night tour and scenic parking", and tourists can choose to play according to their preferences.

The special tourist train in Zhanjiang direction includes three tourist routes A, B and C, namely, witnessing Hong Kong, Zhuhai and Macao and traveling around South China, walking in Bama and living for 99 years, and panoramic view of Guangdong and southern Fujian customs, which can not only enjoy the scenery and explore the secrets, but also "buy in buy buy" to meet the rich travel needs of tourists to the maximum extent. The special tourist train in Taizhou direction includes many natural tourist attractions, such as Qianduo Scenic Area, Yingtaozhu Sakura Garden in Taihu Lake, Liyuan Garden, etc., so that tourists can enjoy flowers and boating in March in Yangchun and enjoy the beautiful scenery in spring.

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Elderly tourists ride in an orderly manner.

In order to improve the travel experience of elderly tourists, Xi ‘an Railway Bureau has arranged a special person to provide bus guidance service, equipped with full-time tour guides, and divided teams according to carriages to achieve "one car and one guide", so that passengers can "have a good time and swim with confidence". In addition, the reporter learned that in March, Xi ‘an Railway Bureau will also run tourist trains in popular directions such as Xi ‘an to Huangshan and Enshi, which will help the cultural tourism market continue to heat up.

In the next step, Xi ‘an Railway Bureau will also dig deep into tourism resources and enrich tourism products according to the seasonal characteristics of spring, summer, autumn and winter. On the basis of running the original tourist trains in the province, it will select high-quality scenic spots in various places and carefully design inter-provincial tourist routes, so that traveling by train and by special train will become a new fashion for tourism.

What are the novel tweet authorization platforms? Novel tweet white paper for you to interpret

With the prosperity of online literature and the popularity of social media, the novel tweet authorization platform has gradually emerged, providing a brand-new cooperation opportunity for novel writers and tweets. These platforms not only help authors to expand the influence of their works, but also provide a way for tweeters to gain income. Recently, the novel tweeting agency "Xingzi Booster" released the "White Paper on Novel Tweeting Industry in 2024", which explained in detail the characteristics and operation mode of these novel tweeting authorization platforms for us. Through the industry ecological map in the novel tweet white paper, we can see the important platform and function of each link.
As the first-level authorized organization of novel platforms such as Zhihu, Tomato, UC, Starting Point, Headline, Tik Tok Story, Far Right, Story Meeting, etc., "Xingzi Boost" has carefully interpreted the opportunities and development trends of novel tweet industry from the perspective of the industry. If you want to join the novel tweet industry or an organization/studio that is already in the novel tweet industry, you are also welcome to cooperate with wenlaoshi008.
The White Paper on Novel Tweet Industry in 2024 gives us a detailed interpretation of the main novel tweet authorization platforms in the current market. As a well-known institution in these platforms, Xingzi Boost provides novel writers and tweets with new opportunities for cooperation, helping them to expand the influence of their works and gain benefits. When choosing a platform, tweeters need to make comprehensive consideration according to their own needs and conditions, and choose a platform suitable for them to cooperate. With the continuous development of technology and the continuous expansion of the market, we expect that the novel tweet authorization platform in the future can provide more innovative services and cooperation modes, and create more value for novel authors and tweets.
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A civil servant in Zhengzhou: I also want to work in a cigarette factory. The assembly line is brainless and the salary is high.

Original title: Henan Zhongyan Cigarette Factory recruits workers in the first-line production and operation posts, and 30% of them are masters and highly educated talents. Why do they get together in the assembly line?
Source: Dahe Daily
Tian Yuchen Li Xiaoling Feng Lin
In the past few days, Henan China Tobacco Industry Co., Ltd. (hereinafter referred to as "Henan China Tobacco") released a public list of candidates to be recruited by college students in 2021, which triggered a heated discussion among netizens.
Among them, the company recruited a total of 149 people. Among the 135 people admitted to the "first-line production operation post", in addition to the "985" "211" or "double-class" universities such as China Renmin University, Wuhan University, Zhengzhou University and Henan University, it also attracted master students from universities and research institutes at home and abroad such as Britain, the United States and the Graduate School of Chinese Academy of Agricultural Sciences.
According to statistics, among the 135 students, 41 have master’s degrees, accounting for 30% of the total enrollment. Do assembly line workers in front-line production and operation posts need such a high degree?
Tucao assembly line admits workers, and 30% of them are graduate students. Is it "overqualified"?
In late April this year, Henan Zhongyan published the "List of College Students to be Recruited in 2021" on the official website, which attracted the attention of netizens with the arrival of graduation season.
The reporter found that in 2021, Henan Zhongyan plans to hire a total of 149 people. Among them, 14 people are employed in professional management positions, technology research and development positions and marketing positions, all of whom have master’s degrees, and nearly half of them are from foreign universities, such as Glasgow University, Sydney University, Nottingham University and Durham University.
The remaining 135 people were admitted to the "first-line production and operation positions" of seven cigarette factories, including Jinye Manufacturing Center, Xuchang, Anyang, Nanyang, Zhumadian, Luohe and Luoyang under the jurisdiction of Henan Zhongyan. Among them, in addition to China Renmin University, Wuhan University, Zhengzhou University, Henan University and other "985", "211" or "double-class" universities, it has also attracted graduate students from universities and research institutes at home and abroad such as Britain, the United States and the Graduate School of Chinese Academy of Agricultural Sciences. According to the statistics of the reporters, among the 135 people, 41 have a master’s degree, accounting for 30.37%.
"A graduate student or even a’ returnee’ master goes to a cigarette factory as an assembly line worker. Is this’ overqualified’? To do this kind of work, you don’t need a high degree at all. " A netizen said. The reporter noticed that the focus of netizens’ attention mainly focused on the strong contrast between the graduation school, academic qualifications and the "first-line production and operation positions" of the candidates on the list.
According to the unified requirements of Henan Zhongyan, the candidates for technical research and development, marketing and professional management posts must practice in the Golden Leaf Manufacturing Center for one year after being hired. After being hired, the candidates for the first-line production and operation positions in each cigarette factory must work in the first-line production and operation positions in the workshop for more than 3 years. Even if the relevant functional departments and offices and workshop management posts of each cigarette factory are short of posts, those who have worked in front-line production and operation posts for less than 3 years cannot be transferred to management posts.
It is understood that according to the introduction of official website, Henan Zhongyan, the company has seven cigarette factories under its jurisdiction, with more than 8,700 employees in its main business, producing and selling more than 3 million boxes of cigarettes annually, ranking fourth in the national tobacco industry, with total assets of nearly 40 billion yuan. Official website shows that in 2020, it is estimated that the sales revenue will reach 51 billion yuan and the total tax and profit will reach 35.7 billion yuan.
Explain that the requirement is bachelor degree or above, but the master’s degree is too much, so you can only choose the best one.
A front-line staff member of Henan Zhongyan introduced that the first-line production operations of cigarette factories mainly include "silk making" and "wrapping", both of which are done by operators. Generally speaking, no matter which position, as long as you enter the cigarette factory, you must first start from the front-line workers and understand the tobacco-making process. The main job is to make tobacco leaves into cigarettes for foreign sales.
Generally speaking, cigarette production is also divided into low peak seasons. Because of the particularity of tobacco products, it belongs to planned production. Every tobacco factory and each cigarette category are produced according to the planned and allocated quota. Once the task is completed, there will be no work to do. But sometimes in order to catch up with production tasks, overtime will also occur. "Now, the weather is hot. Take our factory as an example. The production task has also been completed, and the factory has begun to have a holiday."
The staff member said that in the past, most of the front-line workers were junior college and undergraduate, but in recent years, the education of workers has indeed been greatly improved. And this change has a lot to do with the good wages and benefits of cigarette factories. Due to the quota production system of cigarette factories and good welfare benefits, many famous universities and even highly educated people compete for each other. Generally speaking, the recruitment ratio is about 1: 60, and some positions are even higher.
An 8-year-old staff member of Xuchang Cigarette Factory told reporters that not all cigarette factories have good wages. Generally speaking, local cigarette factories that produce tobacco leaves have sufficient raw materials, large cigarette quotas, large production tasks, good benefits and high wages for workers. For example, cigarette factories in Zhengzhou, Luoyang, Xuchang and other places have relatively good benefits and workers’ income will naturally be high. In these profitable cigarette factories, the wages of workers in front-line production positions are often higher than those of relevant functional departments and offices of the company. "The main reason is that workers have more work and higher wages." Take Xuchang Cigarette Factory as an example. Soon after entering the factory, the wages of front-line workers can get 100,000 yuan a year.
On July 14 and 15, the reporter called the human resources department of Henan Zhongyan many times, but no one was connected. However,
Another staff member of Henan Zhongyan, who asked not to be named, revealed that in addition to individual positions such as technology research and development, marketing and professional management posts, their company requires a master’s degree or above, and the recruitment requirements for first-line production and operation positions are all undergraduate or above. When recruiting, it is required to be an undergraduate, but many graduate students have also signed up. Of course, they are selected on the basis of merit. " According to him, some jobs in the tobacco industry are even more difficult to test than civil servants because of their high wages and good treatment.
Take a cigarette manufacturer in Zhengzhou as an example, the wages of front-line production workers can get more than 10,000 yuan per month, and the welfare benefits are better. Therefore, it is welcomed by many college students. "Although it is a front-line worker, the equipment has been automated, and it is basically an assembly line operation. Unlike the previous need for big bags and small bags of tobacco leaves, the work is relatively easy. As long as the production task is completed, you can rest. "
The result of expert market selection reflects the change of talent market structure.
On July 15th, the reporter contacted a graduate student of Henan University, who was admitted to the "first-line production operation post" of a cigarette factory in the province this year. He introduced that he just reported for 2 days, and the company is training them in a unified way, and the time schedule is particularly tight. When asked why he wanted to sign up as a "factory assembly line worker", he said that he signed up after hearing from his family that the salary of the cigarette factory was good and he didn’t think much. When asked about "future plans", he said: "The cost of living is too high now. As long as you can earn money, let’s talk about it first, and then see what promotion channels are available."
"If there is an opportunity, I also want to go to work in a cigarette factory. The assembly line is brainless and the salary is high. It must be very comfortable." A civil servant in Zhengzhou said that due to the particularity of the tobacco industry, cigarette factories have always been regarded as an ideal "iron rice bowl", especially in a populous province like Henan, where the pressure of employment competition is great, making it one of the first choice units for college students to find jobs.
A sociologist of Zhengzhou University also believes that the first-line production and operation positions of Henan Zhongyan Cigarette Factory are favored by highly educated talents, which is also very normal and the result of market choice. At present, the enrollment of graduate students is relatively large, and there is even a surplus of highly educated talents, which also leads to the depreciation of academic qualifications. Take Zhengzhou University as an example. Every year, there are more than 10,000 undergraduate graduates and about 7,000 graduate students, accounting for 41% of the total number of graduates. The proportion of graduate students who graduated from other schools is also increasing. Therefore, it is normal that 30% of the frontline workers admitted by cigarette factories are graduate students. The reason why this information is concerned by netizens is that it is considered as "overqualified". This also reflects the change of talent structure in China, and the number of highly educated talents is increasing. Some people think that this is a waste of human resources, but others think that regardless of the level of work, it is best to suit yourself.
At the same time, the expert also reminded that when choosing a job, college students should consider personal hobbies, future career planning and life planning in addition to salary, and should not only focus on the immediate future, but also ignore the long term.
Reporting/feedback

Visiting relatives from prison during the Spring Festival and seeing off his father-in-law and father, he has no regrets in life/figure

  Li Linping (a pseudonym), a prisoner, never imagined that he had the opportunity to leave prison to visit relatives during the Spring Festival this year. Having a reunion dinner, seeing off my elderly father-in-law and looking after my seriously ill father … Li Linping said that the experience of visiting relatives made him very excited. "I just want to make a good transformation, get out of prison as soon as possible and live a good life again." It is understood that this year’s Spring Festival, 42 prisons in the province organized a total of 274 prisoners to leave prison to visit relatives. Recently, all prisoners who left prison to visit relatives returned to prison on time.


  


  Leave prison: to leave prison freely.


  Li Linping, who is over 40 years old, is visiting relatives for the second time. Compared with the previous experience of visiting relatives, he felt very deeply that he was sentenced to 15 years’ imprisonment for corruption and abuse of power: "This time it is a reward, which is different from visiting relatives outside the prison. There is no full monitoring, and his psychology is very relaxed, and at the same time he has a sense of responsibility."


  In 2004, Li Linping’s mother-in-law died of illness, and he was granted a special leave from prison to visit relatives. From 3 pm to 6 pm that day, Li Linping, led by two policemen, returned to his hometown Qingbaijiang. After knocking on the head several times in front of her mother-in-law’s spirit and hastily comforting her wife and family, Li Linping reluctantly embarked on the way back to prison.


  At the beginning of February this year, Li Linping was pleasantly informed by Jintang Prison that he was on the list of people who left prison to visit relatives during the Spring Festival! It turned out that because of his good performance after he was imprisoned, Li Linping was given the opportunity to leave prison to visit relatives. At 9: 00 a.m. on February 5, Li Linping dressed up completely and excitedly appeared in front of his wife, sister, brother and other relatives. Accompanied by them, he confidently stepped up and walked out of the prison gate for the first time.


  Home: My father-in-law finally waited for him.


  In the morning, Li Linping went to his father-in-law’s house first. The 82-year-old father-in-law was seriously ill in bed. Li Linping came to the old man’s bed and took his hand tightly: "Dad, I came back to see you. Who am I?" After several calls, the old man raised his hand excitedly and said in a trembling voice, "Are you a son-in-law …" "He has been waiting for me, and now he finally sees me." Li Linping said that at noon the next day, the old man finished his life peacefully.


  Youth League Year: For the first time in many years


  At noon on the first day of returning home, a large family had a reunion dinner at their wife’s home. The family kept raising their glasses to bless the New Year and Li Linping. "For so many years, I went home for a reunion dinner for the first time. I am so happy to see a family in harmony. " Li Linping enjoyed this meal so much that he drank a little wine happily, even though he didn’t drink much at ordinary times.


  Filial piety: taking care of father before bed


  Li Linping, accompanied by his family, rushed to the General Hospital of Chengdu Military Region to visit his 84-year-old father almost every day. Because of his careless fall, his father wearing a ventilator could not speak. "Dad, I’m coming to see you. If you know, blink your eyes." Father moved and really blinked a few times slowly.


  "I finally saw the old man for the last time, but I also regretted that I could not be filial." Li Linping said that just after he returned to prison for half a month, his father quietly stopped breathing. He is very grateful to the prison for giving him the opportunity to leave prison to visit relatives, so that he can see the two old people for the last time.


  Significance: Carrying out humanized management.


  Yesterday, the reporter learned from the Provincial Prison Administration that all prisoners who left prison to visit relatives had returned to prison within the specified time, and there was no incident of supervision safety accident and criminals who left prison to visit relatives disturbing social order. Among them, Liu, a criminal in Chengdu Juvenile Delinquency Center, took the initiative to participate in local rescue and relief activities during his visit from prison, and the local town government sent a special letter of commendation.


  "Under the premise of strict standards,’ sunshine’ approval and ensuring safety, visiting relatives outside prison is an important means to improve the quality of criminal reform, which is the embodiment of the criminal policy of’ tempering justice with mercy’ and also conforms to the current advanced execution concept." Li Xinmin, Party Secretary of the Provincial Prison Administration, said.


  Liu Zhicheng, director of the Provincial Prison Administration, said: "Visiting relatives after leaving prison is an important measure to implement humanized management in prisons and an important embodiment of the prison policy of’ reforming people’. We will strengthen the summary, strive to improve and constantly advance." (Reporter Yang Qin)

Editor: Jufu

Do you still need a structural biologist with AI? Wait for the top experts in Shi Yigong to see it this way.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."