The government work report particularly emphasizes that adolescent depression should be intervened as soon as possible.

CCTV News:In the "Government Work Report", in terms of improving the ability of medical and health services, in addition to medical insurance and major diseases that everyone is most concerned about, special emphasis is placed on filling the shortcomings of mental health services. Now our material living conditions are getting better and better, and we pay more and more attention to mental health while satisfying physical health. The report released by the World Health Organization shows that a person’s health is not only physical health, but also mental health.

At this year’s National People’s Congress, the issue of adolescent mental health has once again become a hot topic for many deputies.

The Ministry of Education recently replied to the Proposal on Further Implementing the Prevention and Treatment Measures for Adolescent Depression, and explicitly included depression screening in the contents of students’ health checkups. Some members at the two sessions suggested that depression screening checkups should strengthen the privacy of minors.

       When emo, how do you adjust yourself? Many netizens exchanged some of their own experiences.

 

Perhaps in the eyes of most people, "depression" is a mental illness that adults will suffer from, because the pressure of work and life is relatively high. However, some data show that the number of adolescent depression patients is increasing year by year. In fact, depression may occur at any age, and it has gradually become younger in recent years.

Most adolescent patients with depression have a slow onset, and some teenagers can’t accurately describe their emotions and feelings. They often express their depressed mood through behavior, showing boredom, loneliness and even anger.

Cui Yonghua, Chief Physician of Psychiatry Department of Beijing Children’s Hospital:He will show more behavioral problems. He is often mistaken for a lot of reactions in adolescence, and he is considered to be rebellious or rebellious, so we can rarely clearly identify depression at an early stage.

Childhood and adolescence is a critical period of personality development, and the influencing factors of psychological problems are complex, which are closely related to family, society, school environment, parent-child relationship and other factors besides genetic factors.

Cui Yonghua, Chief Physician of Psychiatry Department of Beijing Children’s Hospital:We set up a good growth atmosphere for children, with harmonious family relations and stable parents’ emotions, and set appropriate individualized learning pressure for children.

Experts remind that many children with psychological problems have already had symptoms, but they have not attracted the attention of parents and teachers. Being naughty or lazy has delayed treatment. In fact, early identification and early scientific intervention are the key to affecting children’s mental health throughout their lives.

Cui Yonghua, Chief Physician of Psychiatry Department of Beijing Children’s Hospital:For mild depression, we prefer psychotherapy; Drug treatment is an important aspect of moderate and severe depression. As long as the drug treatment is scientific and standardized under the guidance of a doctor, there is no need to worry about safety.

Villagers in Shangluo, Shaanxi Province collectively went out to sell blood-stained hepatitis C, and some people tied the grave in advance.

In Shangzhou District, Shangluo City, deep in the Qinling Mountains, there is a remote village, Nanwan Village. Many villagers in the village are suffering from hepatitis C. Because they have hepatitis C, they have spent almost all their savings, and even the whole family is suffering from hepatitis C. Among them, some people have died of vomiting blood because they have no money to treat it, while others are waiting to die …

Hepatitis C, the word has become a nightmare for everyone in the village. Local official surveys have confirmed that many villagers’ infection with hepatitis C is related to their collective experience of "selling blood" in the 1970s and 1980s. Recently, the reporter from Huashang Daily visited the village and had face-to-face communication with hepatitis C patients. Through their stories, we walked into the inner world of hepatitis C carriers.

Villagers selling blood

Cases:

I am afraid that people will "walk away" and my family will tie the grave in advance.

On October 10, the gloomy sky dripped raindrops from time to time, which made people feel depressed and dreary on such a cold day. The reporter from Huashang Daily drove along the country road to Nanwan Village, Dajing Town, Shangzhou District, deep in the mountains. From time to time, older villagers walked slowly, and almost all the young people in the village went out to work.

At a terrace next to a fork in the road, four new two-story houses look very conspicuous. In the yard, 60-year-old Wang Kanliang and his wife sit on stools and look at the nearby mountains. They exchange a few words from time to time. Although the house behind them is newly built, there are few decent pieces of furniture in the house, and there are still infusion bottles hanging at the door of the small house. Since the house was built, the couple became ill. The son went out to work to earn money, and the daughter was married, leaving only the couple at home.

Wang Kanliang and his wife Ding Caifeng are both patients with liver cirrhosis. In 2013, Wang Kanliang went to the hospital for examination because he felt weak and his chest was stuffy, and found that he was suffering from hepatitis C. Despite active treatment, he still developed liver cirrhosis. Last year, Ding Caifeng was also diagnosed with cirrhosis. One day in early September this year, Ding Caifeng suddenly vomited blood. Wang Kanliang quickly called her daughter living in the urban area and sent Ding Caifeng to the hospital. After staying in the hospital for less than half a month and spending nearly 10,000 yuan, Ding Caifeng went home to recuperate.

In fact, the situation of vomiting blood has appeared more than once. In March, Ding Caifeng appeared once. At that time, during the treatment in the hospital, I was afraid that people would "go away" and it was too late to deal with the aftermath, so the family took advantage of it to hoop the grave in advance. In the past two or three years, Wang Kanliang and his wife have lived in hospitals many times. It can be said that they have survived from the gate of hell many times.

"Look, this is my wife and I’s medical diagnosis in recent years, and this pile of medicine. This box costs 3,000 yuan, which is really unaffordable." When Wang Kanliang said this, he bowed his head and was silent for a long time. "I have spent all my money on seeing a doctor. I can’t drag my children any longer. Let fate take its course." Wang Kanliang’s daughter, Wang Jianmin, said that the eldest brother was a farmer who supported his family by going out to work, and her family was in a bad situation. They also wanted their parents to be hospitalized, but the cost was too high. Last time, my mother insisted on being discharged from the hospital, and she originally stayed for half a month.

In front of the hillside not far from Wang Kan Liangjia, a new tomb was just built in July, which was prepared for Wang Kanliang and his wife. People are still alive, but the grave has been strapped, which is quite common in rural areas. Because of the experience of falling ill, the family had to start preparing for the funeral in advance.

The ex-husband died of cirrhosis, and the current husband suffered from hepatitis C.

In Nanwan Village, it is not uncommon for Wang Kanliang and his wife to do so. Lu Shuxia, 57, was hospitalized for hepatitis C in May last year. The diagnosis was viral hepatitis, type C, chronic and moderate. Her current husband has been diagnosed with hepatitis C five years ago, but the situation is slightly better, relying on drugs to maintain, because of fatigue and dull pain in the liver, the couple can’t do farm work at all.

Lu Shuxia is a native of bad karma. Her ex-husband died of cirrhosis 10 years ago. Up to now, she can still clearly remember her ex-husband’s illness. "At one or two o’clock in the evening, I started vomiting blood, and the neighbors quickly used the shelf car to send people to the ditch." Lu Shuxia recalled that after being sent to Mizoguchi, he was taken to a big hospital. After four or five days of treatment, the hospital sent people back again, saying that people were dying and left the next day after returning home. After her ex-husband left, no one did farm work at home, and her daughter was not married, so Lu Shuxia and her current husband (in the same village) came together, but they all got sick later, because they had no money to treat the disease, so they could only take some medicine to maintain it slowly. "I am dying when I am sick. There is no way but to wait for death." Lu Shuxia sighed and looked at the sky helplessly.

A family, four pillars all suffer from hepatitis C.

Hepatitis C is an infectious disease. At first, the villagers didn’t know about this disease. Some people joked and laughed at themselves. "Hepatitis C" thought about whether it was edible biscuits, but more people came later. Everyone gradually learned about this disease, but in the villagers’ hearts, they still didn’t want more people to know, fearing that it would be shameful to spread it. In the early stage, some people didn’t check it, but they carried it at home, and they didn’t actively treat it when they found it. Of course, there is still a more realistic problem here that there is no money for treatment.

"You can report it, but don’t mention specific names. It’s not good to spread it." Luo Shuqiang, a 51-year-old villager, quickly added that it doesn’t matter if there are more people who are sick anyway. Everyone cares about each other, and many folks on the side laughed.

Luo Shuqiang was diagnosed with hepatitis C in June 2015. He spent more than 70,000 yuan on surgery and was treated with interferon at home. For more than a year, he had to take interferon every other day. The side effects of the drug made him feel weak and didn’t want to eat.

Luo Shuqiang is the hope of the family and the main labor force. Now that he is sick, his family is living a very tight life. Luo Shuqiang said that there are four brothers, their father is suffering from hepatitis C, and their eldest brother and fourth brother are also suffering from hepatitis C. All four people in a family are sick, and all four are main laborers, which makes their family unbearable.

The 56-year-old Wang Laishan is thin and weak. His home is not far from Luo Shuqiang’s. The four adobe houses look shabby, and the home is very simple. There are various medicines on the cabinet. His wife is deaf, his eldest daughter is married and mentally ill, and his youngest daughter is married and working in Guangdong. He works at home during the busy farming season and works in Xi ‘an to earn money during the slack farming season.

In March of this year, Wang Laishan felt that his heart ached and he was sleepy. He went to the hospital to check that it was hepatitis C, and then he went to Xi ‘an to review and diagnose hepatitis C. "This is the case in my family. I take care of myself when I am hospitalized. I can’t help it." Wang Laishan said that in order to treat the disease, he has already spent 60,000 yuan. In addition to borrowing from relatives, he also borrowed 30,000 yuan. Now he sells fruits in Xi’ an and buys medicine to maintain treatment. Wang Laishan said that his eldest brother also died of cirrhosis. At that time, he sent his eldest brother away. He was worried about his illness. If something happened one day, I really dare not think about it. ……

Etiology:

In the 1970s and 1980s, some villagers collectively went out to sell blood.

Why are there so many hepatitis C patients in Nanwan Village? According to the villagers’ memories, in 1970s and 1980s, Shangluo, located in the depths of Qinling Mountains, was economically backward, and many people chose to go out to sell blood. All the villagers mentioned above had the experience of selling blood in that era.

"We are relatively poor here. At that time, the’ blood head’ informed the people who sold blood, and then organized everyone to sell blood in Shangluo, Xi’ an and Gansu." Wang Kanliang and his wife Ding Caifeng were still strong young people when they sold blood. They recalled that at that time, in a village, word spread from mouth to mouth, and everyone sold blood in batches. Almost every week, people in the village sold blood. One person could earn 36 yuan by drawing 300 ml of blood at a time. Some villagers regarded blood sales as their main family income because they had no way to earn money.

"Up to now, I can still remember that every time I go, everyone is in groups, talking and laughing, because the mountain people have never been far away, and they also regard selling blood as a pleasure." Ding Caifeng said that after finishing the examination at the place, every time I went to stretch my arm, people began to draw blood. After the blood is sold, the money is given to the "blood head", and everyone can get quilts, bread and other gifts after the blood is pumped. The villagers will take bread home for their children to eat and subsidize their families with the money from selling blood.

The last time Ding Caifeng sold blood was in Tianshui City, Gansu Province. In the early 1990s, she stayed in a hotel for a month and waited in line to sell blood. Finally, after examination, the medical staff told her that she had hepatitis C and could not donate blood. Since then, she has never sold blood again. What disease is hepatitis C? Ding Caifeng didn’t know it at that time, so she didn’t care.

Lu Shuxia also sold blood with her ex-husband, including her current husband. She said that at that time, some people sold blood and some sold plasma. Selling whole blood was a one-time blood donation. Selling plasma was to extract the plasma from the blood after pumping blood, and return the remaining blood protein to the blood seller himself.

This crazy blood selling behavior didn’t stop until the 1990s, and these blood sellers returned to the village one after another. At that time, some people were infected with hepatitis C, but it didn’t attract enough attention.

It is easy to be infected with hepatitis C if the separated blood protein is reinfused.

In 1970s and 1980s, due to economic difficulties, villagers with good health in Nanwan Village successively donated blood in Xi ‘an, Baoji, Weinan, Tianshui, Gansu and Shangluo. Especially from 1975 to 1985, paid blood donation was widespread and frequent, and both whole blood and plasma were donated. From 1986 to 1990, most paid blood donors were eliminated due to unqualified blood, and paid blood donation gradually stopped after 1990.

"Before the 1990 s, blood collection basically did not detect hepatitis C, and technical means could not be achieved in all aspects, just detecting AIDS and hepatitis B." Wang Jianjun, director of the Center for Disease Control and Prevention in Shangzhou District, said that it is more serious to remove the useful components from the blood when collecting blood, and then return the remaining blood proteins to the blood sellers, which is easy to be infected with hepatitis C.

"Shangluo Blood Station was established only after the 1990s. Before that, blood management was in a rather chaotic state. Hospitals needed blood, and people were found through the’ blood head’, and only some simple examinations were conducted on blood donors." Wang Jianjun said that the economy was relatively backward at that time, and selling blood could bring a lot of income, which led many people to "sell blood."

The fact that some people in Dajing Town were infected with hepatitis C attracted the attention of Shangluo City and Shangzhou District, and Shangzhou District CDC launched an investigation. According to the investigation results, they determined that some people in Dajing Town were infected with hepatitis C due to historical reasons. After investigation by Shangluo CDC, it is believed that this does not belong to the category of explosive epidemic, and the relevant specific work is handled by Shangzhou CDC.

Shangzhou District CDC:

A total of 47 villagers were screened, and 40 people were found to be positive for hepatitis C antibody.

A survey report on hepatitis C cases in Nanwan Village of Dajing Town shows that in June this year, Shangzhou CDC, together with Dajing Town Central Health Center, conducted an epidemiological survey and collected and tested blood samples from villagers who claimed to have a history of hepatitis C but had no diagnosis basis. Forty-seven villagers were investigated twice, and 29 blood samples were collected. The results showed that 18 of them had hepatitis C diagnosis certificates from hospitals above the municipal level, and 22 of the 29 samples were positive for hepatitis C antibodies.

In this survey, 47 villagers who reported that they had hepatitis C and had a history of blood donation were investigated. All the respondents had a history of blood donation. In the two surveys, 40 people were screened positive for hepatitis C antibody, ranging from 43 years old to 72 years old, mainly between 51 and 60 years old. According to the investigation, a large number of people in Nanwan Village had a history of blood donation from 1970s to 1990s.

The report concludes that this survey mainly focuses on those who have a history of blood donation. Because of the long time interval, the survey is mainly based on self-report, and hepatitis C is an infectious disease spread in many ways, there is no hepatitis C antibody test during blood donation, and the hepatitis C antibody is not detected in time when blood donation is stopped. It does not rule out the possibility of blood transfusion infection leading to hepatitis C.

Health planning department: increase the publicity of hepatitis C prevention and treatment and increase the proportion of medical reimbursement.

For many villagers in Nanwan Village suffering from hepatitis C, Wang Chao, deputy mayor of Dajing Town, and Guo Ying, president of Dajing Town Central Health Center, said that this was a historical reason. At that time, the sanitary and technical conditions could not be met, and hepatitis C could not be detected when donating blood. They have increased publicity to the villagers to let everyone know how to prevent and treat hepatitis C, and the other is to increase the reimbursement ratio of rural cooperative medical treatment.

Wang Jianjun said that they only received feedback to investigate and did some inspections, but did not conduct a comprehensive survey. According to the existing conditions, the whole region can’t make a thorough survey of all people, only where there are problems and where to carry out work. Shangluo is a poverty-stricken area. According to their preliminary estimation, there were more than a dozen villages selling blood in that year. If it is unrealistic to conduct a general survey, even if it is found out, how to solve it is still a problem.

"In the 1980 s and 1990 s, the masses spontaneously organized blood sales. Under that special background, medical testing conditions could not be met, which caused the current situation." Arjun huang, deputy director of the Health and Family Planning Bureau of Shangzhou District, said that it is an event that belongs to a specific matter and a special background. It admits that the last time they checked Nanwan Village in Dajing Town, 40 people were suspected to be carriers of hepatitis C. This does not rule out that some people are not at home or in other villages. At present, the possibility of hepatitis C infection in Nanwan Village is relatively small.

"One is the infection caused by blood collection, and the other is that some blood is collected during blood collection, and the other blood is returned to the donor’s body, causing infection." Arjun huang said helplessly, at present, there is no census in the whole city, and the specific figures are not known. As a health planning department, it can only be health education, so that the masses can have a preliminary understanding, guide patients to make reasonable diagnosis and treatment, and carry out medical reimbursement in accordance with relevant policies.

Disease control experts: Hepatitis C can be prevented and cured without excessive panic.

"Hepatitis is divided into several types, such as A, B and C. There are many common hepatitis B. Both hepatitis B and hepatitis C are transmitted through blood, mother-to-child and sexual transmission, and belong to Class B infectious diseases." Chen Yanwei, from the Department of Epidemiology and Prevention of Shangluo CDC, said that hepatitis C is mainly transmitted by blood, and its clinical manifestations include fever, digestive tract symptoms and abnormal liver function. The chronic degree is serious, which can lead to fulminant liver failure. Hepatitis C is distributed in all counties and districts of Shangluo. After being infected with hepatitis C virus, it is not easy to be found in time because of its incubation period.

Chen yanwei said that in the past, blood management was not standardized, and some people were infected with hepatitis C in the process of selling blood. Since then, there has been a fundamental change in blood management. "It should be noted that hepatitis C is preventable and treatable. It can be cured by ribavirin and interferon at the initial stage, and patients do not need to be overly alarmed." Chen Yanwei explained that the liver has a strong detoxification function, and the nutrient transformation in the body is completed through the liver, which is equivalent to the "detoxification factory" of the human body. Generally speaking, hepatitis C is a virus, and the liver is characterized by abundant blood flow. The virus invades the liver tissue, and the liver function will be damaged. In the later stage, it is cirrhosis, and in severe cases, ascites due to cirrhosis will eventually lead to liver failure or liver cancer.

(The original title is "Villagers collectively go out to sell blood-stained hepatitis C and someone ties the grave in advance")

The "Prototype Village" of "Action to Break the Ice": How was the cancer removed?

  The prototype of Lin Yao East in the TV series "Action to Break the Ice" — — Cai Dongjia, the former secretary of the Party branch of Boshe Village, once built a mansion that became an unfinished project. Xinhua news agency

  When the police entered the village to catch drug criminals, they were surrounded by a large number of villagers, and clan leaders took the lead in making drugs by holding village affairs … … The popular domestic drama "Action to Break the Ice" has aroused people’s attention to drug control work because of its thrilling story. This story is based on the "December 29" large-scale drug suppression operation in Guangdong at the end of 2013. One of the prototypes of Tazhai Village, the "drug nest" in the play, is Boshe Village, Jiaxi Town, Lufeng City, where nearly 3 tons of ice were seized overnight. Over the past five years or so, the reporter has interviewed many times on the spot and witnessed the changes of Boshe Village. On the eve of International Anti-drug Day, the reporter visited Boshe Village again.

  This used to be a "drug village"

  The seaside is now a contiguous fish and shrimp pond.

  In Boshe Village, the reporter saw that both sides of the road, which used to be full of toxic waste and sewage, are now lush litchi forests full of fruits; The shacks on the beach that used to process and manufacture ice poison have been transformed into contiguous fish ponds and shrimp ponds … …

  Apart from the anti-drug slogans and reward notices that can be seen everywhere, it is difficult for visitors to associate this place with the famous "drug village". At the back of the old village, a newly renovated park replaced the original overgrown barren hill. Cai Xiong, who lives nearby, said: "It used to be dark here at night, but now it has become the villagers’ favorite place." After dinner every day, the villagers dance square dance, exercise, chat and laugh everywhere in the park. Jiaxi Town Central Primary School, located in the northwest corner of the village, has newly built walls, school gates and playgrounds. Not only did the outflow of students come back one after another, but also attracted many students from other villages to study here, and the number of students in school increased from more than 300 to nearly 800.

  Cai Longqiu, secretary of the Party branch of Boshe Village, told reporters that since 2014, the village has rebuilt the "two committees" of the village and gradually carried out normal village-level governance work, and the "poison haze" has also been far away from the villagers. There are a total of 14,000 people in Boshe Village. Today, there are more than 9,000 permanent residents here, and more than 5,000 people go out to work and do business. Most of the villagers who stay in the village are engaged in vegetable, fruit forest planting and aquaculture.

  Tracing back to "breaking the ice"

  More thrilling than the TV play.

  In order to break through the fortified tower village, the police in the play explored the drug situation through informants, undercover and unannounced visits. The struggle to break through the defense line of Boshe Village is much more difficult and dangerous than the TV play. The building pattern in Boshe Village is messy and the interval is narrow. Most of them are "handshake buildings", and every household doesn’t even have a house number. "There are many eyes and ears in the village. Strangers and foreign cars will be tracked by motorcycles when they enter the village. Once they are discovered, they will be abandoned." A local policeman said.

  In 2013, Guangdong anti-drug department secretly dispatched a small number of elite police officers, disguised as "scavengers" and "wage earners", and sneaked into the village to visit the drug-making target at 4 or 5 in the morning. After filming the scene, they took screenshots, positioned themselves, determined the drug-making dens and the addresses of criminal suspects, and successfully found the "gap" in Boshe Village. Lin Weidong, deputy head of the Anti-drug Brigade of Lufeng Public Security Bureau, mentioned to reporters the critical scene of being intercepted and chased by drug traffickers during the investigation: "At that time, someone threatened ‘ Whether it’s a police officer or not, it’s a police officer or a thief who killed him ’ But we didn’t back down, and we found drug-making dens and drug traffickers for the first time. " In the early morning of December 29, 2013, the Guangdong Provincial Public Security Department dispatched 4,000 police officers to collect nets from 69 key targets inside and outside Boshe Village, arrested 182 drug-related elements, smashed 77 drug-making factories and an explosive manufacturing den, and seized 2,925 kilograms of ice, 23 tons of drug-making raw materials, 9 guns and 62 bullets.

  Quite different from the many gun battles at the end of the TV series, although this action was thrilling, it did not encounter much resistance. A policeman who participated in the command at the scene said: "A drug offender had a Grenade by his bed and a gun on his pillow, but we acted quickly. From breaking the door to arresting people, he didn’t have time to react at all, and there was no drop of blood in the whole operation."

  Warrior who sneaked into the drug den

  Someone once paid 2 million for his head.

  "Compared with TV dramas, our investigation work is much more difficult." Lin Weidong, deputy head of the anti-drug brigade of Lufeng Public Security Bureau, said. Lin Weidong was one of the top ten warriors who sneaked into the drug den to make up for investigation. Lin Weidong once participated in the secret investigation of the "Thunder Anti-drug" operation, and recalled the scene at that time. At that time, he was selected as a member of the action investigation team because of his exquisite business and excellent politics, and together with more than 10 other elite police officers, he carried out the investigation of the drug-making dens in Boshe Village.

  Boshe village has dense buildings, messy patterns and narrow intervals, and there is no house number in the village. The roads in the village are narrow and inconvenient. Except for two sections of cars that run through the north and south of the village, the rest sections can only pass tricycles and motorcycles.

  "We gather in Jieyang at 4 o’clock every morning, arrive at Boshe at 6 o’clock in the morning, stay in the village for an hour and then quickly withdraw." Lin Weidong said that in order not to expose the secret actions, after the investigation of the day, they had to go back to work as usual. Boshe village is full of eyes and ears, and the investigating police are often followed by motorcyclists and asked. Lin Weidong and his colleagues in pairs, riding different motorcycles, secretly approached the targets such as old houses and bungalows that made drugs according to the predetermined investigation direction. In order not to be discovered, they often have to disguise themselves for investigation.

  Dangerous moments often happen. He still remembers that during an investigation, he happened to see someone in the house wearing a mask to make drugs. The drug maker immediately took off his mask and called his helper to "kill" Lin Weidong. Lin Weidong and another colleague immediately turned around and fell in the chase.

  After more than two months of investigation, the investigation team finally found out the terrain and the distribution of drug-making dens in Boshe village. On the day of closing the net, Lin Weidong led a team of more than 200 people to accurately find six drug-making dens. "After the closing of the network, someone will spend 2 million yuan to buy my head." Lin Weidong said with a smile, but since he is in the anti-drug business, he must be fearless.

  The "drug war" is not over.

  Drug control is a long-standing cause.

  Action to Break the Ice ends with the arrest and sentencing of Lin Yaodong and others, but the "drug war" in reality does not end there, but the beginning of eradicating the "cancer". In the following two years, Shanwei investigated and dealt with 106 party and government cadres and police officers by initiating accountability and investigating cases, many of whom were "protective umbrellas" for drug offenders.

  In the past three years, many party, government and grass-roots cadres in Lufeng have been investigated and punished for their ineffective anti-drug work. Among them, three town party committee secretaries, one deputy director of the Public Security Bureau and one director of the police station have been dismissed successively for their ineffective anti-drug work.

  At the end of 2018, Lufeng took off the "poison hat" of the "national key anti-drug remediation area", but the anti-drug work did not stop there. One of the key tasks of the local government is to build a long-term anti-drug mechanism and prevent the "drug disaster" from coming back, and one of its key tasks is to help the people find employment as soon as possible. In recent years, the Shanwei Municipal Party Committee and the Municipal Government have held many job fairs in the local area, established a public employment service platform, carried out peer-to-peer recruitment, and helped drug addicts re-employment. The implementation rate of community drug rehabilitation has reached over 95%.

  "Once you are blindly optimistic and do not pay attention to the construction of a long-term mechanism, drug crimes may come back and you must have a sense of crisis." The relevant person in charge of Lufeng Public Security Bureau said that drug control is a long-term cause, and the local authorities will continue to strengthen the construction of grass-roots organizations, guide the broad masses to seek proper careers from the right path, and keep approaching the goal of "a drug-free world".

  According to Xinhua Viewpoint Nanfang Daily and Guangzhou Daily

[See you at 8: 00] "The mortgage is still 100 years old", which is a hot topic for developers to respond.

  CCTV News:At 8 o’clock every day, CCTV will sort out the big and small things that happened around us within 24 hours.

  In 2023, the National People’s Congress and the National People’s Congress will open on March 4th and 5th, respectively. Chinese and foreign journalists are welcome to interview.

The Ministry of Public Security has promoted a special campaign to crack down on and punish internet-related crimes: focusing on naked chat extortion and online routine loans.

China has listed Lockheed Martin and Raytheon Missile and Defense Company as unreliable entities.

The central bank and China Banking and Insurance Regulatory Commission responded that "it is difficult to repay the mortgage in advance": banks should do a good job in service according to the contract.

National Bureau of Statistics: Strengthen the supply and price stability of important commodities for people’s livelihood, and adhere to the positioning of "housing and not speculating".

National medical insurance bureau: support designated retail pharmacies to open outpatient co-ordination services.

Chinese Consulate: Two China students injured in the shooting in the United States are out of danger.

Civil Aviation North China Bureau responded to Shijiazhuang’s multi-flight alternate: a balloon was found and has now returned to normal.

  South Korea released a new national defense white paper, and then called North Korea an "enemy".

Ukrainian ambassador to Japan said that Zelensky intends to visit Hiroshima. Japanese media: Japan may not have invited it yet.

Ukraine claims to have shot down several balloons from Russia: the enemy wants to consume our air defense system.

Suspected of corruption and dereliction of duty, the leader of the largest opposition party was arrested for the first time in the history of Korean prosecutors.

The US Secretary of Transportation blamed Trump for the derailment of the "poison gas train" on the grounds that he abolished a safety regulation on railway operation in 2018.

Musk "appointed" his dog as "Twitter CEO".

  "The mortgage is still 100 years old" is hotly debated. The developer in Nanning, Guangxi denied that it can be up to 69 years old and up to 30 years old.

Zhangjiajie yongding county People’s Procuratorate intervened in the case of a man’s wife who cut her throat in advance.

The Neiqiu County Public Security Bureau in Xingtai, Hebei responded to the man’s flying old man and recorded a video: it is under further investigation.

Zhejiang Xianju police: 2 people were killed and 2 injured in a fight in a vocational secondary school, and the people involved were present.

Shanghai 170-year-old people got bored while waiting for the bus, so they burned the green belt to keep warm. Police: 500 yuan was fined.

The kitchen knife fell from the sky and hit the students: the blade was only one second down, and the police identified it as an accident.

The 42-year-old uncle pretended to be a beautiful woman and cheated the 31-year-old man of 390,000. He was arrested on suspicion of fraud.

Chongqing Yonghui Supermarket was exposed to rats scurrying around on rice, and the municipal supervision department: an investigation has been initiated.

The public said that the rider urinated in front of his house after delivery, and the merchant responded that he had been suspended.

When dealing with this kind of cases, the police and relevant departments should show the powerful force of the rule of law in "anti-domestic violence", standardize law enforcement, strictly enforce the law, make the perpetrators pay a heavy price, let the victims get comprehensive protection, and unite the strong synergy of the whole people against domestic violence and violence.

— — A critical comment on "A woman’s throat was cut after being beaten and aborted by her husband"

On February 15th, Shanghai Yuyuan Lantern Festival ended. It is reported that the Lantern Festival opened on December 26, 2022, attracting about 4 million visitors during the period.

On February 15th, 2023, in Hangzhou, the fish scale dam, a regional watershed comprehensive management project in Linqi Town, Chun ‘an County, was photographed by aerial photography. It was sparkling and the streams were crystal clear, making it a beautiful landscape in towns and villages.

Xu Binshi, an academician of China Academy of Engineering and an expert in maintenance engineering, surface engineering and remanufacturing engineering, died on February 15th, 2023 at the age of 92. Xu Binshi has won 4 first, second and third prizes for national scientific and technological progress, 1 second prize for national technological invention and 11 first and second prizes for military scientific and technological progress. He has published 17 monographs such as Surface Engineering and Maintenance and Nano-Surface Engineering, published more than 300 academic papers and won 11 national invention patents.

  See you at 8 o’clock tomorrow!

  Editor in charge: Huang Zuochun

Editor: Lin Tao Xiao Xiao

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Source: Rolling Synthesis

With the grand opening of the 7th China International Import Expo (China International Import Expo(CIIE)), Tracel Chase has successfully attracted the attention of many consumers and the media with its main natural health and beauty products and the concept of natural environmental protection. Its healthy oral formula with natural extraction as the core has become a bright spot. At the same time, the booth adopts immersive New Zealand natural green plant design, and the product packaging also follows the principle of environmental protection. This series of measures greatly emphasizes the influence and expansion of the brand. During the exhibition, with strong brand charm, Mr Kerrin Harrison, global CEO of Tracel Chase, visited the China International Import Expo(CIIE) booth, was interviewed by CCTV, and had in-depth communication with the leaders of channel partners who visited the booth.

Star products shine on the scene

Natural extraction to seize the oral market

Since its inception, Tracel has been adhering to the initial intention of being healthy and beautiful, and has deeply integrated nature into the brand DNA. CEO——Kerrin Harrison, global CEO of Tracel Chase, said in an official interview with CCTV that China International Import Expo(CIIE) is an excellent platform to fully display the development achievements of New Zealand enterprises. As a natural oral beauty brand originating from New Zealand, Tracel Chase actively participates in the China market, and through the window of China International Import Expo(CIIE), it promotes its healthy oral formula with natural extraction as the core, helping consumers to achieve transparency from the inside out.

Back in 1980, biological experts Wallace Lysaght and his wife founded Tracel, a natural oral beauty brand, whose core advantage lies in using the essence of natural plants. At this exhibition, the star product "Cuisi New Zealand Natural Bright White Drink" made a stunning appearance, selected rare natural ingredients, combined with professional research and advanced extraction technology, and helped consumers realize their good wishes of healthy skin care.

44 years of natural extraction

Drink white from the inside out

During his stay in China International Import Expo(CIIE), the Tracel brand booth attracted a lot of attention. Major media reporters and leaders of channel partners came to the booth to meet with the CEO of Tracel brand on the spot to jointly build a platform for Tracel brand.

Cuisi New Zealand Natural Bright White Drink takes the legendary New Zealand berry Bosenberry as the main component, and also incorporates the essence of six rare natural plants, such as white crystal tomato, red pomegranate, Phyllanthus emblica and olive. It can comprehensively deal with melanin in four stages by blocking, inhibiting, diluting and metabolizing. It can not only block and resist melanin, but also effectively dilute the formed melanin, and accelerate the metabolism of stubborn melanin, thus cultivating Yi Bai’s physique from the inside out. In order to further verify the whitening effect of the product, we invited SGS, an international authoritative third-party organization, to conduct a 28-day efficacy verification test on the product, which proved that the product achieved a series of good effects such as 43.93% improvement in brightness, 41.14% reduction in skin yellowing, 40.49% improvement in skin firmness and 42.86% improvement in skin elasticity after 28 days of continuous use.

Chase New Zealand Natural Bright White Drink insists on 100% natural extraction, 0 artificial additives, 0 hormones, 0 preservatives, 0 fats, 0 artificial sweeteners and 0 pigments, ensuring that every drop comes from the gift of nature, and at the same time, it has passed the double certification of Swiss SGS and Belgian Eurofins authorities, putting natural health into bottles, bringing consumers a pure and unburdened enjoyment experience. It is worth mentioning that Tracel Chase has also obtained the FernMark silver fern certification issued by the New Zealand government, which is not only the official certification of Tracel Chase quality by the New Zealand government, but also a strong commitment to the improvement of consumers’ health and quality of life.

Stimulate opportunities for innovation and cooperation

Deeply cultivate China oral beauty market

With its excellent quality and unique efficacy, Tracel Chase has quickly won the favor of the vast number of young consumers, and has become the new favorite of oral beauty recommended by many bloggers in online celebrity, and has stood out in the fierce market competition.

Tracel Chase aims to make more partners and consumers aware of this 44-year-old natural oral brand from New Zealand with the help of China China International Import Expo(CIIE), a powerful platform attracting worldwide attention, and help the brand to develop continuously in China. At the event site, Mr. Kerrin Harrison had in-depth communication and exchange with key decision makers of key partners who came to the exhibition area, and actively laid out the online and offline omni-channel development map of Tracel Chase.

China International Import Expo(CIIE) provided an important platform for Tracel Chase to communicate with China customers and industry guests. The exhibition in China International Import Expo(CIIE) made more China customers know about Tracel Chase, and more China consumers also experienced the original products from New Zealand and felt the pure and natural concept advocated by Tracel Chase. Looking forward to the future, Tracel Chase will continue to deepen its layout and development in China market, lead the new trend of oral beauty, and bring consumers a healthier and more natural beauty experience!

Reporting/feedback

Learn deeply and use Tianjin Action | Reduce congestion! More than 20 parking lots in Tianjin support ETC charges.

Jinyun News:"ETC payment is successful, bon voyage!" A car leaves the tianjin railway station underground parking lot without stopping, and the license plate recognition and ETC automatic fee deduction can be completed within 3 seconds.
"I came to the station to pick up people. When I left the parking lot, three cars were in front of me, but the vehicles left the scene almost without stopping, which reduced the links of parking, code scanning and payment. ETC automatic deduction is very convenient." Mr. Zhang told reporters.
It is understood that tianjin railway station underground parking lot is divided into front square parking lot and back square parking lot. The front square parking lot has 702 parking spaces and the back square parking lot has 345 parking spaces. The front square is dominated by Liuwei Road exit and Jianguo Road exit, and the back square is dominated by Xinzhao Road exit. Tianjin railway station underground parking lot upgraded its underground parking system from April 1st, updated its intelligent parking machine and added ETC charging device, and began to operate on July 1st.
"In tianjin railway station, the parking peaks are usually from 17: 00 to 19: 00 and from 21: 00 to 23: 00. Instantaneous traffic congestion will cause a short-term parking jam at the exit of the parking lot, with a maximum of nearly 20-30 vehicles. It takes about 1 minute for each vehicle to charge, settle accounts and get invoices, and it takes about 20-30 minutes for the car to pass normally." Li Peng, the person in charge of the parking lot management of Tianjin Jingui Commercial Management Co., Ltd., said that they completed the equipment upgrade without affecting the current operation situation, and all exits of the parking lot were upgraded uniformly, adding the ETC non-stop charging system, which greatly improved the operation effectiveness and effectively alleviated the short-term congestion caused by the centralized departure of railway passengers before the upgrade. Since ETC was put into use, there has not been a large-scale car crash.
The reporter learned that after the upgrading of the underground parking charge system in tianjin railway station, the parking charge methods are more diversified, including not only ETC automatic charge, but also scan code payment such as UnionPay, WeChat, Alipay and manual charge, bringing more convenience to the citizens.
As the main application side of ETC technology, Tianjin Municipal Transportation Commission has taken the initiative to connect the six districts in the city with the municipal health and health commission, the municipal education commission, the municipal bureau of commerce, the municipal bureau of cultural tourism and other departments, actively expand the application scenarios of technology, and organize and promote the construction of ETC payment function for key congested parking lots. At present, more than 20 parking lots with ETC payment function have been built in the city. The ETC parking projects cover transportation stations, hospitals, commercial areas, cultural and tourist attractions and other key areas of people’s livelihood, such as Binhai International Airport, tianjin railway station, Tianjin West Railway Station, General Hospital of Medical University, Airport Cancer Hospital, National Convention and Exhibition Center, Huayuan Road Side Parking Lot, Jizhou Cave Scenic Area, Hedong District and wanda plaza in Binhai New Area.
"At present, the proportion of ETC transactions in various parking lots is about 40%, and the average transaction time is significantly shorter than that of traditional payment methods, which effectively improves the operating efficiency of parking lots and reduces the congestion of parking fees." Chen Yue, a staff member of the Highway Center of the Municipal Transportation Commission, said that in the next step, Tianjin will continue to expand ETC application scenarios on the basis of promoting ETC parking lots, focusing on people’s livelihood areas, such as parking congestion in hospitals and other places, and at the same time, try to actively try and expand roadside parking and other scenarios around car payment. (Jinyun journalist Dong Lijing Photography Wu Tao)
Reporting/feedback

Network broadcast+| General Secretary of the Five Important Issues, this article has been thoroughly explained.

2021年12月8日至10日,中央经济工作会议在北京举行。中共中央总书记、国家主席、中央军委主席最高领袖出席会议并发表重要讲话。

2021年12月8日至10日,中央经济工作会议在北京举行。中共中央总书记、国家主席、中央军委主席最高领袖出席会议并发表重要讲话。

The article emphasizes that in the new stage of development, the internal and external environment of China’s development has undergone profound changes, and many new major problems need to be correctly understood and grasped.

CCTV’s "Network Broadcast+"specially sorts out several major issues mentioned in the general secretary’s article and learns with you.

● It is necessary to improve the employment driving force of economic growth and constantly promote the expansion and quality improvement of employment.

● It is necessary to support the development of small and medium-sized enterprises and give play to their role as owners’ channels.

● We should learn from the lessons of some western countries’ economy "deviating from reality to emptiness", continuously expand the real economy and create more high-quality jobs.

● It is necessary to increase investment in human capital, improve the quality of education, strengthen vocational education and skills training, improve the quality of workers, better meet the needs of high-quality development, and effectively prevent the risk of large-scale unemployment.

We should give play to the function and role of distribution.

● It is necessary to properly handle the relationship between efficiency and fairness, and build basic institutional arrangements for the coordination of primary distribution, redistribution and tertiary distribution.

● It is necessary to adhere to distribution according to work as the main body, increase the proportion of labor remuneration in the initial distribution, and improve the policy of distribution according to factors.

● It is necessary to play the regulatory role of redistribution, increase the adjustment of taxation, social security and transfer payments, and improve accuracy.

● It is necessary to give full play to the role of the third distribution, and guide and support enterprises and social groups that are willing and capable to actively participate in charitable causes, but they cannot engage in moral kidnapping "forced donation".

It is necessary to improve the system of public service policies and systems.

● We must persist in doing our best and do what we can, focusing on improving the level of public services, accurately providing basic public services in areas that the people are most concerned about, such as education, medical care, old-age care, housing, etc., and covering the basic life bottom line of people in need, without raising their appetite or making empty promises.

In practical work, the General Secretary particularly emphasized the following points:

● Set up "traffic lights" for capital.

● We should prevent some capital from growing wildly.

● Anti-monopoly, anti-profiteering, anti-sky-high price, anti-malicious speculation and anti-unfair competition are required.

● It is necessary to strengthen effective supervision of capital according to law.

● Support and guide the healthy development of capital norms.

● We must uphold and improve the basic socialist economic system, unswervingly consolidate and develop the public sector of the economy, unswervingly encourage, support and guide the development of the non-public sector of the economy, and promote the healthy development of the non-public sector of the economy and the healthy growth of non-public sector of the economy.

● It is necessary to implement a comprehensive saving strategy and promote saving actions in various fields.

It is necessary to enhance the production guarantee capacity of domestic resources.

● It is necessary to intensify exploration, implement a new round of strategic action of prospecting breakthrough, and improve the level of development and protection of marine resources and mineral resources.

● It is necessary to define the strategic bottom line of self-sufficiency in domestic production of important energy resources, give full play to the role of state-owned enterprises in supporting the bottom, and accelerate the development and application of advanced mining technologies for oil and gas resources.

● It is necessary to strengthen the construction of the national strategic material reserve system and play a regulatory role in ensuring the bottom line at critical moments.

● It is necessary to promote garbage sorting and recycling, expand the use of domestic solid waste, and accelerate the construction of a waste recycling system.

2022年4月10日至13日,中共中央总书记、国家主席、中央军委主席最高领袖在海南考察。这是10日下午,最高领袖在位于三亚市崖州湾科技城的崖州湾种子实验室考察。

2022年4月10日至13日,中共中央总书记、国家主席、中央军委主席最高领袖在海南考察。这是10日下午,最高领袖在位于三亚市崖州湾科技城的崖州湾种子实验室考察。

It is necessary to optimize the overseas resource support capability.

● We should make full use of the international and domestic markets and resources in a win-win way, strengthen energy resources cooperation with relevant countries on the premise of effectively preventing foreign investment risks, and expand the rights and interests of overseas high-quality resources.

It is necessary to put improving the comprehensive agricultural production capacity in a more prominent position

● Continue to promote the construction of high-standard farmland, carry out the seed industry revitalization action in depth, improve the level of agricultural machinery and equipment, ensure the reasonable income of grain farmers, ensure the absolute safety of rations, basically self-sufficiency of grains, and improve the production capacity and self-sufficiency rate of oil and soybeans.

● It is necessary to comply with laws and regulations, strengthen the construction of financial rule of law, and explore the establishment of a regular law revision system.

● It is necessary to compact the responsibility, "whoever holds the child", compact the local party and government with the same responsibility, and be responsible for maintaining stability and resolving risks in the territory; Consolidate the responsibilities of financial supervision, industry supervisors, discipline inspection and supervision departments, and promote risk resolution according to their respective responsibilities; Compacting the main responsibility of self-help of enterprises and formulating feasible risk resolution schemes.

● It is necessary to strengthen capacity building, improve the level of supervision science and technology, fill the shortcomings of supervision, and strengthen the construction of financial supervision cadres.

● It is necessary to have sufficient resources, promptly set up a financial stability guarantee fund, give play to the role of deposit insurance system and industry guarantee fund in risk disposal, and study and formulate support policies to promote mergers and acquisitions of financial institutions and resolve non-performing assets.

● Local authorities should take the initiative to revitalize existing assets and resolve risks.

● Corporate shareholders should bear the risk loss first until the capital stock is cleared.

● All parties should cooperate extensively, and the financial industry should establish an integrated risk disposal mechanism, fully authorize and coordinate, so as to improve the cross-market and cross-industry co-ordination ability.

● All localities should earnestly shoulder their responsibilities, strengthen supervision, keep the bottom line of no systemic risks, and maintain the stable and healthy development of the real estate market.

2021年9月13日至14日,中共中央总书记、国家主席、中央军委主席最高领袖在陕西省榆林市考察。这是13日上午,最高领袖在国家能源集团榆林化工有限公司年产40万吨乙二醇项目现场考察。

2021年9月13日至14日,中共中央总书记、国家主席、中央军委主席最高领袖在陕西省榆林市考察。这是13日上午,最高领袖在国家能源集团榆林化工有限公司年产40万吨乙二醇项目现场考察。

● Based on the national conditions, coal is our basic national conditions, and the realization of peak carbon dioxide emissions must be based on this reality. While grasping the clean and efficient utilization of coal, we should speed up the flexible transformation of coal-fired generating units, develop renewable energy, promote the optimal combination of coal and new energy, and increase the capacity of new energy consumption.

● We should pay close attention to tackling key problems of green and low-carbon technologies and accelerate the popularization and application of advanced technologies.

●要科学考核,完善能耗“双控”制度,创造条件尽早实现能耗“双控”向碳排放总量和强度“双控”转变,加快形成减污降碳的激励约束机制。

●各地区各有关部门要统筹做好“双控”、“双碳”工作,防止简单层层分解。

●要确保能源供应,实现多目标平衡,多渠道增加能源供应,大企业特别是国有企业要带头保供稳价,决不允许再次发生大面积“拉闸限电”这类重大事件。

●要深入推动能源革命,促进能源消费、供给、技术、体制改革,加强国际合作,加快建设能源强国。

(中央广播电视总台央视网)

Yang Yang fans stand in idolize! Respond to Yang Yang’s "tolerance and criticism" and let him read more books instead of acting.

The TV series "My Human Fireworks" ended, and this TV series, which caused extensive discussion on social platforms and "turned red" in Daxun Wei, ushered in a grand finale. Yang Yang, Wang Churan and Daxun Wei, who are in the midst of the storm, all wrote farewell to the play. Daxun Wei posted the summary in his own hyperbole, and even clicked on his home page in Weibo, but he couldn’t find this post at all, but there were still many fans commenting and praising him.

And here, Yang Yang and Wang Churan’s comment areas are not as cheerful as Daxun Wei’s. Yang Yang wrote "Thank you for your tolerance and companionship, criticism and suggestions this summer", which was met with complaints from fans: "Criticize but don’t listen", "Who tolerated you" and "Read more and don’t act".

Wang Churan’s painting style here is similar, but her tone is much more sincere. "I’m sorry for the trouble caused to you during this time, and I have also received your criticisms and suggestions." Although it is inevitable to be commented by fans, I hope she will restrain her "love brain" and "cherish feathers".

In fact, we can see from here that Wang Churan’s attitude is much more sincere than Yang Yang’s. Obviously, the cousin in "The General is on the Top" and Zhang Guifei in "Qingpingle" are so aura. I hope she can bottom out and come up with good works again.

This movie "My Human Fireworks", which only caught fire with Daxun Wei, two leading actors, Yang Yang and Wang Churan, was ridiculed to the point that the popularity of the road plummeted, and there were too many slots to name one by one. Netizens spit, and I haven’t seen such a "five poisons" drama for a long time.

First of all, there is a big problem with the values of this play. As an adopted daughter adopted by a male and a female family, the female host is rebellious and puppy love because of her strict mother’s discipline, and there is even a minor "sex scene" in the novel.

Some viewers said that because of the broadcast of this drama, it is difficult for many orphans in orphanages to be adopted out, and the "immature baiwenhang" conveyed by this drama has spread to reality.

Song Yan, the male host, is a gangster, and he doesn’t know how to speak properly. He can also yell out such malicious words as "peeling off your skin" at the mother of the female host.

In addition, when men and women get along, they flirt with fire extinguishers when they fall in love, but the content of the woman’s affectionate confession is "I’ll steal hospital anesthetic to die with you when you leave", which is completely inconsistent with their professional qualities as firefighters and doctors, and can annoy a bunch of viewers who are really engaged in these two industries.

Sharp-eyed fans who love to watch the fun rip from the play to the outside. I don’t know, but when they rip, the actors have a big problem. Yang Yang once recommended a bibliography to the audience on a certain program, and even recommended his own photo album! In addition, there is the well-known "Military Art School Grass". In fact, unlike Shen Teng and Sha Yi, he is not an undergraduate in military art, but entered the school as a secondary school student.

Although education does not represent anything, Yang Yang, who has been marketing the title of "Military Art School Grass" to attract many fans, somewhat deliberately hides and touches porcelain. In addition, his understanding of characters and scripts is really simple, and it is not surprising that he is related to his education.

Wang Churan was not spared from being ripped off. The audience who looked at the screen with a magnifying glass found that when Wang Churan and Yang Yang participated in a variety show, because Yang Yang’s performance was unfavorable and the other party was excellent, Wang Churan even rolled his eyes in front of the camera and made no secret of protecting Yang Yang. The audience vomited "She loves it" in succession.

Some fans in Yang Yang’s Weibo comment area suggested that Yang Yang read more books and accept suggestions from the audience. But more fans are boasting like machines, and those touching themselves are piled up like money. Some fans even suggested that he fire Jia Shikai (president of Yuekai) and Muge Li.

Actors don’t reflect on themselves, and fans will only blame this and that, and never consider whether the actor’s own ability needs to be improved. It is no wonder that Yang Yang’s acting skills have always stood still or even regressed. Yang Yang, who is in his thirties, may have never encountered such a "Waterloo" in the past ten years. I hope he can wake up from the "spoil" of his fans and will really be eliminated by the times if he doesn’t improve his acting skills.

Sub-issue of Nature: The mechanism of yogurt’s health benefits, so that’s it.

Original Singularity Cake Singularity Network is included in the topic # Diabetes 20 # Diet is a door to ask 8 questions.

Yogurt reduces the incidence of diabetes, and finally has a scientific basis.

Recently, André Marette team from Quebec Cardiopulmonary Institute of Laval University in Canada published important research results in the journal Nature Communication [1].

They found that adding yogurt to the high-fat and high-sugar diet of obesity-related type 2 diabetic mice can help maintain the dynamic balance of blood sugar in mice and prevent liver insulin resistance and steatosis.

They also revealed the molecular mechanism behind the effect of yogurt: originally, a high-fat and high-sugar diet would reduce the content of metabolites of branched-chain hydroxy acids (BCHA) in the blood and tissues of mice, and a lot of BCHA would be produced during the fermentation of milk into yogurt, so the intake of yogurt could increase the content of BCHA in the liver and blood, and it should be known that BCHA is negatively related to blood sugar and triglycerides.

They also confirmed in vitro that BCHA can indeed enhance the regulation of insulin on glucose metabolism in liver and muscle cells. In addition, the experiment of fecal bacteria transplantation also confirmed that the regulation of yogurt on flora can also improve glucose metabolism, which also means that flora is another target of yogurt to regulate metabolism.

The research of Marette’s team provided a molecular basis for yogurt to improve type 2 diabetes, and found that BCHA in yogurt is the key molecule to regulate liver glucose metabolism in vivo, which proved the mechanism of yogurt to improve type 2 diabetes from the molecular level.

Screenshot of paper cover

Yogurt, as a kind of milk beverage with health care function, is generally made from fermented milk by Streptococcus thermophilus and Lactobacillus bulgaricus, and has been eaten for 4500 years. Yogurt is closely related to human health, and has been reported in many studies to be related to weight loss [2, 3], nonalcoholic fatty liver disease (NAFLD)[4] and the incidence of type 2 diabetes [5-9]. Since yogurt has so many potential benefits, which beneficial ingredients are playing a role?

Some studies have pointed out that yogurt may play a role in reducing the risk of type 2 diabetes through its rich nutrients [10], Streptococcus thermophilus or Lactobacillus bulgaricus and its metabolites [4, 11]. As for the specific metabolites and metabolic pathways involved, it is not very clear. In order to solve these problems, the Marette team conducted a yogurt intervention study on mice with high-fat and high-sugar diet.

They added yogurt to high-fat and high-sugar feed in the form of freeze-drying, replacing 7.6% of daily energy intake. Mice were divided into normal diet control group (C), high-fat and high-sugar diet group (H) and high-fat and high-sugar diet group (Y) with freeze-dried yogurt. They found that compared with the high-fat and high-sugar group, after 3 months, the total energy intake of mice in the high-fat and high-sugar diet group with freeze-dried yogurt decreased and their weight decreased by 2.9%.

Effects of yogurt intake on body weight and energy intake

Subsequently, Marette’s team analyzed oral glucose tolerance test (OGTT) and insulin resistance index (HOMA-IR), and found that yogurt reduced fasting blood glucose and improved insulin sensitivity in mice fed with high-fat and high-sugar diet.

Since sugar metabolism has been improved, where is the target organ of yogurt?

In order to find the target organ of yogurt regulating glucose metabolism, Marette team tested the systemic insulin sensitivity of mice. They found that in the process of insulin injection, the glucose infusion rate (GIR) of mice fed with high-fat and high-sugar diet (H) decreased significantly, and the whole body glucose absorption capacity was lower than that of yogurt intervention group. They also found that yogurt plays a hypoglycemic role by inhibiting liver glucose production (RA) and increasing the whole body glucose metabolism rate (RD). It can be seen that the target of yogurt may be the liver.

In addition, Marette’s team also found that in addition to regulating liver glucose metabolism, yogurt also reduced liver relative weight and triglyceride level, and reduced liver steatosis and fibrosis. The above data show that yogurt intake can protect liver health.

Protective effect of yogurt on liver metabolism and pathology

So which metabolites in yogurt act on the liver and play a role?

Based on the metabonomics method, Marette’s team identified n- acetylglycine, ornithine, n- acetylserine, α-hydroxyisohexyl ester (HICA), 2- hydroxy -3- methylvalerate (HMVA) and α-hydroxyisovalerate (HEVA) from yogurt, which were significant in the liver of mice (Y) who ate yogurt (P≤0.05). Among them, HICA, HMVA and HEVA belong to BCHA metabolites.

During the research, Marette’s team also noticed that high-fat diet could reduce the content of BCHA in blood, liver and muscle of mice. The good news is that eating yogurt can resist the decrease of BCHA content caused by high-fat and high-sugar diet.

BCHA content in different tissues

Since BCHA is the key for yogurt to regulate liver glucose metabolism, what is the relationship between BCHA and glucose and lipid metabolism?

In order to find out this problem, Marette’s team analyzed the correlation between liver BCHA level and fasting blood glucose and triglyceride in mice fed with yogurt, and found that the levels of HICA, HMVA and HIVA in liver were negatively correlated with fasting blood glucose and triglyceride in liver.

In order to verify the regulatory effect of BCHA mixture on glucose metabolism, Marette team verified the effect of BCHA on glucose production and uptake on FAO hepatocytes and L6 muscle cells. The results showed that the higher the concentration of BCHA, the more obvious the inhibition of glucose production in FAO cells, which indicated that BCHA was a regulator of glucose metabolism in liver and muscle cells.

At the same time, Marette’s team also found that BCHA mixture also increased the glucose uptake of L6 cardiomyocytes, among which the metabolite HICA had the most obvious effect. In addition, it was found in vitro that HICA is a cell regulator of glucose production in liver and glucose uptake in muscle, so HICA may be the key metabolite of yogurt to reduce blood sugar in high-fat and high-sugar mice.

Effects of BCHA on Glycometabolism of FAO Hepatocytes and L6 Myocytes

Yogurt intake not only provides nutrients but also lactic acid bacteria. Yogurt itself also has the function of regulating intestinal health. Is the change of sugar metabolism related to intestinal flora? Using the method of 16S rRNA flora analysis and fecal bacteria transplantation, Marette team evaluated the influence of yogurt intake on intestinal flora and the role of flora in glucose metabolism.

They found that yogurt intake increased the α diversity of flora and significantly changed the β diversity. Marette’s team also transplanted different groups of mouse fecal bacteria to sterile mice, and found that the flora of mice in the high-fat and high-sugar diet group with yogurt could improve the insulin sensitivity of sterile mice. Therefore, yogurt not only provides BCHA to directly play a hypoglycemic role, but also participates in hypoglycemic effect by regulating flora.

Changes of flora and results of glucose metabolism in mice transplanted with fecal bacteria under the intervention of yogurt

Generally speaking, the research of Marette’s team shows that the intake of yogurt increases the content of BCHA metabolites in the body, and BCHA acts on the liver, reducing the glucose production in the liver, improving the systemic insulin sensitivity and accelerating the utilization of glucose. In addition, the regulation of intestinal flora is another target of yogurt to regulate glucose metabolism.

It should be pointed out that although this study has pushed our knowledge of the health benefits of yogurt to a higher level, it is a mouse and in vitro cell experiment after all, and further human experiments are needed to confirm these effects of yogurt in the future.

References:

1.Daniel N, Nachbar R T, Tran T T T, et al. Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice [J]. Nat Commun, 2022, 13(1): 1343.

2.Mozaffarian D, Hao T, Rimm E B, et al. Changes in diet and lifestyle and long-term weight gain in women and men [J]. N Engl J Med, 2011, 364(25): 2392-2404.

3.Panahi S, Gallant A, Tremblay A, et al. The relationship between yogurt consumption, body weight, and metabolic profiles in youth with a familial predisposition to obesity [J]. European Journal of Clinical Nutrition, 2019, 73(4): 541-548.

4.Zhang S, Fu J, Zhang Q, et al. Association between habitual yogurt consumption and newly diagnosed non-alcoholic fatty liver disease [J]. Eur J Clin Nutr, 2020, 74(3): 491-499.

5.Kirii K, Mizoue T, Iso H, et al. Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort [J]. Diabetologia, 2009, 52(12): 2542-2550.

6.Drouin-Chartier J P, Li Y, Ardisson Korat A V, et al. Changes in dairy product consumption and risk of type 2 diabetes: results from 3 large prospective cohorts of US men and women [J]. Am J Clin Nutr, 2019, 110(5): 1201-1212.

7.O’Connor L M, Lentjes M A, Luben R N, et al. Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary [J]. Diabetologia, 2014, 57(5): 909-917.

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Also playing the criminal investigation police, Johnny compared with YiBo, and the difference came out.

In the summer of 2022, there were many excellent dramas with criminal investigation themes, including Ice Rain and Fire starring Chen Xiao and YiBo and Punishment for Crime starring Huang Jingyu. The plot directions of Ice Rain Fire and Punishment Crime are different. The plot of Ice Rain Fire mainly revolves around the story of the struggle between the criminal investigation police and drug dealers, while Punishment Crime is a bloody story of the criminal investigation police’s "fighting against evil".

Although YiBo, the hero of Ice Rain and Fire, and Johnny, the hero of Punishment, both play criminal investigation policemen, the actors’ interpretations are different because of their different roles.

Chang Zheng, played by Johnny in Penalty, is the vice captain of the Criminal Investigation Brigade. However, because of his doubts about his father’s "suicide", Chang Zheng has been committed to finding the evidence of the Zhao family. In order to gain the trust of the Zhao family, Chang Zheng risked his life and approached Zhao Pengxiang, the third son of the Zhao family. After a series of efforts, Chang Zheng finally found the evidence of Zhao Pengxiang’s murder and handcuffed him to the police station. Unfortunately, Zhao’s power was too strong.

As a criminal investigation policeman, Chang Zheng is flexible in handling cases, his mind is clear, and his will is even more determined. Before his father was killed, he had told him never to come back if he suffered misfortune, but Chang Zheng was not afraid. For many years, he has been forbearing and dormant. The purpose of Chang Zheng is very simple, that is, to uproot the Zhao family.

In Penalty for Crime, Johnny plays the role of Chang Zheng vividly, and Chang Zheng is flexible, upright and brave, and Johnny interprets it well. In the follow-up plot, Chang Zheng will face a very big test, and the plot of this drama is also very worth looking forward to.

Yu Chen in "Ice Rain and Fire" is a criminal investigation policeman who has just joined the job for a few years, and because he just joined the job, he met Wu Zhenfeng’s father’s case, and Yu Chen was "decentralized" for violating discipline. After returning to the criminal investigation team three years later, Yu Chen decided to catch all the drug dealers who harmed people.

Yu Chen is a very young and intelligent policeman. He is thoughtful and sophisticated. Yu Chen is mature for his age, and the role of YiBo is also very good. YiBo and Yu Chen are also very suitable. After the broadcast of Ice Rain Fire, many viewers said that YiBo’s acting skills have improved a lot with the naked eye.

He also plays the criminal investigation police, because Johnny is a frequent visitor to military film and television dramas, and he has participated in Ace Force, Operation Red Sea’s Action to Break the Ice, etc. In the eyes of the audience, Johnny is a "tough guy" actor, and his preconceptions about playing soldiers and policemen are very close, so the audience’s acceptance of the common signs in Punishment is also relatively high.

YiBo, on the other hand, is different. Since his debut, in many audiences’ minds, YiBo has mainly played idol film and television dramas. Whether it is The Untamed The Legend of Fei or costume drama "The Wind Rises in Luoyang", YiBo’s handsome appearance will make the audience instinctively feel that he is more suitable for Xian Xia drama or idol drama, but in fact, after the broadcast of "Ice Rain Fire", the audience is still amazed by YiBo. The criminal investigation policeman Yu Chen he plays is not as handsome as he looks. Yu Chen is a criminal investigation policeman.

Johnny’s performance in Penalty made the audience impeccable, but YiBo’s performance in Ice Rain and Fire actually brought more surprises to the audience, and he also played the criminal investigation police. Moreover, Ice Rain and Fire and Penalty were broadcast in conflict with each other. Compared with YiBo, Johnny is still very different. Of course, this difference is more due to the different characters and the different souls given to the characters by the actors.

Ice Rain and Fire and Punishment are both wonderful works, while YiBo and Johnny are both mature actors, and their interpretations of the roles are also in place. The two plays have their own wonderful performances, and the audience can still find their own points of view in the plays. As the leading actors in the two plays, YiBo and Johnny, their wonderful performances in the play also add a lot to the play.