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Welcome to Autohome Langfang Promotion Channel, bringing you the latest car purchase discount information. Currently, the high-profile series is undergoing an unprecedented price reduction promotion. Mercedes-Benz GLE models can enjoy up to 50,000 yuan in cash in the Langfang market. The minimum starting price has been adjusted to 649,800 yuan, which undoubtedly provides consumers with an excellent time to buy a car. If you want to seize this rare discount opportunity, you must not miss it. Just click the "Check Car Price" button in the quotation form to quickly get more detailed discount details and make your car purchase journey more cost-effective. Act quickly, don’t let this excellent discount opportunity pass by.

The exterior design of the Mercedes-Benz GLE is full of elegance and power. The front face adopts the classic Mercedes-Benz family design, equipped with an atmospheric single-banner air intake grille, with sharp LED headlights, just like the moment before the cheetah attack, showing a strong visual impact. The overall style is exquisite and sporty, and the body lines are smooth, outlining the noble temperament of a luxury SUV. The details show the fusion of craftsmanship and technology.

The Mercedes-Benz GLE brings out the charm of a luxury SUV with its fine craftsmanship and elegant lines. Its body size is 4927mm * 2018mm * 1797mm, and the wheelbase reaches 2995mm, ensuring a spacious interior and excellent handling performance. The front wheelbase is 1679mm and the rear wheelbase is 1728mm, providing the vehicle with solid stability and balanced driving performance. The unique 19-inch rim with the tire specification of 275/55 R19 not only enhances the visual impact, but also guarantees excellent grip and comfort. From the side, the Mercedes-Benz GLE has smooth lines, showing the aesthetic design of power and elegance.

The interior design of the Mercedes-Benz GLE shows the perfect fusion of luxury and technology. In the cockpit, the steering wheel is made of fine-textured leather material to provide a comfortable grip, and supports manual up and down + front and rear adjustment to ensure the best driving posture. The 12.3-inch central control screen stands in the center, with a clear interface. It integrates multimedia systems, navigation, telephone and air conditioning functions, making intelligent operation easy and convenient. As for the seats, the imitation leather material is wrapped, providing multi-directional adjustment of front and rear, backrest, high and low and waist support. The main and passenger seats are equipped with heating and ventilation functions to ensure the comfortable experience of passengers during long-distance travel. The reasonable distribution of USB/Type-C interfaces, coupled with the wireless charging function of mobile phones, meets the needs of passengers’ electronic devices. The overall interior design highlights the luxury and practicality of the Mercedes-Benz GLE.

The Mercedes-Benz GLE is equipped with a powerful 2.0T turbocharged engine with a maximum power of 190 kilowatts and a peak torque of 400 Nm. The engine has an output of 258 horsepower and a 9-speed automatic transmission, providing the driver with smooth power transmission and excellent performance.

In conclusion, when choosing the Mercedes-Benz GLE, the Autohome owner, in addition to the brand’s influence and the professional service of the sales team, also praised its atmospheric appearance, spacious space and exquisite interior. He said that these advantages make him feel more decent and comfortable during business travel, which is indeed in line with his expectations for luxury SUVs. Therefore, for consumers seeking both quality and service-oriented, the Mercedes-Benz GLE is undoubtedly an excellent choice worth considering.

Welcome to the Autohome Kunming promotion channel, bringing you an exciting news: this luxury SUV is having an unprecedented promotion in Kunming. It is understood that this promotion is as high as 130,000 yuan, making the original starting price of 242,700 Cadillac XT5 even more attractive. This good news undoubtedly provides a rare opportunity for consumers in Kunming to buy a car. If you are interested in this model, don’t miss this once-in-a-lifetime price reduction opportunity. Click "Chatti Car Price" in the quotation form to act now and get a more affordable car purchase price!

The exterior design of the Cadillac XT5 inherits the brand’s usual luxury and dynamism. The front face adopts a family-style shield-shaped air intake grille, with eye-catching chrome decoration, showing a strong brand identity. The body lines are smooth, full of power, and the overall style is both sports and business. It reflects exquisite craftsmanship without losing the luxury temperament, leaving a deep impression.

The Cadillac XT5 exudes elegant body proportions with its refined side design. The body length reaches 4813mm, the width is 1903mm, the height is 1682mm, and the wheelbase is 2857mm, giving it a sense of spacious space and a dynamic body profile. The front and rear wheel tracks are maintained at 1645mm, ensuring stability and driving performance. The tire size is 235/65 R18, which not only combines comfort but also reveals the fine details of the luxury car series. The wheel rim design incorporates the unique style elements of Cadillac, adding a touch of sports to the overall shape.

The interior design of the Cadillac XT5 shows the perfect fusion of luxury and technology. The exquisite leather steering wheel provides a comfortable grip, supports manual up and down and front and rear adjustment, and is equipped with an 8-inch touch center screen. It has a built-in automatic speech recognition control system, which is convenient for the driver to operate multimedia, navigation, telephone and air conditioning. The seats are made of high-quality imitation leather and genuine leather. The main and passenger seats are equipped with 4-way adjustment, including front and rear, backrest, high and low waist support, and the driver’s seat is also equipped with power seat memory function. The second row of seats also supports front and rear adjustment and backrest adjustment to meet the individual needs of passengers. The car is equipped with USB and Type-C ports, and there are two in the front and rear rows for easy connection of passengers. These details reflect the comfort and practicality of the XT5 interior.

The Cadillac XT5 is equipped with a powerful 2.0T engine, which reaches a maximum power of 174 kilowatts and provides a strong output of 237 horsepower. This engine is matched with a 9-speed automatic transmission, which ensures smooth power transmission and driving pleasure. At the same time, the maximum torque is 350 Nm, which fully reflects the strength of the XT5 in terms of performance.

Summarizing the owner’s evaluation, the Cadillac XT5 won his favor with its atmospheric appearance and unique design details, especially the chic lighting design, which undoubtedly added to the charm of the vehicle. As an American model, the XT5 successfully demonstrates the essence of the Cadillac brand, making its identity recognizable at a glance. This has undoubtedly become one of the key factors for the owner to choose it.

The guide price 21.99-28 9,900 yuan, and the most popular SUV new car Avita 07 was officially listed in September.

As the blockbuster new car of the year 2024, the Avita 07 carries too many expectations.

On the product itself, Avita 07 really did not disappoint, the future aesthetic original design is very forward-looking, the golden ratio of the body shape of the wind resistance performance is good, the natural inspiration of the five kinds of paint texture outstanding, multi-screen linkage of the surrounded cockpit both luxury and sense of technology, Kunlun Extended Range Technology quiet industry-leading, Taihang chassis solid and comfortable sports, Hongmeng cockpit + Huawei intelligent driving like a tiger, the British treasure 7.1.4 panoramic sound speaker is the icing on the cake, Avita 07 This car itself can be said to be worthy of tens of thousands of followers.

But there is no doubt that the pricing of Avita 07 has clearly failed to respond to the eager expectations of some tower fans and quasi-tower fans for months.

Of course, this doesn’t mean that the starting price of Avita 07 is too high. The picture shows that the car still feels that the starting price of Avita 07 is in line with expectations, but the corresponding configuration does not match the price very well, resulting in the entire car series configuration looking rather awkward.

Take the extended range version of Avita 07 as an example.

Avita 07 Extended Range Edition launched a total of 3 configuration models, Pro version guide price 219,900 yuan, Max version guide price 239,900 yuan, Ultra four-wheel drive version guide price 279,900 yuan.

The Pro version and the Max version are 20,000 different, what is the difference? The picture shows that the car probably pulled the configuration table, mainly missing the optical ambient light flow/rhythm mode, intelligent fragrance system, 9 speakers and Huawei ADS 3.0 high-order intelligent driving system These items, and according to the configuration price of Huawei ADS 3.0 high-order intelligent driving system, the difference between the Pro version and the Max version is really not much, and the price difference 20,000 is not outrageous. If the price difference is reduced to 10,000, more people may pay.

But the price difference of 40,000 yuan between the Max version and the Ultra version is somewhat confusing. This 40,000 price difference in hardware is as follows: 131kW front motor, air suspension + CDC electromagnetic vibration damping, rear privacy glass, rear seat ventilation/massage, 21-inch sports multi-spoke wheels, 265/45 R21 Continental EC7 silent tire.

Then the Ultra version can be added with an optional optical technology package (HALO interactive screen, ultra-clear electronic external rearview mirror, double 6.7-inch high definition rearview screen, intelligent welcome motion graphics outside the car), while the Max version is not optional.

In all fairness, the price difference between the Max version and the Ultra version of 40,000 yuan is quite large, the rear privacy glass and the rear seat ventilation/massage are not much money, 20/21 inch tires are Continental EC7 silent tires, 4 tires The price difference is only 800 yuan, so this 40,000 can basically be regarded as the price of 131kW motor and air suspension + CDC electromagnetic vibration damping, is this reasonable?

According to the figure, Avita 07 Extended Range Edition needs to push the Max version of the 239,900 yuan, but the Max version is worse than the four-wheel drive system, the price of the 239,900 yuan Extended Range Rear Drive is higher, if 225,900 the basic pre-order explosive, 22.99 can also be accepted, or the ideal configuration should be the Max version of 239,900 yuan plus a front motor upgraded to the Extended Range Four-wheel Drive version, air suspension + CDC electromagnetic vibration reduction as an optional configuration. But change the hardware, it is difficult.

The price of the Ultra extended range four-wheel drive version of 279,900 yuan also seems to be slightly higher, but it can be configured through the standard air suspension + CDC electromagnetic vibration reduction, rear privacy glass, rear seat ventilation/massage, 21-inch sports multi-spoke wheel hub, 265/45 R21 Continental EC7 silent tire, ultra-clear electronic external rearview mirror, double 6.7-inch high definition rear view screen and Max version to open the ladder difference.

In this case, the price system of Avita 07 Extended Range Edition is much more reasonable. The 219,900 Pro rear drive version is mainly used to lower the starting price, while providing some low-budget users with the opportunity to get on the bus.

And the 239,900 yuan Max four-wheel drive version is bound to be the main sales model, Huawei ADS 3.0 high-end intelligent driving + 25 Yang British treasure audio this set is still very good, put the same level to go completely not cowardly, and then Ultra four-wheel drive version is mainly for users with higher requirements to provide personalized choice.

Of course, now the Avita 07 has been officially launched, and the two-wheel drive and four-wheel drive are quite poor in terms of mechanical layout, and the difficulty of modifying the promotional materials is not small, and the cost of modifying the version configuration is too high. And referring to several new cars re-released by friends, after the re-release, sales are still on the street, so the choice left to Avita 07 is to reduce the price. Of course, these still depend on the data of Dading, and it cannot be ruled out that there are many people who pay the bill. After a night of mental struggles, there are also many people who compromise.

It’s not that there is no such thing as an overnight price reduction for a new car. A while ago, a medium and large sedan next door was too popular to unsubscribe after it went on the market, and then the price was reduced overnight. Of course, the price adjustment is not obvious, but by modifying the rights and interests to adjust. But Avita’s optional package is still relatively special. The three optional packages currently provided can be said to be irrelevant. Even if you take it out and give it away, it will not increase much attractiveness. It is puzzling that the more attractive air suspension + CDC electromagnetic vibration absorption has not been taken out as an optional package.

If the air suspension + CDC electromagnetic vibration damping is taken out as a comfortable optional package and then given to the Max version for a limited time, and then a 2,000 yuan deduction for the last 12,000 yuan, then the 239,900 yuan range extension Max actually has a lot of explosive potential. Of course, this is a bit wishful thinking, which is also inappropriate, and car companies also need to make money.

The price reduction of the Pro version is quite troublesome. The configuration and price of the Pro version are very embarrassing. Medium-sized extended-range SUV, single-motor rear drive, 39-degree lithium iron phosphate, Huawei dry + ADS SE visual smart drive… If I guess, I must be the first to think of the dark blue S07 285Max dry + smart drive version, right? And the CLTC pure electric battery life of the dark blue S07 is even better, 285 kilometers.

The guide price of the dark blue S07 285Max smart driving version is 191,900 yuan (the guide price after equity is 181,900 yuan), so this makes the Avita 07 Extended Range Pro version very embarrassing, you say drop 20,000, then 199,900 yuan is not and the dark blue S07 285Max smart driving version played together? If you drop 10,000, 209,900 yuan is still not enough to see, the 25 Yang British treasure to the Pro version can also be considered.

To sum up, the figure said that the car believes that the configuration of the Avita 07 extended range version is too difficult and too late. The most realistic option is to quickly modify the price equity, which is estimated to increase the data of Dading.

Again, it depends on Dading’s data. What if there are a lot of people buying?

1905 movie network news The adventure animated movie "Galaxy Baby" was officially set for April 17, 2021, and the poster was released. In the picture, the V5 team and the witch crow team were lined up on both sides, and the V5 team captain Xingbao and the witch crow were in the center of the poster, transforming into a mecha fighting state. The two launched their fists, and a battle was imminent!

Hardy Star encounters energy crisis V5 team gathers to attack

There is a robot-inhabited planet in the Milky Way, Hadi, because Hadi is facing a huge energy crisis. Dr. Rhino sent Xingbao to lead the V5 energy team to Earth to recover the "Mengdora Crystal" to ease the energy crisis on Hardy. Along with the energy team, there was also the villain who came for the Mengdora Crystal – the Witch Crow Squad. After the first confrontation, the Witch Crow Squad fled. Weiji from Earth took Xingbao and his party to the museum to find the crystal, which helped Weiji and Xingbao defeat the Witch Crow Squad again. However, things are far from simple, and there is actually another conspiracy behind the search for the crystal…

On the poster released this time, the V5 team and the Witch Crow team are in the vast galaxy, and they seem to be fully prepared to snatch the spar. The protagonist Xingbao and his "nemesis" Witch Crow transform into mecha form, looking handsome and full of combat meaning. The picture conveys a strong battle atmosphere, and the interstellar war is about to start, and the final winner is curious.

The Galaxy Guard War is about to start, a must-see for parents and children

In addition to the exciting battle, the film is also well-prepared in the setting of the story. The girl Weiji siblings from the human world and the V5 team go to the galaxy together to make efforts to defend the earth. The two world elements collide into fierce sparks in the film. Who can win the final victory, and what kind of secrets are hidden behind the spar, the answer will be revealed in the galaxy defense battle full of sweat and laughter on April 17.　

In "Galaxy Baby", there are not only hot-blooded battle scenes, but also a lot of astronomical and humanistic knowledge hidden. Elements such as the Sphinx, the Pyramid, and the Milky Way appear one by one, bringing the audience a rich viewing experience and enlightening the children’s understanding of the world. In addition, the team spirit of the V5 team and the burning battle to protect the earth in the film are highly watchable, which can be said to be the most suitable film for parents to watch with their children.

Adventure family animated movie "Galaxy Baby" will be released nationwide on April 17, 2021, a battle full of blood and passion to defend the galaxy is about to begin.

1905 Movie Network News Recently, on the occasion of his 34th birthday, actor Han Geng posted on Weibo: Hello, 34 years old, hello, my girl, and @actor Lu Jingshan, officially publicizing their love affair. Lu Jingshan also responded quickly: Hello, my boy, and @Han Geng, the two of them hit the public with this shocking sweet bomb. In addition, Jing Tian and Zhang Jike, Zhao Liying and Feng Shaofeng, Han Dongjun and Lv Jiarong also spread news one after another.

　

Han Geng and Lu Jingshan: When love comes, you can’t stop it

It is reported that Han Geng and Lu Jingshan met at the Golden Rooster Festival last year. At that time, Lu Jingshan and Han Geng presented the Best Music Award together, interacting on the same stage. When they went down the stairs, Han Geng carefully supported Lu Jingshan, who was very gentleman. Afterwards, Lu Jingshan also sent a Weibo special thank you to Han Geng, as a netizens said: "When love comes, you can’t stop it."

　

Jing Tian and Zhang Jike: All kinds of real hammers are not far from the truth

Recently, the news about "Jing Tian and Zhang Jike are together" was exposed on the Internet, but so far, neither of them has responded to this. However, according to some mysterious netizens, they originally planned to announce their love news on New Year’s Day, but because of the Li Xiaolu PGone incident, it was put on hold. However, now that the evidence on the Internet is flying, all kinds of real hammers should not be far from the truth.

　

Zhao Liying and Feng Shaofeng: Showing up in a hotel in a couple’s outfit and spending the night at home

It is said that Feng Shaofeng and Zhao Liying became attached to each other due to their collaboration in the film. After the play was completed, the two interacted a lot. Recently, the two also filmed together "Do you know if you should be green, fat, red and thin". After that, the two were photographed many times in a couple’s outfit and appeared in a hotel, staying at home for the night, but neither party responded.

　

Han Dongjun Lv Jiarong: I have met the parents of both parties who are about to get married

It is said that Han Dongjun and Lv Jiarong met for filming "Life is like the beginning", and then they were photographed by national talent scouts for intimate dating photos and exposed their relationship. However, both sides publicly denied their relationship, saying they were just good friends. However, many Weibo marketing accounts have revealed that the two are emotionally stable, have met their parents, and are about to get married. Neither side responded.

The annual CCTV Spring Festival Gala is in a fiery rehearsal, and the invited stars have arrived at the scene one after another, and their every move has become the focus.

Liu Tao, a well-known actor, said on the show that she finished "Flowering Flowers" in one go this weekend. She also joked: "I met Hu Ge and Tang Yan at the party yesterday, and couldn’t help but ask Tang Yan: Has the cast of" Flowering Flowers "received an invitation from CCTV for the Spring Festival Gala? After listening to it, Tang Yan replied: I have to ask director Wang Jiawei about this. Hu Ge, who was next to him, said humorously: Thank you! If the crew is really invited, you will be the first person who will think of you when director Wang Jiawei shoots next time. After Hu Ge finished speaking, he laughed out loud!

Although the TV series "Flowers" has ended, the topic is still very popular. So far, there are no rumors on the Internet that the crew of this drama has been invited to participate in the CCTV Spring Festival Gala. Some actors have participated in the CCTV Spring Festival Gala.

In 2016, Hu Ge and Xu Ruyun sang "Love Each Other".

In 2017, Hu Ge and Wang Kai sang "At This Moment".

Although actors have talents not only in acting, but also other talents, they also have their own strengths and weaknesses. To be honest, Hu Ge has seen a lot of acting, but rarely heard singing. Exactly how his singing skills are, the benevolent see the benevolent, and the wise see the wisdom.

Brother Hu played the role of Ah Bao in "Flowers". When he was young, he was very lucky to meet "Uncle". He was willing to teach him how to be a person and how to do things in society, which made him rise quickly in the circle. Brother Hu’s acting skills were beyond doubt, and he accurately controlled the emotions and details of the role of Ah Bao.

In 1984, You Benchang performed the mime "Shower Man" on the stage of the CCTV Spring Festival Gala. His silent performance on the stage was very natural and vivid. To put it bluntly, his acting skills are solid. Unfortunately, there are almost no mime performances now.

In 1987, you Benchang performed the sketch "Sun Erniang Opens a Shop" on the stage of the CCTV Spring Festival Gala. This time he played the female character "Sun Erniang".

In 1988, you Benchang performed a sketch "Emergency" with Zhao Lirong, Wang Liyun and others. It mainly talks about how to raise children, and their interpretation is very real and funny.

In 1985, you Benchang starred in the role of "Ji Gong", which became popular all over the country. In the play, although he was dressed in ragged clothes and held a broken fan in his hand, he was very kind-hearted and willing to help disadvantaged groups in society. You Benchang played this role very smartly and became his classic role.

Counting, You Benchang is already 90 years old this year. It is really admirable that this age group can easily play with actors who are decades younger than him. The key is that his acting skills are still very superb and his mental state is very good. You Benchang’s performance in "Flowers" makes everyone feel reliable and assured. His sincerity has made him gain a good audience.

Recently, the CCTV Spring Festival Gala rehearsal when the media filmed Xin Zhilei appeared in the CCTV building, it is reported that she is the first time to participate in the CCTV Spring Festival Gala, I do not know what she will perform at that time?

Xin Zhilei made her debut at the age of 25 and has starred in many hit TV series since then. Although the series was popular, it did not stir up any splashes for her. Xin Zhilei starred in the role of Li Li in "Flowers", and director Wong Kar-wai portrayed her as both advanced and mysterious. Her retro warm red lips and clothes made her exude a strong feminine smell.

In recent days, there have been many topics about her on the Internet, which can be said to have earned enough attention. Even though Xin Zhilei is a supporting role, she is the actor who has received the most traffic dividends from this drama and has become one of the top performers worthy of the name. It has to be admitted that Xin Zhilei has finally met a good director, a good script and a suitable role for her. Of course, this also requires the right time and place, and you must be careful enough to accumulate your acting skills and wait patiently for the opportunity to appear.

The CCTV Spring Festival Gala stage attracts much attention every year, and it is also a dream place for celebrities. The CCTV Spring Festival Gala program has a high reputation for ratings, allowing people all over the country to see your performance. Maybe, take this opportunity to leave a deep impression on the audience and bring more influence and commercial value to their future development. Being on the CCTV Spring Festival Gala stage also proves that the stars are recognized for their strength and enhance their position in the entertainment industry. Therefore, the stars participating in the CCTV Spring Festival Gala will try their best to get close to the audience.

Today, the film Hot Search, directed by Xin Yukun and starring Zhou Dongyu, Song Yang and Justin, was officially released, which was the first to open the curtain of the year-end Lunar New Year file. In the previous premieres and roadshows, the passion of fighting against the powerful and voicing for the weak in the film directly hit people’s hearts, and the film’s delicate portrayal of the realistic details also gained a lot of praise. Some viewers bluntly said that the film was "pleasantly surprised and moved" and "from God’s perspective, I saw the whole process of public opinion reversal, and director Xin Yukun told a story worthy of everyone’s deep thinking". Xin Yukun, the director, said frankly, "I hope we can see the complexity behind online public opinion and bring the power of this kind voice to everyone.".

At the same time, the film also released a set of posters behind the hot spots. Behind the constantly reversed hot topics, there is a confrontation and game between rescuers and abusers, while the victims are surrounded by topic entries like "warning lines". A "network public opinion war" for justice is about to start.

Aspect 1:

Xin Yukun sharply portrayed the "network public opinion field"

Audience: A comment can save lives or kill people.

"This is an era in which comments can save people and kill people." The film Hot Search focuses on the complex network environment and shows a fierce and realistic "network public opinion war". Faced with the "industrial chain of choosing concubines on campus" involved by the girl’s online rampage, wealthy businessmen tried to cover up the truth and reverse black and white, and how the weak used the power of public opinion to launch a counterattack. A contest between good and evil about justice became more and more fierce. In the film, the plot of "public opinion confrontation" also made the audience feel fresh and wonderful. "The conscience choice from the media, the ups and downs of the Internet, the public’s emotions influenced by public opinion, the goodness and ugliness of human nature … all these are presented one by one in the fast-paced and skillful deep expression".

Aspect 2:

Expose the "interest chain of choosing a concubine" that sends a girl from a desk to a wine table.

Audience: Pointing at reality, shocking.

In the film, a group of self-media people voiced the sexually assaulted girls, and the "campus interest chain" revealed behind the truth also made many viewers bluntly "shocking". Under the banner of charity, wealthy businessmen actually sent girls from desks to wine tables, turning public welfare schools into their own "paradise for choosing concubines". After watching the movie, many viewers said that the relevant plot of the movie reminded people of many similar real events and called "The movie shines into reality". Some viewers said, "The realistic theme is crazy again. The vitality and daring of this film is not in the visual sense, but bloody tears open some illusions, allowing you to face the most real social situation."

Aspect 3:

Zhou Dongyu plays an "imperfect rescuer" to speak for the weak.

Song Yang Justin’s role is full of viewers sighing "what a surprise"

This time, Zhou Dongyu changed her old screen image and played an "imperfect rescuer", with a sharp side and a soft side, which was commented by the audience. "The good is not pure, and the evil is not pure. The dark side and the bright side make her a three-dimensional character." Song Yang and Justin also broke the comfort zone in the past and boldly challenged the new role boundaries. Song Yang plays a "middle-aged social animal" trapped by interests in the film, and the complexity of human nature is vividly displayed in him. Yuan Hong blessed devil wears prada, who played an evil role in the end with gold-rimmed glasses, and did whatever he wanted with power. His wonderful interpretation of the villain also received a lot of hot comments, which was "too annoying".

Aspect 4:

Complex human nature is intriguing, and hidden details are everywhere.

Audience: It’s worth two brushes to savor.

After the premiere and the road show, the delicate and complicated group images in the film also aroused the audience’s strong realistic resonance. The "self-media squad" who speaks for justice all the way, the victim girl who helps each other, the principal who does evil in the name of good, the mother who gives in to reality, and the secretary who becomes an accomplice from the victim ….. Each character in the film reflects different aspects of human nature, which is thought-provoking. The various details hidden in the film also attracted a lot of discussion after the screening, such as the metaphor of coffee, the mirror setting of the relationship between characters, the music played in the office, and the appearance of the behind-the-scenes bosses ….. which made many viewers bluntly say that it was "worth pondering".

Aspect 5:

Every time you make a sound, it has a vital force.

Audience: Defending the truth is defending conscience.

At the seminar held before the film, Hot Search also won unanimous praise from experts, such as "being close to reality", "showing network power" and "calling for rational voice". In an era when online public opinion can be either a dagger or a sword, everyone is prone to get caught up in the whirlpool of public opinion and lose their direction. Some viewers also said with their hearts, "Thanks for the movie ‘ Darkness ’ Exposed to ‘ Sunshine ’ Next, take us to see the whole picture of the online world, and also take us to find the direction of justice. " Self-media people who speak out for justice in movies have also constantly brought strength to everyone, igniting the passion of the audience to speak out for justice. "Defending the truth means defending conscience, and even weak resistance will condense into a storm."

The film "Hot Search" is produced by iQiyi Film (Beijing) Co., Ltd., Beijing Polymerization Film Culture Media Co., Ltd., Oriental Meizhi (Beijing) Film Co., Ltd., Huaxia Film Distribution Co., Ltd., Zhongming Shengshi (Shenzhen) Film Group Co., Ltd. and Phoenix Legend Film Co., Ltd., Beijing Baina Qiancheng Film Co., Ltd., Zhongjing E-sports Entertainment Co., Ltd., Wushuang (Shenzhen) Film Co., Ltd., Junze Film (Ltd. Oriental Meizhi (Beijing) Film Co., Ltd., Beijing Juyinglian Culture Media Co., Ltd. and Iqiyi Film (Beijing) Co., Ltd. issued, Huaxia Film Distribution Co., Ltd. and Shanghai Taobao Film Film and Television Culture Co., Ltd. jointly issued, and the film is being shown.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."