全国凤凰楼信息网

　　21st century business herald reporter Ji Yuanyuan reports from Shanghai Recently, Yixinhe Pharmaceutical Technology Co., Ltd. (hereinafter referred to as "Yixinhe Medicine") developed and produced, and (1) Shakuba Quvalsartan Sodium Tablets (brand name: Yixintan) which was exclusively commercialized was approved by National Medical Products Administration (NMPA). Yixintan is the first generic drug of shakubatravalsartan sodium tablets approved for marketing in the global regulatory market by breaking through the original research patent through innovative crystal forms. The approved indications of this product are for treating essential hypertension and adult patients with chronic heart failure (NYHA II-IV grade, LVEF≤40%) with reduced ejection fraction, so as to reduce the risk of cardiovascular death and hospitalization for heart failure.

　　Immediately afterwards, Unacon also announced that its subsidiary company Shiyao Ouyi developed Shakubatrivalsartan sodium tablets (50mg, 100mg, 200mg) which have obtained the drug registration approval issued by National Medical Products Administration, and regarded them as the adult patients with chronic heart failure (NYHA II-IV grade, LVEF≤40%) with reduced ejection fraction, which reduced the risk of cardiovascular death and hospitalization for heart failure.

　　With the approval of domestic shakubatravalsartan sodium tablets, Novartis, the original drug manufacturer, also released information at the first time, saying that the marketing license for the generic drug of Novartis’ original research product shakubatravalsartan sodium tablets was approved, and Novartis declared that the pharmaceutical active ingredient of the original research product Noxintuo was protected by patents ZL200680001733.0 and ZL201210191052.2 in China.

　　According to the relevant provisions of Article 11 of China’s Patent Law, any enterprise or individual shall not manufacture, use, promise to sell (including applying for online registration, participating in bidding, etc.), sell or import products falling within the scope of the above patent protection before the expiration of the above patent period, otherwise it will constitute patent infringement. To this end, Novartis emphasizes that it will reserve the right to claim its patent right against infringing imitations from relevant judicial and/or administrative organs.

　　Regarding the patent issue, according to the public information, in April 2017, the patent of Shakubatroxobin Sodium Tablets registered by Novartis was declared invalid in China. On July 2, 2021, the crystal patent was also partially invalidated in China. Yixin and Medicine also emphasized in the official disclosure information that in 2022, the domestic sales of Shakuba Quvalsartan sodium tablets totaled nearly 3 billion yuan, and its China patent will expire in November 2026. Yixintan is a first-line drug for the treatment of heart failure and hypertension with independent intellectual property rights, which can legally make the majority of patients with heart failure and hypertension in China use equivalent and affordable innovative drugs three years in advance.

　　It can also be seen that the domestic Shakubatroxobin Valsartan sodium tablets have been approved one after another, which will bring certain market challenges to the original drug.

　　More than 10 pharmaceutical companies compete for the market

　　Shakubatroxobin and valsartan sodium tablets are a new type of eutectic drug composed of enkephalinase inhibitors Shakubatroxobin and angiotensin receptor blocker valsartan sodium tablets in a molar ratio of 1:1. Eutectic structure can make the absorption and elimination rates of shakubarb and valsartan sodium tablets similar, and ensure the synchronous consistency of their efficacy. In addition, compared with independent preparations, eutectic drugs have the advantages of constant composition ratio, good storage stability, and can significantly improve drug solubility and oral bioavailability.

　　As a representative drug of ARNi, Shakubatroxobin sodium tablets have been unanimously recommended by domestic and foreign guidelines in recent years. In 2021, the American Heart Association proposed that ARNi drugs should be given priority to patients with HErEF, and it is recommended to use them to the maximum tolerated dose or target dose (Class I). In 2018, China Heart Failure and Treatment Guidelines also recommended to replace ACEI/ARB with ARNi to further reduce the incidence and mortality of heart failure (Class I).

　　Sakubatravalsartan sodium was originally researched by Novartis Entresto, and was first approved by the FDA in July 2015. It is the world’s first breakthrough and innovative drug in the field of heart failure treatment, and was approved to enter the domestic market for the first time in July 2017. It was included in the national medical insurance category B catalogue through negotiation in 2019, successfully renewed in 2021, and added indications for essential hypertension. In 2021, the global sales of the original research sand kubatroxobin sodium reached US$ 3.548 billion. In 2022, its global sales scale reached US$ 4.644 billion, up 37% year-on-year. In the first half of 2023, the drug also grew into the best-selling drug of Novartis, with sales reaching US$ 2.915 billion, up 31% year-on-year, and it is expected to exceed US$ 6 billion in the whole year.

　　In the China market, the original yanshakubatravalsartan sodium is also a heavy variety. According to the data of the Minenet, the sales growth rate of this product in China’s three major terminals and six major markets has reached triple digits in recent years. In 2021, it exceeded 2 billion yuan for the first time, up 127.62% year-on-year, with full market potential; In 2022, the sales of Shakubatroxobin Sodium Tablets in China’s three major terminals and six major markets exceeded 2 billion yuan. Among them, the hospital market (public hospital terminal+public primary medical terminal) is the main sales channel, with a year-on-year increase of 6.54%.

　　In this regard, some brokerage analysts told 21st century business herald that the innovative product layout must be aimed at chronic diseases, major diseases, diseases that pose a major threat to people’s health, such as cardiovascular diseases, tumors and major infectious diseases. At the same time, the core of making medicine is clinical value. With the rapid development of life science, many interdisciplinary fields are very active, and the large-scale treatment methods focusing on large populations are worthy of attention.

　　"The successive approval of domestic shakubatravalsartan sodium tablets is a great benefit for cardiovascular patients, although the layout of many domestic pharmaceutical companies is already in the clinical stage, except for the single-minded and pharmaceutical/Fosun Pharma, Shiyan Ouyi, including Sichuan Kelun, Chengdu Beite, Qilu Pharmaceutical, Zhengda Tianqing, etc. are also accelerating the layout. This is due to the accelerated layout of many domestic pharmaceutical companies, and the prices of related products are expected to be further lowered, eventually benefiting more patients. " The above analyst said.

　　According to the data of Minenet, at present, there are three companies that have production approval documents for Shakuba Quvalsartan Sodium Tablets. Among them, Unacon Ouyi Pharmaceutical Co., Ltd. and Nanjing Yixin and Medical Science and Technology Co., Ltd. were all approved on the same day with four types of imitation, which are regarded as over-evaluation, and tied for the first imitation and the first over-evaluation. In addition, 17 enterprises, including Shandong New Times Pharmaceutical, Nanjing Zhengda Tianqing Pharmaceutical and Qilu Pharmaceutical (Hainan), all reported their production under the new classification.

　　An unavoidable patent dispute

　　The competitive anxiety between Chinese and foreign pharmaceutical companies in Shakuba Quvalsartan sodium tablets is also considered to be an important reason for patent confrontation. At the same time, in recent years, patent disputes between original drugs and generic drugs have occurred from time to time. 21st century business herald reporter found through the search of Wisdom Bud database that as of the latest, there are more than 700 drug patents with litigation results in China, and more than 99% of them are invention patents. It can be seen that the handling of drug patent disputes needs urgent attention.

　　Yixinhe Medicine also emphasized in the official information disclosure that Yixintan is a first-line drug for the treatment of heart failure and hypertension with independent intellectual property rights. Compared with the reference crystal form, when the relative humidity changes from 20% to 60%, it absorbs less water and is more stable, and can be sealed and stored below 30℃. This stable crystal form is more suitable for the vast China market.

　　When talking about patents, some pharmaceutical executives also told 21st century business herald that the research and development of original innovative drugs has always been a "three high" industry with high threshold, high risk and high return. According to the latest literature, it takes an average of 12.5 years for a new drug to go on the market, which costs nearly $2.6 billion, and the success rate is less than 10%. Every new drug project is the most important decision of an enterprise, and the project process needs a lot of data research, especially the research on patents, documents and regulations takes a lot of time.

　　"Therefore, how to find a balance between ensuring the innovation enthusiasm of the original drug research enterprises and reducing the burden on patients has been hotly debated. The FDA’s definition of generic drugs is very strict, and the requirements must be consistent with the dosage form, specifications and administration route of the copied products. If it is inconsistent, it will be declared as a new drug. " The above-mentioned pharmaceutical company executives said that for the long-term public interest, the state needs to protect the enthusiasm of the original drug research and development enterprises. At the same time, in order to limit the original drug research and development enterprises, it is necessary to encourage the imitation research and development of the original drug from the level of institutional norms and ensure the interests of generic drug enterprises.

　　In order to better balance the interests of the original research drug and generic drug companies with the system, the new Patent Law, which came into effect on June 1, 2021, established the drug patent linking system in China, aiming at linking the two legal procedures, so as to clarify the interest relationship between the original research drug manufacturers and generic drug manufacturers and avoid the problem of patent punishment when the generic drug research and development is completed.

　　As for how enterprises can avoid patent risks, Hou Xuchao, the founding partner of CIC Consulting, also told 21st century business herald that from the perspective of investment and financing, pharmaceutical companies have five key parameters when choosing product pipelines, including the success rate of products under research, patient base, product penetration rate, product pricing and patent life. With the improvement of pharmaceutical companies’ R&D strength, patent life needs more and more attention.

　　"For the patent situation of unlisted drugs, investors need to hire professional IP lawyers to conduct detailed investigations. Because patent conflicts will directly make it difficult for candidate drugs to be marketed, and even directly affect the product value measured by all the above parameters, it is an essential step for patent investigation. " Hou xuchao said.

　　There is a huge crowd in the chronic disease market behind Shakuba Quvalsartan sodium tablets. In terms of hypertension alone, China, as a big country with hypertension, has 245 million adult hypertensive patients, which means that Shakuba Quvalsartan sodium tablets have a broad market space and are an important direction for the future development of drugs. I believe many domestic and foreign manufacturers will make layouts and list related products one after another.

　　However, it should also be noted that after the appearance of the first imitation drug, the clinical data, approval time and product price of the follow-up drugs and enterprises will all be factors affecting the competition pattern, especially the clinical effectiveness and safety, which will be the key to decide who can go further in this track.

Piano robot Special Olympics is playing and singing.

The painting of Microsoft robot "Xiao Bing"

"Xiao Bing" solo exhibition held in Central Academy of Fine Arts

Participants in the "to be no.1" game at the World Artificial Intelligence Conference.

The audience participated in the live interaction of Li Yuansu’s AI work "Nanjing West Road Style Migration"

　　Yangcheng Evening News reporter Jing He

　　"Humans can’t be controlled by artificial intelligence, because humans can’t create smarter creatures than humans." Ma Yun said.

　　"I disagree with you very much. We can create something smarter than human beings, but not necessarily people." Musk said.

　　On August 29th, at the opening ceremony of the 2019 World Artificial Intelligence Conference in Shanghai, Ma Yun and Tesla CEO elon musk had a tit-for-tat "quarrel".

　　Regardless of whether artificial intelligence is smarter than human beings, it is an undeniable fact that AI is infiltrating into every corner of human life, even including the field of artistic creation that was once regarded as exclusive to human beings. If the cooperation between artists and AI only creates a new means of expression, but AI itself learns to create art, which opens the door to a new world.

　　What does AI’s participation mean for creative and imaginative humanistic artistic creation? How should we define "art" today? Is it possible for everyone to become an artist in the future? Artists who are at the forefront of the trend have given us their own answers.

　　1 Smart conference live experience: somatosensory remote control and AR "crossing" are human-computer interaction.

　　Walk into the IBM exhibition area of the 2019 World Artificial Intelligence Conference and raise your hands above your head to make a gesture of love. With the countdown to 54321 over, you will successfully activate an astronaut named CIMON to "land on the moon". On the screen, the astronaut will follow some of your body movements to "swing" his body — — He is representing you "landing on the moon". You can also download photos of yourself "landing on the moon" and post them on social platforms. This CIMON is the first "AI astronaut" launched by IBM. It helped man land on the moon for the first time 40 years ago.

　　In the "to be no.1" exhibition area where Shangtang Technology cooperates with the Forbidden City, as long as you make a gesture, you can "cross" to take a photo with Confucius in ancient times, and you can also use face recognition technology to "transform" into a scholar who is in Beijing to take an exam and take an ancient imperial examination.

　　The artwork "Nanjing West Road Style Migration" created by young painter Li Yuansu using AI technology is also a popular interactive project in the exhibition hall. When the audience enters the exhibition area, the camera will capture the corresponding pictures, which are processed by human detection, background segmentation, human-computer interaction and other technologies, and then the computer will combine the study of the painter’s past works and make real-time creation. On the display screen, the audience can see their own figure and become a stylized image in real time. Although these works are only based on the creation of man-machine cooperation, it is undeniable that AI has penetrated into all aspects of human life.

　　2 Interaction triggers reverse trigger: artists begin to think about "how to express intelligent objects"

　　In fact, in the AI era, the integration of human artistic creativity and AI has become a "new trend", and there have been many interactions between them.

　　In 2017, Google launched Autodraw, a tool that can help people draw stick figures. With just a few strokes, the algorithm can identify what you want to draw and optimize it for you. In 2018, the digital creation studio OUCHHH launched an exhibition named "Poetic AI" at the Paris Art Center, France. By learning the articles of scientists who have changed human history, AI transcoded them into words and images, and then projected them into a space of 3,300 square meters through 136 projectors. The effects of light and motion are also automatically generated through preset algorithms, which can provide an immersive experience combining sound, light and shadow for the audience. Also in 2018, at Christie’s auction, the painting "The Portrait of Edmund Bellamy" created by AI was taken at a price of 432,500 US dollars (about 3.01 million yuan).

　　Interestingly, Li Yuansu pointed out a new phenomenon: artists used to like to express figures, flowers, birds and mountains. When AI appeared, some people began to think about "how to express intelligent objects". "In the past, artists may describe the sparkling water, but what excites contemporary artists may be the flashing LED lights and the computing interface of supercomputers." He believes that "these are the reverse triggers of artificial intelligence on artistic creation inspiration."

　　3 Constantly unlocking new skills: Microsoft Xiao Bing, who can write poetry and sing, also learned to draw.

　　In May 2014, Xiao Bing, an intelligent chat robot launched by Microsoft (Asia) Internet Engineering Institute, was born. This is a girl who pays attention to EQ and takes an emotional route. In the past five years, Microsoft Xiao Bing has been unlocking new skills. She published a collection of poems, learned to sing, can host programs, and learned to draw as an "supernumerary" graduate student of the Central Academy of Fine Arts. At the World Artificial Intelligence Conference, Xiao Bing’s paintings attracted many audiences with unique style.

　　The painter Xiao Bing’s debut time is not long, but he has become a minor celebrity. In May this year, Microsoft Xiao Bing, under the pseudonym of "Xia Yubing", exhibited her works for the first time at the 2019 Graduate Exhibition of Central Academy of Fine Arts, and became an "supernumerary" master graduate of Central America.

　　After graduation, Microsoft Xiao Bing is "non-stop". From June 15th to July 15th this year, the cross-border exhibition of contemporary art "Xiao Bing, Painting for a Period" was held in Liangzhu Culture and Art Center, Hangzhou, featuring paintings created exclusively by Xiao Bing and VR immersive works created interactively by new media artists Zhou Linwei and Xiao Bing. Later, Xiao Bing’s first solo exhibition "Possibility World" was held in the Art Museum of the Central Academy of Fine Arts.

　　Now just go to Xiao Bing’s homepage and enter a simple text on the page to activate her, and you can entrust Xiao Bing to make a painting for you. After extracting intention, stimulating creative inspiration, selecting content theme, trying to compose the picture, drafting line drawing modeling, painting the bottom color, deepening the picture level and polishing the details repeatedly, the painting created by Xiao Bing can be released in three minutes.

　　According to the Microsoft Xiao Bing team, Xiao Bing spent 22 months studying the paintings of 236 famous painters in the history of art. When inspired by texts or other creative sources, Xiao Bing can independently complete 100% original paintings. This originality is not only reflected in composition, but also in color, expressiveness and details. Li Di, the head of Xiao Bing’s team, stressed: "Xiao Bing’s painting ability is not based on filters and migration technology — — That is, search the picture of the corresponding theme from the landscape library, and then use the oil painting filter to process it. " He said that painting model is the third kind of AI model after text and pronunciation, and it is also the longest and hardest project.

　　Qiu Zhijie, Dean of Experimental Art College of Central Academy of Fine Arts, spoke highly of Xiao Bing’s works. "Xiao Bing’s works are diverse in style, skillful in technique, fast in painting and large in quantity, from which we can find many good paintings." Qiu Zhijie said, "We set several aesthetic rules for artificial intelligence, and it will use these rules to combine endless changes. If you set it to ‘ Do not repeat ’ The instructions, AI actually has a greater chance to get rid of the routine. "

　　Xiao Bing is developing towards the route of piano, chess, calligraphy and painting, which makes her look more like a "person". In May 2017, Xiao Bing’s original poetry collection "Sunshine Lost Glass Window" was published, which is the first poetry collection created entirely by AI in human history. This year, Xiao Bing and the poet’s poetry collection "Flowers are Silence of Green Water" came out, which is also the result of writing poems jointly by man and machine. About 200 poems were finally selected from 6,000 submissions.

　　However, whether it is poetry or painting, Xiao Bing’s works still clearly bear traces of AI. For example, there is a lack of effective transition between poetic images, irrationality between logics, and inconspicuous poetry, etc. Although Xiao Bing’s team said that Xiao Bing’s paintings are close to human level, the audience can still see with the naked eye that Xiao Bing’s works have no three-dimensional sense of oil painting, appear more flat, and can’t see the lines of a painting.

　　4 human beings are hard to be replaced: AI singers who lack emotion are hard to impress people.

　　On the evening of August 29th, when the virtual singer Tianyi Luo’s singing sounded in the Shanghai Benz Cultural Center, the familiar Jasmine seems to be a little strange. As the most famous virtual singer in China, Tianyi Luo has held ten thousand people’s holographic concerts for three years in a row, creating a precedent of "domestic virtual singer AR live broadcast on a large variety show".

　　Then came the piano robot Special Olympics from Italy. I saw his 53 fingers dancing on the keys quickly and accurately, playing and singing Perfect by British singer ed sheeran, Special Olympics’ hard-core head and unique singing voice, leaving a different memory for the audience.

　　At the first audio-visual feast of AI and art in China, AI brought us into a brand-new art world. Man-machine interaction, motion capture, virtual reality, holographic images, three-dimensional images and other technical means are combined with music, dance, opera and other artistic forms to jointly create a mirror world of light and shadow, and a visual spectacle of illusion.

　　However, when you listen carefully, the songs of Tianyi Luo and Special Olympics are still a little less natural and agile. Although the ups and downs of the vocal range can be realized by AI, the free flow and emotional expression of human voices can never appear on AI robots.

　　Artificial intelligence has greatly broadened the boundaries of art and made machines more like people. But "0" and "1" can’t teach machines to have unique human emotions. Without the artistic expression of emotion, it is difficult to really hit the hearts of the audience, and of course, it also makes people realize the "irreplaceable" of human voice.

　　On the Zhihu, someone asked: "What is the significance of developing AI production art?" Xiao Yao, the author of the science fiction "AI Trek", replied: "Artists will not disappear. AI will only eliminate some guys who are not innovative, and those who are truly capable and talented will only get better and better. If the artist’s creative enthusiasm will be hit by AI, it only means that it is normal for these guys to be eliminated. It’s like the appearance of a car is bound to hit ‘ Camel Xiangzi ’ Children, and part of ‘ Camel Xiangzi ’ I learned a driver’s license and became a taxi driver. "

　　interlinkage

　　Dialogue with Li Yuansu — —

　　Art still needs to return to the level of humanity and flesh.

　　Yangcheng Evening News: When did you start using AI for artistic creation? Are you satisfied with the results of this creation?

　　Li Yuansu: This is the first time I have combined with AI to create. With the theme of artificial intelligence, each of the three works has a clear experimental purpose: the mural of "AI Hegemony" is a struggle between hand painting and digital printing on the old media of "mural"; The game "AI Hegemony" uses the same material as murals, and the form is the game interaction mode in the "pre-AI era"; "Nanjing West Road Style Migration" uses contemporary cutting-edge AI technology. In this work, AI learns the artistic style independently and makes his own real-time creation. The three works show the aesthetic characteristics of different media from manual to digital, from static to interactive. The final result is to meet the expectations.

　　Yangcheng Evening News: What new possibilities does AI offer for artistic creation?

　　Li Yuansu: If we sum up the traditional appreciation of art as a group of relationships between artists and audiences, then this group of relationships in the AI era will be expanded, and we will have various combinations such as "machine creation-audience watching", "artist creation-machine watching" and "machine creation-machine watching". Of course, it is not easy to discuss whether machines can produce emotions and how to define emotions, but it is my purpose to do these works to explore along these lines.

　　Yangcheng Evening News: What do you think of the future artistic creation trend?

　　Li Yuansu: Now it seems that the role of artificial intelligence technology in human art will not be subversive. The role of AI in human art is expansion. It brings unprecedented media relations, creative materials, inspiration and great help. It allows human beings to better understand themselves in the mirror of science and technology. However, for the "machine art", recent years may only be the time when it originated.

　　Yangcheng Evening News: When artistic installations can continuously create works without the participation of artists, how should we treat these works of art? Is the painting made by artificial intelligence a real work of art?

　　Li Yuansu: The relationship between art and audience is consensual, and art is a condensed form of emotional experience. So, as long as someone is willing to admit that it is a work of art, it is. This is in essence. However, whether it is recognized academically or accepted by the art market will definitely lead to different situations and twists and turns.

　　Yangcheng Evening News: Is the essence of science and technology art art or technology? Will future artists be replaced by creative artificial intelligence machines?

　　Li Yuansu: Science and technology art is still art. In fact, today’s art is also inseparable from "technology". For example, canvas is a textile technology, and pigments need mineral and chemical technology, including photography and video, which were once high-tech — — Humans will always take everything at hand to create art and "play" art.

　　Artistic creation will not be replaced by machines. For creators, the first thing in art is to serve themselves, and it is an act of expressing emotions and recording experiences. In the contemporary era when information technology subverts the way of life, we are still trapped in the warmth of manual work. At present, only by returning to the level of humanity and flesh can the new media art gain the recognition of more audiences, and the pure aesthetics of science and technology is cold to most people.

In recent years, reports about "superbug" are common. It is no longer just the concern of medical workers, but has become a global problem.

"Superbacteria" actually does not refer to a specific bacteria, but generally refers to those bacteria that show resistance to at least three kinds of commonly used antibacterial drugs in clinic. Its academic name is "multi-drug-resistant bacteria".

In the face of "superbugs", only by understanding their characteristics and transmission mechanism can we better slow down their production and curb their spread.

"past lives" of Multi-drug Resistant Bacteria

Penicillin was discovered by alexander fleming in 1928. This powerful "sharp weapon" for treating bacterial infections saved countless lives in World War II. However, with the widespread use of penicillin and other antibacterial drugs, the first superbug in history-methicillin-resistant Staphylococcus aureus appeared, and then more and more superbugs appeared.

According to the report of China Bacterial Resistance Monitoring Network, the main clinical problem in China is Gram-negative bacilli which are resistant to carbapenems. The data in the first half of 2023 showed that the resistance rate of Acinetobacter baumannii to carbapenems was as high as 79.5%. These shocking data highlighted the seriousness of bacterial resistance in China.

In 2022, the authoritative medical magazine The Lancet published a survey of 204 countries and regions around the world in 2019. The study showed that antimicrobial resistance directly led to more than 1 million deaths, which even exceeded the number of people killed by malaria or HIV infection; The number of indirect deaths is even more alarming: nearly 5 million people. In 2016, the global research report on drug-resistant bacteria infection commissioned by the British government showed that by 2050, nearly 10 million people will lose their lives every year due to antimicrobial resistance.

Dr Margaret Chan, former Director-General of the World Health Organization, once pointed out that with the increasing and spreading of multidrug-resistant bacteria, common infection may once again become a fatal threat. This is not an alarmist. When human beings encounter the dilemma of no medicine available, even trivial wounds or respiratory infections may easily take their lives, and human beings will undoubtedly return to the dark period before the discovery of penicillin.

Why do drugs "fail" to bacteria?

Drug resistance of bacteria refers to the tolerance of bacteria to antibacterial drugs, which can be divided into congenital drug resistance and acquired drug resistance. Congenital drug resistance refers to the innate tolerance of bacteria to certain antibacterial drugs, which can be passed down from generation to generation; Acquired drug resistance means that bacteria "acquire" drug resistance genes due to spontaneous gene mutation or from other drug-resistant bacteria. Drug-resistant bacteria usually refer to acquired drug-resistant bacteria.

Drug resistance of bacteria is actually the result of natural selection in the process of evolution. In the process of its growth and reproduction, the reasons for promoting drug resistance involve many aspects, such as gene mutation or variation of bacteria, improper use of drugs and decreased immunity of the body, which may be the potential reasons for drug resistance.

The abuse of antibacterial drugs is an important factor leading to bacterial drug resistance. "Abuse" is mainly manifested in two aspects: unreasonable use in the treatment of human diseases and excessive and improper use in animal husbandry. Due to the selection pressure of antimicrobial agents, those bacteria with drug resistance will be naturally selected and multiply, thus accelerating the reproduction and spread of drug-resistant bacteria.

Multi-drug-resistant bacteria are mainly transmitted through contact, such as blood, sputum, urine or secretions of patients carrying multi-drug-resistant bacteria; Or contact with equipment, fabrics and pools contaminated by multi-drug resistant bacteria; For respiratory tract infection or colonization of multidrug-resistant bacteria can also be spread through droplets.

Antibacterials that have been "misunderstood"

The public’s understanding of antibacterial drugs is relatively limited, which leads to drug abuse becoming a common problem. There are 10 common misunderstandings in the use of antibacterial drugs, which need to be corrected as soon as possible:

1. Antibacterials are omnipotent anti-inflammatory drugs;

2. Do not distinguish the causes of colds, and use antibacterial drugs;

3. Antibacterials are the first choice for fever;

4. Diarrhea is inflammation, and it is best to use antibacterial drugs;

5. Broad-spectrum antibacterial drugs have stronger antibacterial ability, and the therapeutic effect is often better than narrow-spectrum antibacterial drugs for specific pathogens;

6. Newly listed and expensive antibacterial drugs are preferred;

7. The combination of multiple antimicrobial agents can effectively control infection;

8. It doesn’t matter if antibacterial drugs are frequently replaced;

9. Self-preventive use of antibacterial drugs during the high incidence of respiratory diseases in winter and spring.

10. The medication is not standardized, not enough, and the medication will be stopped if the symptoms improve slightly.

Abuse of antibacterial drugs will not only lead to bacterial resistance, but also lead to a series of serious adverse reactions, among which allergic reactions are particularly common, such as itchy skin, rash and other symptoms, and even life-threatening conditions such as anaphylactic shock may occur in severe cases; Some drugs may also cause nervous system symptoms, such as headache and dizziness. Some antibacterial drugs can also have toxic effects on hearing and kidneys; Abuse of antibacterial drugs will destroy the balance of flora in the body, which will cause a large number of inhibited bacteria to multiply and cause double infection.

Standardize drug use and prevent drug resistance

Remember 7 points.

1. Don’t buy drugs at will: Most antibacterial drugs belong to the category of prescription drugs. You must issue a doctor’s prescription when buying them, and you can’t buy them online or in a physical pharmacy at will.

2. Don’t choose your own medicine: When choosing which kind of antibacterial drugs to use, it should be judged by professional doctors according to the condition and clinical test results, not just by advertising or personal experience.

3. Do not use drugs at will: When using antibacterial drugs, we should follow the doctor’s advice to ensure that they are taken after professional diagnosis in the hospital, and do not blindly abuse drugs, especially for some daily ailments (such as colds), it is not appropriate to use antibacterial drugs easily.

4. Do not stop taking drugs without authorization: Once you use antibacterial drugs, you must follow the doctor’s instructions and take the drugs on time, according to the dosage and according to the course of treatment.

5. Pay attention to personal hygiene: frequent hand washing, more ventilation and avoiding close contact with patients are helpful to prevent infection.

6. Strengthen exercise: enhance physical fitness and immunity, and reduce the use of antibacterial drugs from the source.

7. Don’t throw drugs at will: expired drugs belong to harmful waste, so they should be thrown into the hazardous trash can to prevent criminals from recycling them. Garbage sorting, protect yourself and others.

The doctor concluded:

The increasingly serious problem of drug-resistant bacteria has become a major challenge in the field of global public health, which is attracting widespread attention from the medical community, government and society. In daily life, we should pay attention to developing healthy living habits, ensuring clean diet, actively exercising to enhance our immunity, and at the same time, we should follow scientific principles and standardize the use of antibacterial drugs. The whole society needs Qi Xin to work together to slow down the emergence of drug-resistant bacteria and curb its spread.

Text | Shen Chunmei

Deputy Chief Technician, Department of Hospital Sense, Fifth People’s Hospital Affiliated to Fudan University

Editor | Wang Jingming

Audit | Ye Haixia

Producer | Li Wenjing

Medical Support | Shanghai Medical Association Science Popularization Branch

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Online celebrity Li Yutong was exposed by Joker Xue for cheating money and feelings.

1905 movie network news On the evening of September 12th, Li Yutong, online celebrity, published a document in Weibo, revealing that Joker Xue had cheated money and feelings, and had paid a breakup fee of 10 million with Xue. Li Yutong wrote in Weibo that in 2012, they jointly opened a Taobao shop called "UUJULY", which was a pure partner, but suddenly one day Xue confessed to me that he had fallen in love with me deeply. But I can’t be with this man.

Online celebrity said that the two had cooperated to open a Taobao shop.

　

A week later, Joker Xue called to say that Gao Leixin had a miscarriage, and the two divorced, but they needed to claim 10 million divorce fees. Xue promised to stay with me after paying back the money, and the two of them would bear the divorce fees together. One day late at night, I got a call from Xue, saying that Gao Leixin had a pituitary tumor and needed another 10 million to see a doctor, otherwise it would be revealed that Xue had abandoned his illness. Li Yutong also said that two years later, I left this vortex, ended this relationship and gave up everything.

　

Online celebrity Weibo said that the news will continue tomorrow.

This matter has caused a heated discussion on the Internet, and netizens have different opinions. Later, Weibo, the official of Extreme Challenge, reprinted Weibo of Li Yutong and wrote: "Hey, I actually knew you were together for a long time." But this morning, Weibo, the official of Extreme Challenge, said: "Statement: it has been found out. At 23: 53 on September 12th, Guanwei forwarded a Weibo for no reason. Actually, the account was stolen, and the password has been urgently changed! I sincerely apologize to you! "

　"Extreme Challenge" officially reprinted online celebrity Weibo

"Extreme Challenge" officially said that it was stolen.

Before the deadline for publication, Joker Xue didn’t respond to this matter. Fans in Joker Xue left a message in Weibo, online celebrity: "I believe Joker Xue is a good man." "Please prove it with a hammer. Where are the pictures of you two together? What about the chat record? " It is really hard to believe that a crowd of spectators can’t figure out their minds in the fog, but only rely on a piece of paper.

　　BEIJING, May 8 (Xinhua) According to the website of the Ministry of Agriculture and Rural Affairs, the Ministry of Agriculture and Rural Affairs and the National Rural Revitalization Bureau recently jointly issued the "Guidelines for Social Capital Investment in Agriculture and Rural Areas (2021)" (hereinafter referred to as the "Guidelines"). Among them, 13 key industries and fields to encourage social capital to invest in agriculture and rural areas have been identified, including modern breeding industry and rural enriching industry.

　　In terms of basic principles, the Guidelines put forward that farmers’ dominant position should be respected. Fully respect farmers’ wishes, give full play to farmers’ main role in rural revitalization, guide social capital to establish a close interest linkage mechanism with farmers, and continuously improve people’s sense of gain. Support social capital to expand business according to laws and regulations, pay attention to win-win cooperation, run more industries that farmers can’t do, can’t do well, and can’t do well, and leave more income in the countryside; Do more industries with long chain, high participation of farmers and wide benefits, and leave more jobs to farmers; Do more industries to consolidate and expand the achievements of tackling poverty and help and lead agriculture, so as to promote the synchronous development of rural areas and the synchronous progress of farmers.

　　Follow the laws of the market. Give full play to the decisive role of the market in resource allocation, better play the role of the government, guide social capital to inject modern production factors such as talents, technology and management into agriculture and rural areas, and accelerate the establishment of modern agricultural industrial systems, production systems and management systems. Adhere to the "streamline administration, delegate power, strengthen regulation and improve services" reform direction, establish and improve the supervision and risk prevention mechanism, create a fair competitive market environment, policy environment and rule of law environment, reduce institutional transaction costs, create good and stable market expectations, and attract social capital to enter key agricultural and rural areas.

　　Insist on pioneering and innovating. Encourage social capital to cooperate with the government and financial institutions, give full play to the advantages of marketization and specialization of social capital, accelerate the innovative application of investment and financing models, open up more effective paths for social capital to invest in agriculture and rural areas, and explore more typical models. Effectively tap the investment potential in rural services, broaden the channels of social capital investment, maintain the steady growth of agricultural and rural investment, foster new kinetic energy for economic development, and enhance the endogenous motivation for economic growth.

　　In terms of key industries and fields to encourage investment, the Guidelines clearly define the objectives and tasks of comprehensively promoting rural revitalization and accelerating agricultural and rural modernization, based on the current new situation and new requirements of agriculture and rural areas, focusing on the key areas and key links of agricultural supply-side structural reform and rural construction, and promoting the transformation and upgrading of agricultural and rural economies.

　　(1) Modern breeding industry. Support social capital to develop large-scale, standardized, branded and green breeding industry, promote variety cultivation, quality improvement, brand building and standardized production, and help improve the supply guarantee capacity of grain and important agricultural products. Consolidate the production of grain, cotton, oil, sugar and gum in the main producing areas, vigorously develop facility agriculture, extend the industrial chain, and increase the supply of green and high-quality products. Encourage social capital to vigorously develop silage corn, high-yield and high-quality alfalfa and other forage production, and develop herbivorous animal husbandry. Support social capital to speed up the construction of a modern breeding system, rationally arrange large-scale farms, stabilize the basic production capacity of pigs, increase investment in deep processing of pigs, accelerate the formation of an industrial layout that matches breeding and slaughter processing, and improve the long-term mechanism for the stable and orderly development of the pig industry; Actively develop cattle and sheep industry and increase the stock of basic female livestock; Steadily promote the development of poultry and other industries and increase the overall supply of meat market. Encourage social capital to build a high-quality milk source base, upgrade and transform small and medium-sized dairy farms, and make the national dairy industry bigger and stronger. Encourage social capital to develop green and healthy aquaculture of aquatic products, carry out intensive, industrialized circulating aquaculture, comprehensive planting and breeding of rice and fishery, large-scale ecological aquaculture, saline-alkali aquaculture and intelligent cage aquaculture in the deep sea, promote the construction of marine pastures and large-scale intelligent aquaculture fishing grounds in the deep sea, and increase investment in offshore fisheries.

　　(2) Modern seed industry. Encourage social capital to invest in innovative seed enterprises, promote the deep integration of scientific and technological enterprises, support leading seed enterprises to improve the commercial breeding system, enhance the innovative ability of commercial breeding, and enhance the international competitiveness of China’s seed industry. Guide social capital to participate in the improvement of independent innovation ability of modern seed industry, strengthen the capacity building of germplasm resources preservation and utilization, breeding innovation, variety testing and demonstration, improved seed breeding, promote the integrated development of breeding, reproduction and promotion, and establish a modern seed industry system. On the basis of respecting science and strict supervision, encourage social capital to actively participate in the industrial application of biological breeding. Innovatively promote the model of "leading enterprises+superior bases", support social capital to participate in the construction of national southern breeding bases, promote the construction and upgrading of national seed production bases in Gansu and Sichuan, and accelerate the construction of large seed production counties and regional breeding bases. Encourage social capital to invest in the construction of livestock and poultry aquatic breeding farms (protected areas), national breeding farms, variety testing stations and livestock and poultry breeding stations to improve the development level of livestock and poultry aquatic seed industry.

　　(3) Rural industries that enrich the people. Encourage social capital to develop characteristic agricultural and rural resources, actively participate in the construction of modern agricultural industrial parks, strong agricultural towns, advantageous characteristic industrial clusters, develop advantageous areas of characteristic agricultural products, and develop green agricultural products, organic agricultural products and geographical indication agricultural products. Develop "one village, one product", "one town, one specialty" and "one county, one industry", build standardized production bases, intensive processing bases, warehousing and logistics bases, improve the scientific and technological support system, production service system, brand and marketing system and quality control system, and establish a construction and operation mechanism with close interests. Develop rural handicrafts with ethnic, cultural and regional characteristics according to local conditions, and develop a number of family factories, manual workshops and rural workshops. Accelerate the cultivation of agricultural brands, strengthen brand marketing and promotion, encourage social capital to support the construction of regional public brands, and create a number of brand products with "local brand name" and "township brand name" and brands of agricultural enterprises with market competitiveness. Support social capital to invest in the construction of standardized rural factories and workshops, and develop rural industries such as specialty food, manufacturing, handicrafts and green building materials.

　　(four) agricultural products processing and circulation industry. Encourage social capital to participate in the development of agricultural products processing industry in major grain producing areas and advantageous areas of characteristic agricultural products, promote the coordinated development of primary processing, intensive processing and comprehensive utilization and processing of by-products, improve the level of mechanization and standardization of the industry, and help build a number of intensive processing bases for agricultural products and strong processing counties. Coordinate the construction of agricultural products producing areas, distribution centers and wholesale markets, and encourage social capital to participate in the construction of national agricultural products producing areas professional markets and farmland markets. Encourage social capital joint family Farm and farmers’ cooperatives to jointly develop the cold chain logistics system for agricultural products storage and preservation, build a number of facilities and equipment such as storage and preservation, graded packaging and cold chain distribution, and build small cold chain storage and preservation facilities in Tiantou, encourage qualified places to build low-temperature direct distribution centers of producing areas, improve the efficiency and quality of cold chain logistics services, build agricultural products logistics nodes, and develop new circulation formats such as agricultural supermarkets, agricultural cooperatives, agricultural enterprises and agricultural schools.

　　(5) New rural service industry. Encourage social capital to develop leisure agriculture, rural tourism, catering and lodging, creative agriculture, farming experience, health care base and other industries, fully tap the advantages of various resources such as agriculture and rural ecology and culture, and create a number of rural leisure tourism destinations with complete facilities, diverse functions and standardized services. Guide social capital to develop cultural industries with rural characteristics, promote the integration of agriculture, business, literature and tourism, tap and utilize agricultural cultural heritage resources, build agricultural theme museums and village history museums, and inherit agricultural handicrafts, folk arts and folk festivals. Support social capital to develop agricultural production custody services, provide social services such as market information, agricultural technology extension, agricultural materials supply, unified prevention and control, subsoiling and land preparation, and agricultural product marketing, build a number of agricultural science and technology service enterprises and service-oriented farmers’ cooperatives, and promote the introduction of advanced and applicable varieties, inputs, technologies and equipment into small farmers. Encourage social capital to transform traditional small businesses, small stores, small markets and other commercial outlets to meet the needs of rural residents’ consumption upgrading, actively develop life service industries such as wholesale and retail, old-age care, culture and education, environmental sanitation, develop online and offline service outlets, promote convenient, refined and quality development, and provide convenient and thoughtful services for rural residents.

　　(6) Ecological circular agriculture. Encourage social capital to actively participate in agricultural and rural emission reduction and carbon sequestration. Support social capital to participate in the pilot project of green planting and recycling agriculture, the resource utilization of livestock manure, the comprehensive utilization of straw, the recycling of agricultural film pesticide packaging, the harmless treatment of sick and dead livestock and poultry, the recycling and reuse of abandoned fishing nets, and increase investment in the collection, storage and transportation and treatment system. Encourage social capital to invest in rural renewable energy development and utilization, increase investment in rural energy comprehensive construction, popularize rural renewable energy utilization technology, and explore new modes of straw bale direct combustion and briquette fuel heating, and biogas bio-natural gas supply and heating. Support social capital to participate in the ecological protection of the Yangtze River and Yellow River basins, the protection of black land in Northeast China, the control of agricultural non-point source pollution, and the remediation of cultivated land polluted by heavy metals.

　　(7) Agricultural scientific and technological innovation. Encourage social capital to establish innovative agricultural science and technology enterprises, participate in tackling key agricultural core technologies, and carry out R&D and innovation, achievement transformation and technical services in the fields of biological seed industry, high-end intelligence and agricultural machinery, fishery equipment, green inputs, environmental protection fishing gear and fishing boats with new materials such as glass fiber reinforced plastic in hilly areas. Encourage social capital to take the lead in the construction of scientific and technological innovation platform bases such as the State Key Laboratory of Agriculture, participate in the construction of agricultural scientific and technological innovation alliance and national modern agricultural industrial scientific and technological innovation center, promote the deep integration of Industry-University-Research, and build a scientific and enterprise integration and innovation consortium. Guide social capital to develop technology trading markets and technology service institutions, provide services for the transformation of scientific and technological achievements, and accelerate the integration, innovation and popularization and application of advanced and practical technologies.

　　(8) Training of agricultural and rural talents. Support social capital to participate in the cultivation of agricultural production and management talents, rural secondary and tertiary industry development talents, rural public service talents, rural governance talents, agricultural and rural scientific and technological talents, rural infrastructure construction and management talents. Encourage social capital to build training bases based on raw material bases and industrial parks, and build rural talent incubation bases based on the advantages of information, technology, brand and capital. Encourage social capital to provide incentives, technical support and management services for outstanding agricultural and rural talents, and promote agricultural and rural talents to stand out.

　　(9) Construction of agricultural and rural infrastructure. Support social capital to participate in high-standard farmland construction, farmland water conservancy construction, rural resource roads, industrial roads, tourist roads and main roads in villages, mechanized transformation of farmland in hilly and mountainous areas, standardized transformation of large-scale water supply projects and small-scale projects, and the construction of rural gas storage stations and micro-pipe network gas supply systems, promote the overall construction of regionalization, promote the comprehensive supporting of roads and electricity in Tian Shuilin, and simultaneously develop efficient water-saving irrigation. Encourage participation in the construction of fishing ports and sheltered anchorage.

　　(10) Construction of smart agriculture. Encourage social capital to participate in the construction of smart agriculture, promote the application of agricultural remote sensing, Internet of Things, 5G, artificial intelligence, blockchain, etc., promote the deep integration of new generation information technology with agricultural production and management, quality and safety control, and improve the level of agricultural production intelligence and management network. Encourage participation in the construction of big data in agriculture and rural areas, the basic data resource system and the construction of big data centers in the whole industrial chain of important agricultural products. Provide information services for new agricultural business entities and small farmers. Encourage participation in the construction of information infrastructure in rural areas and improve the informatization level of rural governance and social and cultural services. Encourage participation in the construction of "internet plus" agricultural products leaving the village and entering the city, promote the online sales of high-quality characteristic agricultural products, and promote the docking of agricultural products production and marketing.

　　(eleven) rural entrepreneurial innovation. Encourage social capital to invest in the construction of platform carriers, such as returning home and entering the countryside pioneer park, rural entrepreneurial innovation park and incubation training base, strengthen the construction of infrastructure and service system of various platform carriers, promote cooperation in Industry-University-Research, and stimulate the vitality of rural entrepreneurial innovation. Encourage social capital to cooperate with ordinary universities, vocational colleges and high-quality education and training institutions to carry out entrepreneurial ability, industrial technology and management training for rural entrepreneurial innovation leaders, and build a collaborative innovation base for Industry-University-Research.

　　(twelve) rural human settlements improvement. Support social capital to participate in the five-year action of rural human settlements improvement. Encourage social capital to participate in the construction and operation of rural toilet revolution, rural domestic waste treatment, rural domestic sewage treatment and other projects, improve the collection, transportation and disposal system of rural domestic waste, and build a number of comprehensive disposal and utilization facilities for organic waste. Encourage social capital to participate in village cleaning and greening actions. Promote the improvement of rural human settlements and the development of rural leisure tourism.

　　(13) Agricultural foreign cooperation. Encourage social capital to participate in overseas agricultural investment cooperation, build state-invested production and processing, warehousing and logistics projects such as grain, cotton, oil, sugar, rubber, livestock and fishery in the "Belt and Road", and build overseas agricultural cooperation parks, which will form a useful supplement to domestic agricultural production; Participate in the export of agricultural services, integrate relevant agricultural production factors, provide problem-oriented integrated solutions, and drive the production capacity of agricultural materials, agricultural machinery, agricultural products processing and other fields to go out; Participate in the construction of high-quality agricultural international trade development bases and agricultural opening-up cooperation pilot zones, innovate agricultural economic and trade cooperation models, connect relevant rules and standards, cultivate export agricultural products brands, build international marketing promotion networks, and cultivate new advantages in agricultural international competition.

　　The "Guidelines" mentioned that the cooperation model between government and social capital should be innovated. Encourage credit and insurance institutions to increase the innovation of financial products and services, cooperate with the financial support for the implementation of major agricultural and rural projects, and increase the exploration of investment and financing modes such as investment and loan linkage and integration of investment, loan and insurance. Actively explore public welfare projects with stable income in the agricultural and rural areas, and promote the implementation path and mechanism of the government and social capital cooperation (PPP) model, so that social capital investment can be expected, rewarded and sustained, and the government and social capital cooperation can be promoted in an orderly and compliant manner. Encourage agricultural and rural departments at all levels to systematically sort out agricultural investment projects in the region in accordance with the requirements of documents related to government and social capital cooperation in the agricultural field, screen and cultivate rural revitalization projects suitable for PPP mode, and give priority to supporting agricultural and rural infrastructure construction and other public welfare projects with certain benefits. Encourage social capital to explore ways such as asset securitization and equity transfer to revitalize the existing assets of the project and enrich the channels for capital to enter and exit.

　　The "Guidelines" require that agricultural and rural departments at all levels should take guiding social capital to invest in agriculture and rural areas as an important task, strengthen communication with departments such as finance, development and reform, finance and natural resources, promote information sharing, and coordinate relevant departments to base themselves on their functions and cooperate closely to form a joint force. It is necessary to establish a standardized cooperation mechanism, guide social capital to actively participate in relevant planning and project sorting, strictly follow the spatial control of "three districts and three lines" in rural planning, accurately grasp the investment direction, actively explore specific ways, improve the landing efficiency of various projects, and give full play to the joint efforts of government, market and social capital. Strengthen the management of foreign investment and promote foreign investment in agriculture and rural areas in accordance with the relevant provisions and requirements of the Foreign Investment Law.

Speaking of it, in the eyes of most consumers, it is an out-and-out family car. Because every update is very suitable for the current car demand, its sales performance is good, and it has left the title of "sales king" in the market. In 2018, its annual sales volume reached 463,000, winning the first place in the passenger car market in China. In the past 2019, its monthly sales volume exceeded 50,000 for many times, making it a car field. However, for me, the status of the king today is not achieved overnight, but has undergone 13 transformations.

13 transmutations in exchange for 14 more mature generations.

The "civilian BMW" developed to the extreme by the 1st-8th generation sports.

In 1959, the first generation was born, but it was not called at that time. It was a 5-seat small passenger car under the name of "BLUEBIRD". It used a 4-cylinder 1.2-liter engine and conquered American consumers with its brisk driving experience. The second to fourth generation Nissan uses deeper technology research and development and better adjustment ability to maximize the performance of cars. The third-generation 1.6L four-speed manual transmission model launched in 1967 officially opened the best-selling road, and its excellent suspension and excellent chassis adjustment were also called "civilian BMW" by fans. The 8th generation, which came out in 1987, has a smoother and lower profile. It is equipped with the famous ATTESA four-wheel drive system, which can provide 1.8L turbocharged power option. On the suspension system, the basic design of front McPherson and rear strut suspension is adopted, and the body weight is optimized. The sports performance can be described as the ultimate development.

9 th -11 th generation technology armed to teeth

The ninth generation and the tenth generation focused on the configuration of science and technology. At the turn of the century, the ninth generation achieved great success with the "E" configuration as its selling point. At that time, the car was equipped with mobile hands-free phone, intelligent rearview mirror and HUD, which could project the speed on the corner of the front windshield. It was full of science and technology. After the tenth generation, e-devices were further increased, including satellite navigation, reversing image monitoring, car video/audio and car phone Bluetooth, which can be said to arm technology to the teeth.

The 12th-13th generation opened the era of sedan chair king.

In 2006, the 12th generation entered the China market with the concept of "entertaining family members", which set a brand-new benchmark for car models in comfort and economy, and at the same time brought out the title of "Nissan Big Sofa". By 2012, the 13th generation went on the market, achieving an overall improvement in technology configuration, and meeting the needs of families in the new era with more humanized and practical intelligent configuration.

The 14th generation of comprehensive innovation continues to be king.

The 14th generation has become an "ideal car for a new generation of families". Relying on the advantages of Nissan CMF super modular platform, the product strength has been improved in an all-round way. The appearance adopts the latest V-motion 2.0 design language of the family, and it adopts a slip-back shape, which is handsome and compelling. At the same time, it also reaches the low drag coefficient of 0.26Cd of the GTR level of Nissan super sports car, which reduces the air resistance by 14% compared with the previous generation. The central control design and intelligent technology have been greatly improved, and you can still feel the taste of home when you sit in it, but with a little more technology, the unique IFCW over-the-horizon collision warning at the same level, EAPM accelerator misplacement correction, IDA intelligent fatigue driving warning system and IDM intelligent highway stability system have not been compromised in space, and the comfort of the rear seats is still satisfactory. The power part is equipped with the brand-new 3rd generation HR16 intelligent engine, which highlights the four cutting-edge engine technologies, and emphasizes that the advantages of the whole powertrain are economy and stability, and the fuel consumption of 4.9L/100km is comparable to that of hybrid vehicles.

Summary:

The king is never achieved overnight. From 1959 to 2019, every generation always faces every consumption evolution, and builds family cars that conform to the times according to the needs of users and their own cutting-edge technology, thus bringing the best partners to every family, climbing from 80,000 units/year to 470,000 units/year, and winning the "2018 China Auto Market Championship". As of April this year, domestic sales have already been achieved.

1905 movie network news A few days ago, the movie was showing! The film is directed by,, starring,, and starring in friendship. Through a sketch of the ups and downs of the life of Yu Tie (played by Bao Beier), the film presents the most authentic and lively northeast rivers and lakes and northeast customs to the audience, and shows the warmth of Yu Tie’s brave pursuit of love and his family’s daily life to the fullest.

On November 1st, the film released the movie episode "I can’t resist your face" MV sung by Bao Beier, which incorporated Yu Tie’s undying love for Jin Jiali into the notes, making people cry. Since the film was customized, it has attracted the attention of many viewers. After it was launched, it triggered widespread discussion on platforms such as Tik Tok and Weibo, especially the video of crying while eating at Tietie, which made many netizens call it "Defensive" and the popularity of the whole film soared.

The movie "Love Brother in the Northeast" tells that in Harbin in the late 1990s, young Yu Tie (Bao Beier) fell in love with the borrower’s daughter Jin Jiali (Liang Songqing) at first sight when collecting debts, so he launched a fierce pursuit offensive against his old sister, but an accident happened when he was about to impress the goddess … … Yu Tie was set up by a social elder brother who was soft in heart and treated his emotions seriously with the appearance of "big slag smell". After the film went online, there were countless circles.

The movie episode MV "I can’t resist your face" released this time will integrate Yu Tie’s feelings for Jin Jiali into the notes. The phrase "You seem to have never seen me before, just let my dream become empty" sings Yu Tie’s voice, and many netizens commented "I am distressed by the iron" after watching the MV. Through the image language and the design of the details of their interaction, the film presents the undying love of Yu Tie and Jin Jiali to the audience delicately, and the open ending at the end of the film also leaves the audience with infinite reverie — — Jin Jiali wears a ring on the ring finger of her right hand. Some netizens think that she wore a ring for Yu Tie, and some viewers think that this is Jin Jiali’s last words to listen to Yu Tie and find her lover again.

In addition to vividly describing the love between Yu Tie and Jin Jiali, the movie "Northeast Love Brother" also shows the affection and fetters of Yu Tie’s family incisively and vividly — — The brotherhood between Yu Gang (Qiao Shan) and Yu Tie, and the affection between Yu Tie and his father are all touching. In particular, the scene in which Yu’s father thought that Yu Tie had made a mistake and knelt down at the police station, as well as the crying of Yu Gang and his daughter-in-law when they received the light box of the hair salon sent by Yu Tie, all aroused the resonance of netizens: "Amnesia took away a lot, but it could not take away his father’s instinct to love children." "When my grandfather died, my mother cried like this." The film refines people’s daily experiences in love, affection and life for more than 100 minutes, so everyone can find their own shadow more or less from the film.

　　At present, Aouita has built its own moat in the field of intelligence, with the joint help of Changan Automobile, Huawei and Contemporary Amperex Technology Co., Limited, and there is only one brand that Huawei really participates in the R&D, production and supply, that is, Aouita and Aouita have created a new world of their own in the field of intelligence, and the first model Aouita 11 has been listed, which is regarded as the embodiment of wisdom in the automobile industry. Taking advantage of the trend, positioning the new high-end intelligent coupe GT model Aouita 12 is also coming to us.

　　This is the official preview of Aouita 12, and it is also the declaration map in the declaration information of the 374th batch of new cars. The design of the vehicle continues the maverick of Aouita brand. Headlights mainly with light bands have the effect of being surrounded by abnormity, and we can also see the coupe design with convex sides and concave center in the engine compartment. The lower air intake grille will lower the visual center of gravity of the vehicle, and the annular enclosure formed by the headlight group passes between the lower grille and the front bumper, which has become one of its personality symbols.

　　Aouita 12 has a long wheelbase of 3020mm, a body of 5020mm and a width of 1999mm. In the rear design, the tendency of the vehicle’s hatchback is still very obvious, but because the vehicle actually uses a panoramic canopy to combine the roof structure with the rear windshield, it is closer to the sliding back in the tailgate style, which is more smooth and coordinated than the Krypton 001.

　　As an intelligent vehicle, Aouita’s most outstanding performance is naturally its intelligent driving. In terms of power, Aouita 12 will continue to be equipped with Huawei DriveONE drive system, and provide two power specifications: rear rear drive and front and rear dual-motor four-wheel drive. The power parameters of the front and rear motors are 195 kW/280 N m and 230 kW/370 N m respectively, which are completely consistent with Aouita 11. Under the same level of dynamic parameters, coupled with the low drag coefficient brought by the coupe modeling, it can be seen that Aouita 12 has stronger data performance on the performance output level.

　　Aouita 12 had the only electronic exterior rearview mirror that was legally put on the road in China before the project. According to the Performance and Installation Requirements of Indirect Vision Devices for Motor Vehicles issued last year with the national standard number of GB15084-2022, this kind of rearview mirror has been recognized. At present, Aouita 12 has also become the first and only model successfully declared and mass-produced in China. Compared with the traditional rearview mirror, this design is better in both the blind spot and the adjustment mode.

　　Aouita has achieved an all-round lead in intelligent driving and other aspects. In this context, the strong launch of Aouita 12 is certainly not bad. As for what glory it can create in the future, let us wait and see.

Welcome to Autohome Shanghai Promotions Channel to bring you the latest car information. At present, high-profile models are undergoing large-scale promotions, and car buyers in Shanghai will have the opportunity to enjoy a cash discount of up to 30,000 yuan. The minimum selling price of this luxury sedan has been adjusted to 199,800 yuan, which undoubtedly provides consumers with an excellent opportunity to buy a car. If you are interested in Hongqi EH7, don’t miss this rare opportunity. Click "Check Car Price" in the quotation form now, and contact the dealer as soon as possible to get more specific preferential policies and higher discounts to start your distinguished driving experience.

As a luxury business car, the Hongqi EH7 shows the side design of elegance and power. The body size is 4980mm*1915mm*1490mm, and the wheelbase is up to 3000mm, ensuring a spacious interior space and a comfortable ride experience. The precise layout of the front wheelbase of 1645mm and the rear wheelbase of 1655mm gives the vehicle excellent stability. The tire size is 245/50 R18, and it is paired with a streamlined wheel design, which not only provides good grip, but also adds a sense of mobility and fashion to the vehicle. Overall, the side lines of the Hongqi EH7 are smooth and full of power, highlighting its extraordinary identity and taste.

In terms of interior design, Hongqi EH7 adheres to the concept of both luxury and technology. The car is wrapped in exquisite leather to create an elegant and comfortable atmosphere. The steering wheel is made of advanced leather to provide a good grip, and supports manual up, down, and front and rear adjustment to ensure that the driver can easily find the ideal position. A large 15.5-inch central control screen stands in front, equipped with an advanced automatic speech recognition control system, which can easily control functions such as multimedia, navigation, telephone and air conditioning, showing the intelligent side of technology.

In the seat part, the Hongqi EH7 is made of imitation leather and leather/flip material, which is not only comfortable to the touch, but also has good air permeability. The main driver’s seat has four-way adjustment, including front and rear, backrest, high and low and waist support, providing comprehensive comfort support. The passenger seat also supports multi-directional adjustment to ensure passenger comfort. The front seat is also equipped with heating and ventilation functions, as well as headrest speakers, so the driver can enjoy a high-quality ride experience. In addition, the driver’s seat is also equipped with a power seat memory function, reflecting the thoughtfulness of user requests.

In terms of practical configuration, the car is equipped with two USB and Type-C ports in the front and rear rows to meet the charging needs of passengers. The front row is even equipped with a wireless charging function for mobile phones, highlighting the intelligent and user-friendly design of the Hongqi EH7. The rear seats support proportional reclining, providing passengers with flexible loading space to meet the travel needs of different occasions in an all-round way.

The Hongqi EH7 is equipped with a powerful engine with a maximum power of 253 kW, providing the driver with abundant power support. At the same time, the maximum torque of the engine is 450 Nm, ensuring that the vehicle can maintain good acceleration and responsiveness in all road conditions. The excellent performance of this engine undoubtedly enhances the overall driving experience of the Hongqi EH7.

In short, as the owner of Autohome said, the Hongqi EH7 has successfully captured the hearts of consumers with its unique design and exquisite craftsmanship. Whether it is the aesthetic pursuit of the appearance or the use of technology in the details, it shows the deep understanding and persistent pursuit of the Hongqi brand for high-end luxury cars. This car undoubtedly finds the best balance between luxury and innovation, bringing users a driving experience that exceeds expectations.

[Autohome Nanjing Discount Promotion Channel] Special report, this luxury car is currently under a striking promotion in the Nanjing market. Buyers can enjoy a cash profit of up to 219,600 yuan, which makes the minimum starting price drop to 219,900 yuan, bringing real benefits to consumers. To seize this rare discount opportunity, be sure to click "Check Car Price" in the quotation form to get the latest and most competitive car purchase price and strive for higher preferential treatment.

The exterior design of the Jaguar XFL continues the elegance and dynamism of the Jaguar brand. The front face adopts the classic Leopard air intake grille, with streamlined body lines, showing the perfect combination of power and refinement. The overall style combines sports and luxury, and the exquisite treatment of details makes every place exude a unique British atmosphere, whether it is on urban roads or highways, it can attract the attention of everyone.

As a luxury sedan, the Jaguar XFL has elegant and dynamic side lines. The body size is 5102mm*1890mm*1456mm, and the wheelbase reaches 3100mm. This body ratio makes it visually wide and coordinated. The front and rear wheelbases are 1605mm and 1609mm respectively, ensuring stable driving performance. The front and rear tires are 245/40 R19, and the delicate wheel design not only enhances the vehicle’s sense of mobility, but also enhances the grip and comfort when driving. Overall, the side design of the Jaguar XFL fully reflects the brand’s pursuit of detail and quality.

The interior design of the Jaguar XFL reflects its luxurious and refined British style. The high-quality leather material provides a comfortable touch for the driver and passengers. The steering wheel is wrapped in leather, which not only has an excellent grip, but also is equipped with electric up and down + front and rear adjustment functions to ensure that the driver can find the best driving posture in different driving conditions. The center console is equipped with an 11.4-inch touch screen with clear display effects and intelligent automatic speech recognition control system, which is convenient for the driver to operate multimedia, navigation and phone functions.

In terms of seats, the seat design of the Jaguar XFL pays attention to detail, providing front and rear adjustment, backrest adjustment, high and low adjustment and multi-directional adjustment of waist support to ensure comfort during long-distance driving. The front seat is also equipped with an additional heating function, while the driver’s seat is also equipped with a power seat memory function, providing the owner with a personalized driving experience. In addition, there are USB and Type-C ports in the car to meet the charging and multimedia needs of passengers, and the front area also provides wireless charging function for mobile phones, which enhances the convenience of use.

The Jaguar XFL is powered by a 2.0T turbocharged engine with 250 horsepower and a maximum power of 184 kilowatts. The engine delivers 365 Nm of peak torque and is paired with an eight-speed automatic transmission to ensure smooth and efficient driving.

Summarizing the owner’s evaluation, the Jaguar XFL won his favor with its unique exterior design. The owner described the body lines as simple and stylish, exuding youthful vitality, and the iconic design of the front face made him love it. The air intake grille of the China Grid complements the car logo, showing the classic aesthetics of Jaguar. For drivers who pursue personalization and a sense of design, the Jaguar XFL is undoubtedly an ideal choice.