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Today, the film Hot Search, directed by Xin Yukun and starring Zhou Dongyu, Song Yang and Justin, was officially released, which was the first to open the curtain of the year-end Lunar New Year file. In the previous premieres and roadshows, the passion of fighting against the powerful and voicing for the weak in the film directly hit people’s hearts, and the film’s delicate portrayal of the realistic details also gained a lot of praise. Some viewers bluntly said that the film was "pleasantly surprised and moved" and "from God’s perspective, I saw the whole process of public opinion reversal, and director Xin Yukun told a story worthy of everyone’s deep thinking". Xin Yukun, the director, said frankly, "I hope we can see the complexity behind online public opinion and bring the power of this kind voice to everyone.".

At the same time, the film also released a set of posters behind the hot spots. Behind the constantly reversed hot topics, there is a confrontation and game between rescuers and abusers, while the victims are surrounded by topic entries like "warning lines". A "network public opinion war" for justice is about to start.

Aspect 1:

Xin Yukun sharply portrayed the "network public opinion field"

Audience: A comment can save lives or kill people.

"This is an era in which comments can save people and kill people." The film Hot Search focuses on the complex network environment and shows a fierce and realistic "network public opinion war". Faced with the "industrial chain of choosing concubines on campus" involved by the girl’s online rampage, wealthy businessmen tried to cover up the truth and reverse black and white, and how the weak used the power of public opinion to launch a counterattack. A contest between good and evil about justice became more and more fierce. In the film, the plot of "public opinion confrontation" also made the audience feel fresh and wonderful. "The conscience choice from the media, the ups and downs of the Internet, the public’s emotions influenced by public opinion, the goodness and ugliness of human nature … all these are presented one by one in the fast-paced and skillful deep expression".

Aspect 2:

Expose the "interest chain of choosing a concubine" that sends a girl from a desk to a wine table.

Audience: Pointing at reality, shocking.

In the film, a group of self-media people voiced the sexually assaulted girls, and the "campus interest chain" revealed behind the truth also made many viewers bluntly "shocking". Under the banner of charity, wealthy businessmen actually sent girls from desks to wine tables, turning public welfare schools into their own "paradise for choosing concubines". After watching the movie, many viewers said that the relevant plot of the movie reminded people of many similar real events and called "The movie shines into reality". Some viewers said, "The realistic theme is crazy again. The vitality and daring of this film is not in the visual sense, but bloody tears open some illusions, allowing you to face the most real social situation."

Aspect 3:

Zhou Dongyu plays an "imperfect rescuer" to speak for the weak.

Song Yang Justin’s role is full of viewers sighing "what a surprise"

This time, Zhou Dongyu changed her old screen image and played an "imperfect rescuer", with a sharp side and a soft side, which was commented by the audience. "The good is not pure, and the evil is not pure. The dark side and the bright side make her a three-dimensional character." Song Yang and Justin also broke the comfort zone in the past and boldly challenged the new role boundaries. Song Yang plays a "middle-aged social animal" trapped by interests in the film, and the complexity of human nature is vividly displayed in him. Yuan Hong blessed devil wears prada, who played an evil role in the end with gold-rimmed glasses, and did whatever he wanted with power. His wonderful interpretation of the villain also received a lot of hot comments, which was "too annoying".

Aspect 4:

Complex human nature is intriguing, and hidden details are everywhere.

Audience: It’s worth two brushes to savor.

After the premiere and the road show, the delicate and complicated group images in the film also aroused the audience’s strong realistic resonance. The "self-media squad" who speaks for justice all the way, the victim girl who helps each other, the principal who does evil in the name of good, the mother who gives in to reality, and the secretary who becomes an accomplice from the victim ….. Each character in the film reflects different aspects of human nature, which is thought-provoking. The various details hidden in the film also attracted a lot of discussion after the screening, such as the metaphor of coffee, the mirror setting of the relationship between characters, the music played in the office, and the appearance of the behind-the-scenes bosses ….. which made many viewers bluntly say that it was "worth pondering".

Aspect 5:

Every time you make a sound, it has a vital force.

Audience: Defending the truth is defending conscience.

At the seminar held before the film, Hot Search also won unanimous praise from experts, such as "being close to reality", "showing network power" and "calling for rational voice". In an era when online public opinion can be either a dagger or a sword, everyone is prone to get caught up in the whirlpool of public opinion and lose their direction. Some viewers also said with their hearts, "Thanks for the movie ‘ Darkness ’ Exposed to ‘ Sunshine ’ Next, take us to see the whole picture of the online world, and also take us to find the direction of justice. " Self-media people who speak out for justice in movies have also constantly brought strength to everyone, igniting the passion of the audience to speak out for justice. "Defending the truth means defending conscience, and even weak resistance will condense into a storm."

The film "Hot Search" is produced by iQiyi Film (Beijing) Co., Ltd., Beijing Polymerization Film Culture Media Co., Ltd., Oriental Meizhi (Beijing) Film Co., Ltd., Huaxia Film Distribution Co., Ltd., Zhongming Shengshi (Shenzhen) Film Group Co., Ltd. and Phoenix Legend Film Co., Ltd., Beijing Baina Qiancheng Film Co., Ltd., Zhongjing E-sports Entertainment Co., Ltd., Wushuang (Shenzhen) Film Co., Ltd., Junze Film (Ltd. Oriental Meizhi (Beijing) Film Co., Ltd., Beijing Juyinglian Culture Media Co., Ltd. and Iqiyi Film (Beijing) Co., Ltd. issued, Huaxia Film Distribution Co., Ltd. and Shanghai Taobao Film Film and Television Culture Co., Ltd. jointly issued, and the film is being shown.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."