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Original pediatric doctor Yan, pediatric doctor Yan

Since the second half of 2023, Meituan and JD.COM Platform have carried out rapid home nucleic acid detection in some cities. At present, the testing items are as follows:

There are always parents who ask me: Is the quick test of nucleic acid at home accurate or not?

In fact, doctors and colleagues and I often discuss this issue. Our feeling is that sometimes it is accurate and sometimes it is not.

Through nearly half a year’s contact, we found that the rapid detection of nucleic acid at home is helpful to analyze the cause of upper respiratory tract infection in the community. In particular, the newly added pertussis test is convenient for early investigation and is really useful.

However, the detection rate of individual pathogens is doubtful, and some testing items seem unnecessary.

Here are two valuable cases. These two children not only did a quick home nucleic acid test, but also measured a very accurate tNGS (targeting high-throughput sequencing), which can be compared and analyzed.

As always, thank parents for their consent before sharing.

01

Case 1

A 7-year-old child saw a doctor at 12 noon on June 21st. The medical history is as follows:

When I saw a doctor, I had been coughing for 5 days. Because his deskmate was recently diagnosed with whooping cough, according to the clinical diagnosis standard B of CDC in the United States, if other diseases are excluded, whooping cough can be clinically diagnosed without laboratory tests.

Considering the 14-day course of antibiotic treatment and whether the family members take post-exposure prevention, after discussion with parents, it was decided that the presence of pertussis should be determined by rapid examination in JD.COM, and the drug-resistant pertussis infection should be evaluated by targeted sequencing. The specific plan is as follows:

At 15: 16 (more than 2 hours after sampling), the quick test results show that:

At noon on June 22nd (the second day after seeing a doctor), targeted sequencing showed that:

Through this case, we can draw the following conclusions:

1. The Bordetella pertussis detected this time is accurate (confirmed by sequencing).

2. The Streptococcus pneumoniae strain detected this time is false positive (negated by sequencing).

Why is there a false positive?

It is speculated that the primer design for rapid detection of Streptococcus pneumoniae in laboratory has defects and insufficient specificity, and Streptococcus angina with similar nucleic acid sequence is mistaken for Streptococcus pneumoniae.

3. The Haemophilus influenzae detected this time is accurate (confirmed by sequencing).

4. Targeted sequencing can identify whether there is drug resistance gene mutation in Bordetella pertussis, which is convenient for drug selection.

Reminder again: We must seize the opportunity to treat pertussis, because at present, drug-resistant pertussis is the main epidemic in China, so compound sulfamethoxazole is recommended as the first choice for empirical treatment.

▲ Guidelines for diagnosis, treatment and prevention of whooping cough in China (2024 edition)

02

Case 2

3 years and 7 months, I saw a doctor on July 13th (Day 2), and my medical history is as follows:

Initial diagnosis of acute laryngitis (mild). Because the symptoms suggest viral infection (especially parainfluenza virus), no pathogenic test was made at the first diagnosis.

The children returned home with high fever that day, and the parents made a quick inspection of the US delegation. The results are as follows:

You see, the US Mission has detected three kinds of "conditional pathogens" quickly, but there is no parainfluenza virus detection project, which makes parents feel strange.

In the next few days, the progress of this child’s illness is worrying.

On the 14th (Day 3), repeated high fever, the highest is 40.1℃.

On the 15th (Day 4), the highest temperature was 40.7℃. I went back to the clinic for targeted sequencing.

On the 16th (Day 5), sequencing showed that:

On the 16th (Day 5), the child developed yellow tears. His body temperature was 39.7℃ during the day and nearly 40.1℃ at 10 pm. My parents contacted me.

Combined with the sequencing results and the change of symptoms, I considered the virus combined with bacterial infection, and started amoxicillin and clavulanate potassium that night.

On the morning of the 17th (Day 6), the body temperature gradually dropped and pus increased. My temperature has been normal since the afternoon of the 17th.

Through this case, we can draw the following conclusions:

1. The Streptococcus pneumoniae strain detected this time is false positive (negated by sequencing).

2. The Pseudomonas aeruginosa detected this time is false positive (negated by sequencing).

3. The Haemophilus influenzae detected this time is accurate (confirmed by sequencing).

4. The parainfluenza virus detected by sequencing is the pathogenic pathogen that causes the initial symptoms of children, but the detection project has been cancelled by Meituan (which has been kept by JD.COM Quick Inspection so far).

5. The sequencing results are helpful for judging the virus combined with bacterial infection, and this result is also the basis for my difficult decision to start antibiotic treatment at 11 o’clock on the 16th.

03

Is home nucleic acid testing accurate or not?

Any new thing can’t be perfect, there will always be some problems that need to be constantly improved and improved.

Since it is an improvement, it should be improved as possible.

For example, it is very good to add pertussis and group A streptococcus detection items to the home quick inspection.

However, the US Mission cancelled the parainfluenza virus detection and increased the detection of Pseudomonas aeruginosa and Klebsiella pneumoniae with low value, which is puzzling.

Pathogen detection is very important for the management of some infectious diseases, so we should have higher requirements, which is not too much.

If the test results are inaccurate, some pathogens will always be false positive, which will not only lead to patients’ (or their families’) worries, but also lead to wrong intervention, increase the doctor’s interpretation cost and waste the doctor’s time.

The two cases I cited earlier are just cases, which are not convincing enough. Whether home nucleic acid is accurate or not depends on a large sample survey.

We can collect enough home nucleic acid and targeted sequencing results, and then analyze the difference of pathogen positive rate; If a patient has done home nucleic acid and targeted sequencing at the same time, the control analysis is more valuable.

Ben WeChat official account plans to write a series of articles to discuss how to manage common upper respiratory tract infectious diseases by home quick check-up.

Here, I especially hope that the testing organization will make this product better. For example, quality control personnel should carefully analyze the test data, find out the reasons for the high detection rate of pathogens such as Streptococcus pneumoniae, resume the detection of parainfluenza virus, and cancel some unnecessary tests.

In order to make a more rigorous evaluation, we collect home nucleic acid test results from readers, and the requirements are as follows:

1. Provide a complete test report screenshot. If there are other pathogen detection reports (such as targeted sequencing or antibody detection results), they can also be provided together. Please cover the patient’s name.

2. Sampling sites (such as throat swab and nasopharyngeal swab) can be provided.

3. Can inform the patient’s age, main symptoms (such as fever, cough, runny nose) and city.

https://www.wenjuan.com/s/uuqEBnn/

Thanks for your support.

The pediatrician slides up to see the next one.

Original title: "Quick test of nucleic acid at home, is it accurate or not? 》

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On February 28,Country GardenAn inside story was announced on the Hong Kong Stock Exchange, that is, Ever Credit Limited Company filed a lawsuit against the Hong Kong High Court yesterday (February 27th).Country GardenThe liquidation petition. The contents of the petition are related to the petitioner (lender) andCountry GardenUnpaid term loans with principal of about HK$ 1.6 billion and accrued interest between (borrowers).

According to section 182 of the winding-up ordinance, ifCountry GardenThe final liquidation by petition is made on or after the commencement date without the approval order of the High Court.Country GardenThe transfer of shares will be invalid.

In this regard,Country GardenIt is said that the company will strongly oppose the petition. The submission of the petition does not mean that the petitioner can successfully liquidate the company. On the date of the announcement, the Hong Kong High Court did not issue a liquidation order to liquidate it. The company will seek legal advice and take all necessary actions to actively and properly defend it with the consulting team.

According to the announcement, the Hong Kong High Court has set May 17, 2024 as the date for the first hearing of the petition.

Affected by this message,Country GardenOn the 28th, the Hong Kong stock market opened sharply, and once fell more than 12% in intraday trading. As of midday, its share price fell to HK$ 0.63 per share, with a market value of HK$ 17.633 billion.

According to the inquiry, Ever Credit Limited (Forever Credit Limited) was established in 2009, and it is a Hong Kong company that has obtained a money lender license under the Money Lenders Ordinance (Chapter 163 of the Laws of Hong Kong). Its parent company is Jiantao Group.

Jiantao Group is an investment holding company mainly engaged in manufacturing and selling copper-clad panels.Country GardenOne of the shareholders of.

According to the announcement issued by the group in August 2023, Ever Credit Limited worked with it on December 1, 2021.Country GardenA financing agreement was concluded and a term loan of HK$ 1.88 billion was lent. At that time, both parties agreed to repay the loan by installments.

“Country GardenThe debt amount of the Jiantao Group involved is very low in the overall interest-bearing liabilities abroad, and the radical action of a single creditor will not have a significant impact on the company’s security, normal operation and overall restructuring of overseas debts. "Country GardenAspect to interface news representation.

Insiders pointed out that,The petition for liquidation is the right of every creditor, and any creditor can apply for it, but the application does not mean that it will be liquidated.Referring to other cases of listed real estate enterprises in default in the industry, it is more common for individual creditors to apply to the Hong Kong court for company liquidation.

Since the liquidity crisis appeared in August last year,Country GardenA series of measures, such as salary reduction for senior executives, reducing administrative expenses and selling back domestic bonds, have been implemented to "save themselves" to alleviate the liquidity pressure at this stage.

In terms of debt handling, as of now,Country GardenNine domestic bond extensions have been completed, involving a total principal of about 14.7 billion yuan, and the maturity has been extended by three years as a whole. This isCountry GardenIn a short period of time, it eased some debt pressure.

In terms of overseas debt,Country GardenAt present, there are 15 public dollar bonds with a principal of about 9.3 billion US dollars. Last October,Country GardenAccording to the company, the company has started the restructuring of overseas debts, and hired CICC and Hualian Nuoji (China) as financial consultants to help assess the company’s capital structure and liquidity and formulate overall solutions.

In addition to the debt crisis, it is currentlyCountry GardenGenerally speaking, it is still more important to ensure delivery and operation.

according toCountry GardenThe latest disclosure in January, January-December 2023,Country GardenMore than 600,000 houses have been delivered, with a total delivery area of 71.62 million square meters, involving 249 cities in 31 provinces.

By 2024,Country GardenThe estimated delivery volume of will exceed 480,000 sets, according toCountry GardenYang Huiyan, Chairman of the Board of Directors, said earlier that,Country GardenThe delivery challenge of has entered the "deep water area" this year.

With the gradual landing of the "white list" of real estate projects and the continuous optimization of real estate financing policies,Country GardenofThe financing situation also ushered in a new situation.

according toCountry GardenInsiders recently revealed that at presentCountry GardenThere are 135 projects approved to enter the "white list", and these shortlisted "white list" projects will receive financing support, which will help alleviate.Country GardenAt present, the financial pressure is pushing forward the guarantee of delivery, asset revitalization, and improving the sustainable operation ability of the project.

　　Sina Auto News Guangqi Honda’s official 10th Accord was officially released today, and the official price of the 10th Accord was announced on the spot. The new car is equipped with 1.5T turbocharged high/low power engines, and six models are launched, with the price range of 169,800-229,800 yuan. The new car will be officially launched in May.

　　1. Brand-new design style, slip-back body, and the overall shape is more youthful.

　　2. Equipped with Honda SENSING security system.

　　3. The kingpin model is equipped with a 1.5T high-power engine with a maximum power of 195PS.

　　The 10th generation Accord has adopted a brand-new design style in appearance, and the chrome-plated decoration is just right. The front face has a brand-new U-shaped big mouth and front face design, and it is equipped with full LED headlights. The front of the car creates a front dive effect, and the new car keeps the middle-sized car calm, but it also looks like a young change.

　　For the first time, the slip-back body lines are adopted on the side of the car body, and chrome trim strips are added at the position of the C-pillar triangular window, so the overall shape is very slender. The length, width and height of the new car are 4893/1862/1449mm and the wheelbase is 2830mm respectively.

　　The tail line is very sharp, and the proportion of each part is in place. The boomerang taillight shape and the exhaust layout of both sides create a good sports temperament for the new car.

　　In terms of interior, the new Accord adopts a flatter center console design, and its steady style is quite a bit of a German car. The three-spoke multi-function steering wheel has a thicker shape and better visual effect, and the interface of the full LCD instrument panel has also adopted an updated design style.

　　In terms of configuration, the tenth generation Accord will be equipped with tire pressure monitoring, electronic parking, LED low beam lights, LED daytime running lights, leather seats, dual-zone air conditioning, rear air outlet, ANC active noise reduction, one-button start, and rear row down. At the same time, the new car is equipped with Honda SENSING safety system, including collision mitigation braking system, lane departure warning/suppression system, ACC adaptive cruise with low-speed follow-up, lane keeping, traffic sign recognition system, blind spot monitoring, 360-degree image and parking assistance, etc. The safety configuration is very rich.

　　In terms of power, the tenth generation Accord is equipped with a 1.5T high/low power engine and a high power version of the 260TURBO model, with a maximum power of 195PS and a maximum torque of 260 N m/1600-5000rpm. The low-power version of the 230TURBO model has a maximum power of 177PS and a maximum torque of 230 N m/1500-3000 rpm. The transmission will be matched with CVT gearbox.

　　In addition, the tenth generation Accord hybrid model will be released at the 2018 Beijing Auto Show and is expected to be launched in the third quarter of this year.

　　Toyota Camry, the traditional enemy of Accord, was just introduced into China years ago. The two generations are so close apart and similar in concept. Both of them adopt younger design elements and put aside the strong business atmosphere of their predecessors to attract young consumers. In the future, the two will also launch a fight in the market. Comparatively speaking, Buick Regal, Volkswagen Magotan and other models in the mid-level car market still retain a strong business temperament, and there will be a big competition between young and stable market in the future.

　　The design of the 10th generation Accord is in sharp contrast with that of the previous generation, and its strong sportsmanship turns the target user group to the young consumer group. At the same time, the new car has also made many changes for young users from the power level to the configuration level. From the strong power output to the introduction of more fashionable and internet-based configurations, we can see that Guangqi Honda is full of sincerity, and the arrival of the new Accord will inevitably stir up the mid-level car market.

In recent years, reports about "superbug" are common. It is no longer just the concern of medical workers, but has become a global problem.

"Superbacteria" actually does not refer to a specific bacteria, but generally refers to those bacteria that show resistance to at least three kinds of commonly used antibacterial drugs in clinic. Its academic name is "multi-drug-resistant bacteria".

In the face of "superbugs", only by understanding their characteristics and transmission mechanism can we better slow down their production and curb their spread.

"past lives" of Multi-drug Resistant Bacteria

Penicillin was discovered by alexander fleming in 1928. This powerful "sharp weapon" for treating bacterial infections saved countless lives in World War II. However, with the widespread use of penicillin and other antibacterial drugs, the first superbug in history-methicillin-resistant Staphylococcus aureus appeared, and then more and more superbugs appeared.

According to the report of China Bacterial Resistance Monitoring Network, the main clinical problem in China is Gram-negative bacilli which are resistant to carbapenems. The data in the first half of 2023 showed that the resistance rate of Acinetobacter baumannii to carbapenems was as high as 79.5%. These shocking data highlighted the seriousness of bacterial resistance in China.

In 2022, the authoritative medical magazine The Lancet published a survey of 204 countries and regions around the world in 2019. The study showed that antimicrobial resistance directly led to more than 1 million deaths, which even exceeded the number of people killed by malaria or HIV infection; The number of indirect deaths is even more alarming: nearly 5 million people. In 2016, the global research report on drug-resistant bacteria infection commissioned by the British government showed that by 2050, nearly 10 million people will lose their lives every year due to antimicrobial resistance.

Dr Margaret Chan, former Director-General of the World Health Organization, once pointed out that with the increasing and spreading of multidrug-resistant bacteria, common infection may once again become a fatal threat. This is not an alarmist. When human beings encounter the dilemma of no medicine available, even trivial wounds or respiratory infections may easily take their lives, and human beings will undoubtedly return to the dark period before the discovery of penicillin.

Why do drugs "fail" to bacteria?

Drug resistance of bacteria refers to the tolerance of bacteria to antibacterial drugs, which can be divided into congenital drug resistance and acquired drug resistance. Congenital drug resistance refers to the innate tolerance of bacteria to certain antibacterial drugs, which can be passed down from generation to generation; Acquired drug resistance means that bacteria "acquire" drug resistance genes due to spontaneous gene mutation or from other drug-resistant bacteria. Drug-resistant bacteria usually refer to acquired drug-resistant bacteria.

Drug resistance of bacteria is actually the result of natural selection in the process of evolution. In the process of its growth and reproduction, the reasons for promoting drug resistance involve many aspects, such as gene mutation or variation of bacteria, improper use of drugs and decreased immunity of the body, which may be the potential reasons for drug resistance.

The abuse of antibacterial drugs is an important factor leading to bacterial drug resistance. "Abuse" is mainly manifested in two aspects: unreasonable use in the treatment of human diseases and excessive and improper use in animal husbandry. Due to the selection pressure of antimicrobial agents, those bacteria with drug resistance will be naturally selected and multiply, thus accelerating the reproduction and spread of drug-resistant bacteria.

Multi-drug-resistant bacteria are mainly transmitted through contact, such as blood, sputum, urine or secretions of patients carrying multi-drug-resistant bacteria; Or contact with equipment, fabrics and pools contaminated by multi-drug resistant bacteria; For respiratory tract infection or colonization of multidrug-resistant bacteria can also be spread through droplets.

Antibacterials that have been "misunderstood"

The public’s understanding of antibacterial drugs is relatively limited, which leads to drug abuse becoming a common problem. There are 10 common misunderstandings in the use of antibacterial drugs, which need to be corrected as soon as possible:

1. Antibacterials are omnipotent anti-inflammatory drugs;

2. Do not distinguish the causes of colds, and use antibacterial drugs;

3. Antibacterials are the first choice for fever;

4. Diarrhea is inflammation, and it is best to use antibacterial drugs;

5. Broad-spectrum antibacterial drugs have stronger antibacterial ability, and the therapeutic effect is often better than narrow-spectrum antibacterial drugs for specific pathogens;

6. Newly listed and expensive antibacterial drugs are preferred;

7. The combination of multiple antimicrobial agents can effectively control infection;

8. It doesn’t matter if antibacterial drugs are frequently replaced;

9. Self-preventive use of antibacterial drugs during the high incidence of respiratory diseases in winter and spring.

10. The medication is not standardized, not enough, and the medication will be stopped if the symptoms improve slightly.

Abuse of antibacterial drugs will not only lead to bacterial resistance, but also lead to a series of serious adverse reactions, among which allergic reactions are particularly common, such as itchy skin, rash and other symptoms, and even life-threatening conditions such as anaphylactic shock may occur in severe cases; Some drugs may also cause nervous system symptoms, such as headache and dizziness. Some antibacterial drugs can also have toxic effects on hearing and kidneys; Abuse of antibacterial drugs will destroy the balance of flora in the body, which will cause a large number of inhibited bacteria to multiply and cause double infection.

Standardize drug use and prevent drug resistance

Remember 7 points.

1. Don’t buy drugs at will: Most antibacterial drugs belong to the category of prescription drugs. You must issue a doctor’s prescription when buying them, and you can’t buy them online or in a physical pharmacy at will.

2. Don’t choose your own medicine: When choosing which kind of antibacterial drugs to use, it should be judged by professional doctors according to the condition and clinical test results, not just by advertising or personal experience.

3. Do not use drugs at will: When using antibacterial drugs, we should follow the doctor’s advice to ensure that they are taken after professional diagnosis in the hospital, and do not blindly abuse drugs, especially for some daily ailments (such as colds), it is not appropriate to use antibacterial drugs easily.

4. Do not stop taking drugs without authorization: Once you use antibacterial drugs, you must follow the doctor’s instructions and take the drugs on time, according to the dosage and according to the course of treatment.

5. Pay attention to personal hygiene: frequent hand washing, more ventilation and avoiding close contact with patients are helpful to prevent infection.

6. Strengthen exercise: enhance physical fitness and immunity, and reduce the use of antibacterial drugs from the source.

7. Don’t throw drugs at will: expired drugs belong to harmful waste, so they should be thrown into the hazardous trash can to prevent criminals from recycling them. Garbage sorting, protect yourself and others.

The doctor concluded:

The increasingly serious problem of drug-resistant bacteria has become a major challenge in the field of global public health, which is attracting widespread attention from the medical community, government and society. In daily life, we should pay attention to developing healthy living habits, ensuring clean diet, actively exercising to enhance our immunity, and at the same time, we should follow scientific principles and standardize the use of antibacterial drugs. The whole society needs Qi Xin to work together to slow down the emergence of drug-resistant bacteria and curb its spread.

Text | Shen Chunmei

Deputy Chief Technician, Department of Hospital Sense, Fifth People’s Hospital Affiliated to Fudan University

Editor | Wang Jingming

Audit | Ye Haixia

Producer | Li Wenjing

Medical Support | Shanghai Medical Association Science Popularization Branch

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CCTV News:During the Spring Festival, local consumption ushered in a "good start". In Chongqing, the average daily flow of Guanyinqiao business district exceeded 800,000 person-times, and the catering consumption of shopping malls in the business district increased by over 50% year-on-year; In Tianjin, Jinjie Business Circle organized nearly 50 non-legacy exhibitions and built new consumption scenes, with an average daily turnover exceeding 100 million yuan, a record high; Hubei issued coupons for the Spring Festival, and Wuhan Shopping Mall launched the Spring Festival Garden Party, with the passenger flow increasing by about 20% compared with the same period of last year. Six days before the Spring Festival holiday, the amount of duty-free sales in Hainan Island exceeded 1.9 billion yuan, and the number of duty-free shoppers was 234,700. This Spring Festival, the Xidan business district in Beijing has been completely renewed. All kinds of dragon element products, as well as a series of domestic fashion products combining traditional folk arts such as pottery sculpture and paper cutting, are welcomed by young consumers. Since the Spring Festival holiday, the department stores, supermarkets, specialty stores, restaurants and e-commerce enterprises monitored by Beijing Municipal Bureau of Commerce have achieved sales of 6.59 billion yuan, an increase of 37.4% over last year’s Spring Festival holiday.

Ministry of commerce: service consumption is heating up obviously, and the goods of daily necessities are abundant and stable.

During the Spring Festival, the sales of holiday goods and service consumption in the whole country increased year-on-year, the goods of daily necessities were abundant and the prices were stable, and the online payment transactions in the whole industry also continued to grow.

The reporter learned from the Ministry of Commerce that from the first day to the fifth day, the sales of festival goods are booming. The Ministry of Commerce focused on monitoring the sales of green organic food, gold and silver jewelry of retail enterprises, which increased by more than 10% year-on-year.

Service consumption has obviously warmed up. Focus on monitoring the e-commerce platform accommodation turnover increased by over 60% year-on-year. Among them, the turnover of villagers’ houses around Harbin has increased by more than three times.

The necessities of life are abundant and the prices are stable. According to the business big data monitoring of the Ministry of Commerce, there are sufficient stocks of grain, oil, meat, eggs and vegetables in 100 large-scale agricultural and sideline products wholesale markets nationwide; The prices of grain, edible oil, pork, beef and mutton, chicken and eggs were basically the same as before the holiday, while the prices of vegetables decreased by 1.2%.

According to the data of the People’s Bank of China, from the New Year’s Eve to the fifth day of the Spring Festival, the online payment transactions handled by Networked Clearing Company and China UnionPay continued to grow, with a total of 15.38 billion transactions, amounting to 7.74 trillion yuan, up by 15.8% and 10.1% respectively. Among them, consumption scenes such as catering, accommodation, tourism, retail, film and television entertainment are particularly favored, with year-on-year growth of more than 20%.

Passenger flow in national key business districts increased by 70% year-on-year, spending more yuan.

During the Spring Festival holiday, various localities have continuously enriched the supply of cultural tours and launched various and colorful activities, and many scenic spots and business districts have shown a thriving scene.

According to big data, from the 23rd of the twelfth lunar month to now, the total passenger flow of key business districts in China has increased by 73% year-on-year. Compared with the same period of last year, among the top 10 shopping districts, Jie Fangbei Pedestrian Street in Chongqing, Datang Pedestrian Street in Xi ‘an, Beijing Road Pedestrian Street in Guangzhou and Harbin Central Street Pedestrian Street appeared. Business districts with their own characteristics are also meeting the consumption needs of different groups of people. Pedestrian streets with distinctive styles attract more foreign tourists, and the proportion of foreign tourists in Chengdu Kuanzhai Lane Pedestrian Street and Changsha Huangxing South Road is over 75%. In the Bazaar shopping district in Lhasa and the Grand Bazaar pedestrian street in Urumqi, the proportion of consumers under 30 is relatively high, and the unique architecture, various handicrafts and ethnic delicacies attract a large number of young tourists.

The total box office of this year’s Spring Festival movies reached 7.328 billion yuan.

According to the data of the network platform, as of 17: 25 on February 16th, the Spring Festival in 2024 (February 10th — On February 17th, the total box office (including pre-sales) of movies was 7.328 billion yuan. YOLO’s Pegasus 2 and Boonie Bears: Time Twist are still in the top three box office temporarily.

In addition, according to the data of the online platform, as of 16: 31 on February 16th, the total number of movie-goers in the Spring Festival in 2024 reached 146 million (including pre-sales), exceeding the total number of movie-goers in the Spring Festival in 2018 by 145 million, making it the second largest in China film history.

This Jiachen the Year of the Loong Spring Festival holiday, from culture and art, non-genetic inheritance to eating, drinking and having fun, cultural tourism consumption is full of vitality;

Spring Festival Lantern Festival, folk performances, non-legacy experience, parade to celebrate the New Year, various forms of entertainment, the whole holiday is full of flavor.

In the thick flavor of the year, citizens’ tourists are enthusiastic about traveling and spending, and many scenic spots and business districts show a booming scene.

It can be described as full of popularity, prosperous consumption and strong annual flavor.

Visitors to Hong Kong during the Spring Festival holiday are expected to reach about 750,000.

A spokesman for the Hong Kong SAR Government said recently that the number of visitors to Hong Kong during the Spring Festival holiday is estimated to be about 750,000, which has reached the level of the same period in 2018. Among them, 650,000 people were mainland tourists, exceeding the same period in 2018. According to industry insiders, the overall occupancy rate of Hong Kong hotels during the Spring Festival holiday reached 90%, and various Spring Festival celebrations were well received by citizens and tourists.

Macau’s Spring Festival tourism market is booming, and the number of inbound tourists has increased significantly year-on-year

During the Spring Festival, the Macao SAR government held a golden dragon parade, floats and fireworks display, which attracted many tourists from home and abroad. According to the preliminary data released by Macao officials on February 16, from February 10 to 15, the number of inbound tourists in Macao was about 1,075,700. On the first three days of the Lunar New Year, the number of inbound tourists in Macao increased by more than 200% year-on-year, and the average occupancy rate of hotels reached 90%.

Harbin, Heilongjiang: During the Spring Festival, the ice and snow tour continued to be hot, driving accommodation and catering consumption.

During the Spring Festival this year, the tourism market in Harbin, Heilongjiang Province continued to be hot, and the number of tourists in major scenic spots reached a record high. According to the data provided by Harbin Municipal Bureau of Culture, Radio, Film and Tourism, from February 10 to 14, the city received a total of 6.298 million tourists, an increase of 82.9%.

The popularity of ice and snow tourism has also driven the consumption growth of local catering, accommodation and other related industries. According to the survey data of some key industries by Harbin Municipal Bureau of Commerce, the turnover of accommodation industry in Harbin increased by 22.90% compared with the same period of last year from February 10 to 13, and the turnover of catering industry enterprises increased by 51.55% compared with the same period of last year.

Zhengzhou, Henan Province: Consumption increased significantly during the Spring Festival, and the turnover of shopping malls increased.

During the Spring Festival, the consumption of many large commercial centers in Zhengzhou, Henan Province was hot, and gold jewelry, restaurants, movies and other projects became hot spots of consumption. Many business districts have also launched a series of preferential activities to meet the diverse needs of consumers. In order to attract consumers, some shopping malls have also integrated into the local urban characteristics, and opened up performance areas to make dramas, concerts and other performances in shopping malls, providing rich Spring Festival experiences for citizens and tourists.

According to the statistics of Zhengzhou Municipal Bureau of Commerce, as of February 15th, during the Spring Festival holiday, the passenger flow of large-scale commercial complexes in Zhengzhou totaled 2,743,800, a year-on-year increase of 5.58%. The total turnover was 451 million yuan, an increase of 9.75% compared with the same period in 2023.

Dunhuang, Gansu: The tourism market continues to heat up during the Spring Festival.

During the Spring Festival, Dunhuang, Gansu ushered in the first peak of passenger flow in 2024, and the tourism market continued to heat up. Enjoy the beautiful scenery during the day and watch the performance at night. In Dunhuang, tourists started the "white+black" play mode. During the Spring Festival, the cave-style immersive experience drama "Music in Dunhuang" opened a different cultural journey for tourists. Museums, bookstores, research activities, etc. have also attracted many tourists to punch in, feel the desert customs, and learn more about Silk Road culture and celebrate the Spring Festival.

It is understood that on the fifth day of the Lunar New Year, the six scenic spots in Dunhuang received a total of 25,340 tourists, and in 2024, they received a total of 201,114 tourists, an increase of 103.34% over the same period in 2023.

Wuhu, Anhui: 12,000 jobs will be provided at the Spring Festival job fair.

Now the recruitment and job hunting after the Spring Festival has begun. On February 15th, a Spring Festival job fair was held in Wuhu City, Anhui Province, providing 12,000 jobs and attracting more than 20,000 job seekers. The whole job fair attracted 341 companies to recruit, covering manufacturing, modern agriculture and other fields, providing 12,000 recruitment positions. The reporter visited and found that many enterprises have an urgent demand for front-line operators, and there is a big gap in technical jobs such as assembly, numerical control and electrical engineering. In order to recruit talents, enterprises have offered good salary conditions.

According to preliminary statistics, the job fair attracted more than 20,000 job seekers to apply, and 8,600 job seekers registered on the spot.

CCTV News:The second season of "Ding Luo Long Dong Choke" will be launched at 19: 30 on September 16th, and will be replayed at 22: 30 on CCTV-1 comprehensive channel and 20:30 on CCTV-11 drama channel that night.

Hui Minli, the quiet partner of the sincere goddess who loves Shaanxi opera.

There is a "contradiction" between tranquility and Hui Minli, a performance artist of Shaanxi Opera. Quiet practices lying fish outdoors in high temperature. When you feel tired, your arm is just about to be put down. Teacher Hui on the side sternly "reprimands" Quiet not to be lazy. Quiet sigh: "Mr. Hui is so fierce. He stressed several times that he has special circumstances and is not suitable for sitting often. I found that I am still suitable for being a teacher and not suitable for being a student."

Quiet partner, Qin Opera performance artist Hui Minli

Comedy big coffee Song Xiaobao partnered with Xiong Zhuying, the storyteller of northern Shaanxi

As an out-and-out Northeastern, Song Xiaobao came to northern Shaanxi to live and eat with Xiong Zhuying’s family, and felt the charm of northwest culture. He shouted: "Shanxi and Shaanxi are stupid and confused, and there are gullies everywhere. It is very difficult for me to jump into the ravine." When communicating with Xiong Zhuying about Errenzhuan and storytelling culture in northern Shaanxi, Song Xiaobao confessed that the reason why "Haiyan, you can grow up" was because you forgot the words.

Song Xiaobao partnered with Xiong Zhuying, the storyteller of northern Shaanxi.

Tiger Hu, a creative genius, partnered with Zhang Jianmin, the inheritor of Huayin old tune.

Tiger Hu was the first star to be exposed in the second season of Ding Luo Long Dong Choke, especially her partner inheritor’s interpretation of Huayin old tune, which inevitably made people compare it with Sitar tan’s performance of "Huayin old tune" which blew up the audience in CCTV Spring Festival Evening. However, Tiger Hu said: "I feel particularly honored that Huayin Laoqiang was the first to know about it, but I didn’t know much about it. Later, Sitar tan performed at the Spring Festival Evening, and now he knows more and more about Huayin Laoqiang. This time, he went to Shuangquan Village to learn from Teacher Zhang Jianmin. I think it is very tasteful, and I think it is something in the bones, very powerful and very energetic. "

Tiger Hu partnered with Zhang Jianmin, the storyteller of northern Shaanxi.

Aestheticism singer Alan partnered with Haidong Lu, the fifth generation inheritor of Lu Pai Suona after 90.

Alan visited Xunyi and followed Haidong Lu, the inheritor of the 1990s, to learn to play suona in the cornfield. When exchanging their hard experiences in learning musical instruments with Haidong Lu, he said, "Learning musical instruments is very hard, others played when I was a child, but I practiced for two or three hours, which was actually very common when I was a child. My parents forced me to learn, and sometimes when my parents were not paying attention, I set the alarm clock up for half an hour, or played it again with a repeater, pretending that I practiced very hard. However, Haidong Lu wants to learn by himself. It is really not easy to be so young and still be able to persist hard. " During the recording, it coincided with Alan’s birthday. Without her prior knowledge, Haidong Lu’s family also prepared a birthday cake and a happy birthday song for Alan, and Haidong Lu’s mother even made a pair of cloth shoes for Alan herself, which promoted her righteousness step by step.

Alan partner suona inheritor Haidong Lu.

For most office workers, the first demand for buying a car is to travel instead of walking, and considering practicality, many of them can meet this requirement. For a car, you can’t talk about heroes purely by the quality of dynamic performance, just like other aspects of performance are also worth talking about. The following small series will tell you in detail.

Let’s take a look at the appearance of Mercedes-Benz EQE first. The design of the front of Mercedes-Benz EQE takes a comfortable route and looks more rounded. Then the simple headlight design is adopted, and the visual effect looks quite clean and refreshing. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, automatic steering, delayed closing and so on. Come to the side of the car, the car body size is 4969MM*1906MM*1514MM, the car uses cold lines, the car body looks very young, with large-sized thick-walled tires, it looks full of sports. Looking back, the overall shape of the rear of the car echoes the front face, and the taillights look very unique, and the whole looks very fashionable and sporty.

In terms of interior, the interior presents a round design style, which is very simple and generous. The steering wheel of the car is very simple in shape, made of leather, and its practicality and face value are not bad. From the central control point of view, the central control screen with 12.8-inch touch OLED makes the interior design layered and looks exquisite. Let Xiaobian introduce the dashboard and seats. The dashboard design is remarkable and looks very fashionable. The car uses imitation leather seats, which are wide and thick and very comfortable to ride.

Mercedes-Benz EQE is equipped with a motor with a total power of 215KW and a total torque of 556N.m It has good acceleration, excellent cruising range and good power performance.

The car is equipped with car networking, driving mode selection, remote control key, interior atmosphere light, traction control (ASR/TCS, etc.) and other configurations, which is quite rich in functions, which is undoubtedly very friendly to drivers.

I wonder if you are excited about this car introduced today? If you are interested in it, you might as well learn more about it!

Topic: 2008 US Presidential Election

　　On August 23rd, Senator Obama of Illinois, who was firmly nominated for the US Democratic presidential nomination, announced that he had chosen Senator Biden of Delaware and Chairman of the Senate Foreign Relations Committee as his running mate. This is a photo of Biden (right) and Obama attending a TV debate in Johnston, Iowa, USA (photo taken on December 12, 2007). Xinhua News Agency/AFP

　　Xinhuanet Denver, USA, August 27th (Reporter Wang Wei) Senator Biden of Delaware officially became the vice presidential candidate of the Democratic Party in Denver, Colorado on the 27th.

　　That night, after a verbal vote, no one at the scene opposed Biden as the only vice presidential candidate. Speaker of the House of Representatives, Democrat Pelosi, immediately announced that Biden was positive.

　　Nomination. Biden made a speech announcing his acceptance of the nomination, and said that he would help Obama, who had been nominated as the presidential candidate, run for the next president, thus officially becoming the Democratic vice presidential candidate.

　　Biden emphasized his experience in diplomacy and national defense in his speech. He said that after visiting Georgia, Iraq, Pakistan and Afghanistan, he found that the Bush administration’s policy was an "unfortunate failure", so Americans could not live like this for another four years.

　　Biden believes that Obama’s policies can bring changes to the United States, change the tax system, improve the country’s economic situation, develop alternative energy sources, and reduce health care expenses. He also compared Obama’s and Republican candidate John McCain’s policy views on Iraq, Afghanistan and Iran’s nuclear issues respectively, and pointed out that Obama’s judgment in foreign and security affairs is trustworthy and capable of safeguarding national security.

　　Biden, 65, has served as a senator for more than 30 years and is currently the chairman of the Senate Foreign Relations Committee. He has rich experience in foreign affairs and national defense affairs and is regarded by American media and political analysts as the best candidate to make up for Obama’s lack of experience in this field.

　　After Biden’s speech, Obama unexpectedly appeared at the meeting. He was scheduled to arrive in Denver on the 28th to deliver a speech accepting the presidential nomination in a stadium that can accommodate 75,000 people.

　　Obama said that he was proud of Biden as the vice presidential candidate, and thanked New York Senator Hillary Clinton for turning to support him after the primary election failed. In addition, Obama also invited ordinary people to attend his speech on the 28th.

Editor: Meng Xu

Welcome to the Autohome Luzhou promotion channel, we bring you the latest car market trends. At present, the most talked about models are going through an unprecedented promotion. In the beautiful city of Luzhou, car buyers can enjoy a cash profit of up to 40,100 yuan, which further reduces the starting price of the already competitive Blue Electric E5 model to only 99,800 yuan. This is a car purchase opportunity not to be missed. Friends who want to seize this wave of discounts, please be sure to click the "Check Car Price" button in the quotation form to get more specific discount details and the best time to buy a car.

The Blue Electric E5 stands out among its peers with its exquisite body size, with a length of 4760mm, a width of 1865mm, a height of 1710mm, and a wheelbase of 2785mm, providing passengers with a spacious and comfortable interior space. Its front and rear wheelbases are 1585mm and 1580mm respectively, ensuring the stability and handling of the vehicle. It is worth mentioning that the Blue Electric E5 adopts uniform specifications of tires, and the front and rear wheels are equipped with 225/55 R18 tires. With a unique rim design, it not only enhances the visual effect, but also enhances the comfort and safety of driving.

In terms of interior, the Blue Electric E5 shows the perfect fusion of elegance and technology. The exquisite leather steering wheel not only provides a comfortable grip, but also supports manual up and down adjustment, which is convenient for the driver to adjust according to needs. The center console is equipped with a 12.3-inch high definition touch screen, whether it is a multimedia system, navigation or phone operation, it can be easily realized, and supports automatic speech recognition control, which greatly improves the driving convenience. The seat is made of imitation leather material, and the design focuses on comfort. The main driver’s seat has multi-directional adjustment functions of front and rear, backrest and height. The passenger seat also provides a variety of adjustment options to ensure the most comfortable riding experience for passengers. The rear seat supports backrest adjustment and has a proportional reclining function, which improves the flexibility of the space. The overall interior design is centered on practicality and humanization, creating a warm and technological interior environment.

The Blue Electric E5 is equipped with a 1.5L displacement L4 engine with a maximum power of 81 kilowatts, providing continuous power support for the vehicle. This engine has a strength of 110 horsepower, ensuring a smooth driving experience. With the E-CVT continuously variable transmission, power transmission is smoother and fuel economy is improved.

Summarizing the owner’s evaluation, he was full of praise for the driving experience of the Blue Electric E5. The gasoline-electric hybrid system and excellent suspension adjustment brought him more driving pleasure than expected. At the same time, his satisfaction with the interior space also reflects the practicality and comfort of this model. The domineering and safety of the exterior design also makes him deeply trusted. Among many new energy models, the Blue Electric E5 undoubtedly satisfies his dual pursuit of driving pleasure and quality of life.

Huang Hongsheng

　　　　 According to Taiwanese media reports, Huang Hongsheng died at home today (16th), was found dead, at the age of 36, the agent also confirmed the death, the news came out, shocked the entertainment industry, fans are sad and unbelievable, from the Rolling Stones period took care of him Ren Xianqi, at this time for the concert practice group, the agent dare not tell him the bad news.

　　Huang Hongsheng used to be taken care of by Ren Xianqi when he was at the Rolling Stones. When Ren Xianqi went to Huang Hongsheng’s program to promote the concert, Huang Hongsheng said emotionally: "In the past, we were embarrassed to ask seniors for help, but Brother Qi will take the initiative to assist the younger generation!" In the past, he also wrote emotionally: "Brother Qi has always been very junior, and when Rolling Stones was his junior brother, he was also taken care of by his brother." At that time, he praised Ren Xianqi even more: "This kind big brother without airs, helped me teach a lesson again, if it’s ok, I will also be such a big brother in the future."

　　Now that Huang Hongsheng died suddenly at home, the reporter called Ren Xianqi’s agent, who said that Ren Xianqi was currently rehearsing for the concert, "I haven’t let him know the news yet. He usually takes care of Huang Hongsheng very much. If he knew it, he would be very sad. I am afraid that it will affect his mood, so I will not let him know first.", also revealed that the last time the two met was on a show hosted by Huang Hongsheng. (ETtoday/article)