上海品茶

　　We have been exposed to vaccines since we were born. In fact, when you have no memory, you have already received the first vaccine!

A kind of vaccine:

　　1. BCG vaccine: the first injection at birth

　　You must have no memory of the first injection after birth. It is called BCG, and it is usually vaccinated within 24 hours after birth. It belongs to the national immunization program vaccine.

　　BCG vaccine is mainly used to prevent tuberculous meningitis and hematogenous disseminated tuberculosis.

　　Tuberculosis is very easy to spread through the respiratory tract. Patients with tuberculosis who excrete bacteria in sputum may inadvertently cough and expectorate the bacteria to exposed children, and the children may get sick with tuberculosis. Infants and young children have weak resistance and are more susceptible to tuberculosis infection. BCG vaccination in neonatal period can improve the specific resistance of infants and young children to tuberculosis.

　　2. Hepatitis B vaccine: within 24 hours of birth.

　　Within 24 hours of birth, babies should be vaccinated against hepatitis B. Hepatitis B vaccine, as its name implies, is used to prevent viral hepatitis caused by hepatitis B virus. It belongs to the national immunization program vaccine.

　　The planned immunization of hepatitis B vaccine should be injected with one dose at birth, one month and six months. If the serum protective antibody disappears in adulthood, it is necessary to strengthen the second vaccination of hepatitis B according to the nature of occupation and living environment. Hepatitis B was once the main disease that endangered the health of Chinese people. Vaccination against hepatitis B virus effectively protected children from infection and greatly reduced the incidence of liver cancer and cirrhosis in adults. Therefore, it is extremely important to vaccinate against hepatitis B..

　　3. Polio vaccine: the sweetest vaccine

　　Do you still remember "sugar pill" (live attenuated polio vaccine)? It is an oral bone marrow ash vaccine and belongs to the national immunization program vaccine.

　　Polio, also known as polio, will cause atrophy and deformity of lower limb muscles after getting sick, and lead to lifelong disability. Its vaccines are divided into attenuated live vaccine and inactivated vaccine.

　　At present, it is recommended that 2-month-old infants be vaccinated with one dose of inactivated polio vaccine, and children aged 3, 4 months and 4 years should take one "sugar pill" each, for a total of four times.

　　4. DTP vaccine

　　DTP vaccine can prevent pertussis, diphtheria and tetanus, and belongs to the national immunization program vaccine. At present, the incidence of pertussis is increasing in China, especially in infants, who are seriously ill. Therefore, it is very important to vaccinate pertussis vaccine in time in infancy.

　　After the child is born, he will be vaccinated for the first time at the age of 3 months. After that, vaccinate once at the age of 4 months and 5 months after birth, and the interval between each time shall not be less than 28 days; At the age of one and a half to two years old, another injection should be strengthened; Inject 1 shot of refined diphtheria vaccine at the age of 6.

　　5. DTP vaccine

　　DTP vaccine is the combined diphtheria and tetanus vaccine, which can prevent diphtheria and tetanus infectious diseases. It belongs to the national immunization program vaccine.

　　Inoculate 1 dose when the child is 6 years old.

　　6 measles vaccine (vaccine containing measles vaccine ingredients)

　　Measles is mainly transmitted through the respiratory tract, which is very contagious and seriously ill. It must be vaccinated on time. The vaccine belongs to the national immunization program vaccine.

　　At the age of 8 months, you can get the combined vaccine of measles and rubella, and then get the combined vaccine of measles, rubella and mumps again at the age of 18 months, which not only ensures the reliability of the monovalent measles vaccine, but also prevents rubella and mumps. If there is an epidemic situation of measles, the intensive immunization of susceptible people can play a positive role in controlling the epidemic situation and protecting susceptible people.

　　7. Japanese encephalitis vaccine

　　Japanese encephalitis is a zoonotic natural epidemic disease, which is an acute infectious disease of the central nervous system caused by Japanese encephalitis virus and spread by mosquitoes, with a high disability rate.

　　There are two kinds of Japanese encephalitis vaccines used in China: live attenuated Japanese encephalitis vaccine and inactivated Japanese encephalitis vaccine, and the live attenuated Japanese encephalitis vaccine belongs to the national immunization program vaccine.

　　The attenuated live vaccine was inoculated with two shots, which were inoculated at 8 months and two years old respectively; Four shots were given during the whole vaccination, two shots were given at the age of 8 months (the second shot was given every 710 days), and one shot was given at the age of two and six.

　　8. meningococcal vaccine

　　Encephalomyelitis is an acute respiratory infectious disease spread by airborne droplets. Generally, it occurs under the age of 15, especially children from 6 months to 2 years old are most susceptible to infection.

　　Among the vaccines to prevent meningococcal meningitis, group A meningococcal vaccine is mainly used for children aged 6 months to 18 months, and group A+C meningococcal vaccine is used for children over two years old and adults. It belongs to the national immunization program vaccine.

　　The specific vaccination method is that infants are vaccinated with the first and second doses of group A meningococcal vaccine at 618 months, and the interval between the two doses should not be less than 3 months; At the age of 3, the first dose of A+C meningococcal vaccine was inoculated. At the age of 6, the second dose of A+C meningococcal vaccine was inoculated.

　　9. Hepatitis A vaccine

　　Hepatitis A is an acute infectious disease spread through the digestive tract, mainly through contaminated food, causing acute viral hepatitis. Children and adults are susceptible.

　　There are two kinds of hepatitis A vaccines used in China: live attenuated vaccine and inactivated vaccine. At present, live attenuated hepatitis A vaccine belongs to the national immunization program vaccine.

　　Attenuated live vaccine was inoculated at the age of 18 months by one-dose inoculation procedure. The inactivated vaccine was inoculated in two doses, one shot at 18 months old and one shot at two years old.

Second class vaccine

　　10. Pneumococcal vaccine

　　Pneumococcal vaccine is currently a second-class vaccine, which is voluntarily vaccinated at its own expense. According to Professor Ceng Guang, the chief researcher of China Center for Disease Control and Prevention, among all vaccine-preventable diseases, pneumococcal disease is the leading cause of death of children under 5 years old in the world. In China, about 30,000 children under 5 years old die of various pneumococcal diseases every year. ④

　　Thirteen-valent pneumococcal polysaccharide conjugate vaccine standard procedure has a total of four injections, with three basic immunizations at the age of 2, 4 and 6 months, and one booster immunization at the age of 1215 months.

　　11. Chickenpox vaccine

　　Chickenpox vaccine is a second-class self-funded vaccine. Chickenpox, condyloma, chickenpox-an infectious disease caused by herpes zoster virus infection, is mainly spread by airborne droplets, and is highly contagious, especially in children. It is usually contagious 24 hours and 48 hours before the eruption. After suffering from chickenpox in childhood, the latent chickenpox-herpes zoster virus can be activated in adulthood due to low immunity, leading to the onset of herpes zoster.

　　Inoculate the first dose at 12 months old and the second dose at 4 years old.

　　12. Influenza vaccine

　　Chickenpox vaccine is a second-class self-funded vaccine, and some areas are free of charge for special people, such as the elderly over 60 years old. Influenza virus may mutate its antigen every year, which can make people repeatedly infected and sick, so the influenza vaccine strain may be updated every year.

　　Generally speaking, in the northern region, influenza begins to spread from October to February of the following year. It is recommended to vaccinate one month before the epidemic. Because influenza vaccine strains may be updated every year, and the immune protection produced by influenza vaccine generally lasts for 68 months, influenza vaccine needs to be vaccinated every year.

　　13. Rotavirus vaccine

　　Live attenuated rotavirus vaccine is a second-class self-funded vaccine. Almost all children under the age of 5 will develop rotavirus gastroenteritis because of rotavirus infection. The disease is highly contagious and spreads through the fecal route. Therefore, it is necessary for children to be vaccinated with rotavirus as soon as possible.

　　Domestic monovalent rotavirus vaccine at the age of 2 months?Vaccination at the age of 3 years, once a year, and three doses of imported pentavalent rotavirus vaccine, the first dose at the age of 612 weeks, and the third dose no later than 32 weeks, and the interval between each dose is generally 410 weeks.

　　14.EV71 vaccine

　　EV71 is the main virus that causes the epidemic of hand, foot and mouth disease in children in China, especially severe hand, foot and mouth disease is mostly caused by EV71 infection, and severe cases can be fatal. Therefore, China successfully independently developed the inactivated EV71 vaccine, which was used in the prevention of severe hand, foot and mouth disease in children in China in 2016, with good protection effect.

　　School-age children who are vaccinated with EV71 vaccine are 6 months old and 5 years old, and they are vaccinated with 2 doses, each with an interval of 4 weeks.

You need to know about vaccination!

　　1. How many vaccines should a person take in his life?

　　People should be vaccinated with at least 10 kinds of vaccines in their lifetime. First of all, the national free vaccines include BCG vaccine, hepatitis B vaccine, polio vaccine, DTP vaccine, Japanese encephalitis vaccine, epidemic cerebrospinal meningitis vaccine, hepatitis A vaccine, DTP vaccine, measles and rubella vaccine, and measles and measles vaccine.

　　In addition, there are chicken pox vaccine, rabies vaccine, influenza vaccine, pneumococcal vaccine, rotavirus vaccine, EV71 and other vaccines.

　　2. Rabies vaccine is the only life-saving vaccine without contraindications!

　　It is understood that the position document of the World Health Organization (WHO) on rabies vaccine, the relevant disposal specifications, technical guidelines and instructions for vaccine use issued by the state all clearly indicate that there are no contraindications to rabies vaccination after rabies exposure, and it is safe and effective for pregnant women to vaccinate rabies vaccine.

　　The fatality rate of rabies is 100%, so once a person is bitten by a dog, including pregnant women, the wound should be disinfected and cleaned first, and rabies vaccine and rabies immunoglobulin should be vaccinated as soon as possible.

　　According to previous statistical data, there is no significant difference between the incidence of adverse reactions of pregnant women injected with rabies vaccine and that of ordinary people.

　　In view of the high mortality rate of rabies, no matter whether pregnant women are bitten by cats, dogs and other animals at any stage of pregnancy, they must be vaccinated against rabies.

　　So please remember that rabies vaccine has no contraindications! No matter pregnant women or children, they can choose vaccination as long as there is a risk of infection. ⑩

　　3. What vaccines are self-funded and non-self-funded?

　　China is a developing country, and it is impossible to vaccinate all vaccines free of charge at present, so it is divided into free vaccines (vaccines within immunization program) and self-funded vaccines (vaccines without immunization program). No matter whether self-funded vaccine or free vaccine is inoculated, the corresponding diseases can be effectively prevented.

　　It is foreseeable that in China, more and more second-class vaccines will be included in the first-class vaccine. At present, some areas have given free vaccination against chicken pox vaccine, influenza vaccine and 23-valent pneumococcal vaccine for special susceptible groups such as the elderly and children.

　　4. Why should we observe for 30 minutes after vaccination?

　　Don’t leave immediately after vaccination. It’s best to stay in the hospital for 30 minutes, because the severe allergic reaction caused by vaccine is mostly 15 minutes after injection.?Show up in 30 minutes.

　　Some children have fever, itching, rash, local redness and other discomfort after injection. These are normal general reactions. When they have a fever, their body temperature is usually not high and will disappear after 12 days. Drink plenty of water if you have a fever. If you have a rash, obvious local redness and pain at the inoculation site or possible allergic reaction, you need to consult a doctor and deal with it accordingly.

　　5. Vaccines can also prevent cancer?

　　For liver cancer and cervical cancer, vaccination can play a preventive role. Although cancer is not contagious, some carcinogenic pathogens can be contagious, such as hepatitis B virus and human papillomavirus.

　　Zhuang Hui, an academician of China Academy of Engineering, said at the 19th national academic conference on viral hepatitis and liver diseases that 86% of patients with liver cancer were infected with hepatitis B virus, and 6.7% were infected with hepatitis B virus and hepatitis C virus. Strengthening vaccination is the most effective measure to prevent hepatitis B..

　　The occurrence of cervical cancer goes through the process of human papillomavirus infection, persistent infection, precancerous lesion and cancer. Zhang Jun, a professor at the School of Public Health of Xiamen University, said in an interview with Health Times that bivalent or tetravalent vaccine has the same effect in preventing cervical cancer, both of which can prevent 70% of cervical cancer, and the nine-valent vaccine can prevent 90% of cervical cancer.

Special feature of 1905 film network On the evening of February 14th, Lianrui Film announced that due to a major mistake in the schedule selection, its main film withdrew from the highly competitive Spring Festival file and was postponed to March 30th this year. February 15th was the last day for the film to meet the audience during the Spring Festival.

Viva La Vida tells the story of two seriously ill young people, Lu Tu and Ling Min, who finally see the sunshine of life because of relay for life. The film was warm and cured, and gained a good audience reputation. Douban scored 7.9, but at present, the box office is less than 100 million yuan, and the market performance is far below expectations. Here we also hope that good movies can be seen by more people.

In this special program of Spring Festival "Spring Festival Movies Booming", the director of Viva La Vida leads the leading role and walks into Blue Feather Living Room, which is the final chapter of Han Yan’s trilogy of life and is full of moving and healing power. In the interview, the main creator revealed the behind-the-scenes of the film for us.

Lan Yu: Just now we have been cycling the song "Shake the Sun" in a single.

Han Yan: Yes, I heard it when I was a child. "Don’t miss a good time", isn’t that the theme of our movie? I decided to use the name of this song as the title of the film.

Lan Yu: You two have been singing just now. Who sings better?

Peng Yuchang: She sings well. The emotional part must be that she sings well.

Li Gengxi: On the aspect of all five tones, it has to be him.

Lan Yu: How did the director first think of letting them play this movie?

Han Yan: At that time, the script was not completely finished, and I didn’t think in my mind who would play these roles. At that time, after meeting them, the role seemed to be more concrete in my mind. For example, Geng Xi looks very thin and small, but when chatting with her, I can feel that there are many special things in my heart, which is very similar to the role of Ling Min. What about Pumbaa? You see, he is always sincere and innocent, and so is his performance.

Lan Yu: Did you observe his innocent face?

Xu Fan: He is innocent. I think my son just wants to wake him up.

Lan Yu: Today we are about to usher in Pumbaa’s "social death" moment. Because Pumbaa actually performed in a variety show six years ago.

Peng Yuchang: I’m really sweating.

Han Yan: Very sincere and innocent.

Lan Yu: What kind of impression did you have on director Han Yan’s works at that time?

Peng Yuchang: Worship.

Han Yan: It’s so hypocritical. I just said that he is sincere.

Peng Yuchang: Worship, really, really.

Li Gengxi: I think he was very pure at that time. Now, after all, people are almost thirty, and there will still be one thing, that is, a sense of vicissitudes and a sense of story.

Lan Yu: I heard that the director said before taking this play that he could not take other plays for six months. Did he make such a request?

Han Yan: Right. Because I want them to spend as much time as possible immersed in the role to be played, I don’t trust that you can get into this role instantly by pulling away from the role in another play.

Li Gengxi: At that time, it happened that I hadn’t filmed for half a year. I was completely in the state of my own life, and then I could devote myself to this play. I have been with the role every day for five months, and this experience will be a very precious experience in my career.

Lan Yu: So this time you two should walk into different lives. What lessons did you do, Geng Xi?

Li Gengxi: Basically, I experienced the local life in Changsha. Later, we went to the hospital, visited those patients, talked with them and learned about their lives. The most striking thing is that it is too real, such as someone’s eyes, or a patient showed me a fistula in his arm.

Lan Yu: Geng Xi has many details in the movie, for example, she eats lemons. Does this detail come from these real patients?

Han Yan: I have observed that some patients’ daily life, such as eating lemons, including how they control salt, potassium and water, including some normal things, will be concentrated on Ling Min.

Lan Yu: Is it cool for Geng Xi to eat citric acid every day?

Li Gengxi: My teeth will be very astringent, and my mouth will be drooling all the time. My lips may be pickled and broken a little, and it will be very sour if I eat it again.

Lan Yu: What about Pumbaa?

Peng Yuchang: The patients we met were different. I think even before, you were afraid to touch life and life and death, but after talking to them, they gave me an optimistic, positive and sunny attitude, which made me ashamed. On the contrary, I am still a more sensitive person who may be afraid of this.

Lan Yu: This is what the film wants to present. It was a very interesting scene when you two met. Was it entirely the director’s design?

Han Yan: Right. Lu tu, like a stone, knocked the quiet lake out of the waves. A meeting changed Ling Min’s life and the direction of our movies, so I hope that meeting is interesting.

Lan Yu: What’s the code word?

Han Yan: "Ollie gives". This code word … Let me guess that Lu Tu is a state in which his life is always half a beat slower than this era. Maybe many people think that the slogan "Ollie gives" is out of date now, but I think it may be the exciting period for Lu Tu.

Peng Yuchang: "For Ollie", it took four days.

Lan Yu: Another scene is your confession on the rooftop. At that time, how did you understand Lu Tu’s courageous confession?

Peng Yuchang: They are like complementary souls, and they have feelings there. Let’s send out the most sincere ones.

Lan Yu: How did Geng Xi feel when he heard Pumbaa say that?

Li Gengxi: I will feel that this is the first time he has said something different from his usual. That feeling is quite complicated. There are new feelings about him, new feelings about himself, and the past and future of two people.

Lan Yu: I feel that I have more love in this world, and there is someone who really loves you.

Li Gengxi: Maybe love was not enough at that time, but I felt as if I had found a bosom friend.

Lan Yu: That’s very good. The director nodded frequently just now, and I feel that Geng Xi’s understanding of this character is actually very thorough.

Han Yan: Yes, because I think that feeling she just said, I’ve been thinking. For example, many people ask me why I always make such movies related to the theme of life. The birth of mankind itself is a great miracle. The chance of our parents meeting and combining and giving birth to us is one in four hundred trillion. These two people can still meet in this situation. In our play, it means that this is one in three hundred million. Therefore, the meeting of the two of them that night and the unpretentious dialogue, in my opinion, are quite moving feelings.

Peng Yuchang: In the wedding scene, the director really didn’t ask us so much, but let us finally follow our feelings.

Han Yan: It’s also the last scene. They have gone through all the processes of the whole movie.

Peng Yuchang: I just watched everyone, my mother and the teacher. When everyone was down there, I saw the director sitting at a table, as if I had accompanied Lu Tu and Ling Min through this journey in recent months. Tears welled up in my eyes, and I felt moved by that moment.

Han Yan: I said one thing that they didn’t know, that is, I hesitated all the time in the process of making this film. In the end, did he get married bald or grew a little hair? After his first haircut, I saw him show that scar. At that moment, I felt that I should show this scar to get married. We also gave Ling Min a close-up, and she didn’t wear cuff again. Those scars are a medal for them to overcome life, get rid of life’s predicament or get out of trouble.

Lan Yu: Pumbaa has a lot of courage. He dares to completely shave his head in this scene. But when I saw the real shave, Pumbaa still had some fluctuations in his heart. Geng Xi comforted him with special jokes, saying that you were more handsome after shaving, right?

Han Yan: It’s not a joke, it’s true.

Peng Yuchang: Actually, I’m a little scared. I’m really scared, but I think later, in fact, I’m right to be scared. Because Lu Tu said the second time, I don’t want to go into the operating room again. I don’t want to experience this life again. That fear is really the fear of facing hardships. Facing this life, the fear of this disease is right.

Lan Yu: They are really trying very hard to get close to this role and find their true feelings. Mr. Xu Fan, when you were working with them on the set, could you feel the seriousness and persistence of young actors in their performance?

Xu Fan: Yes, because I think they just tried their best to be immersed in the role. This is meaningful. I remember that when we filmed the scene of cooking, Pumbaa was very real. He was full and ate a lot after just one shot.

Peng Yuchang: I’ve been eating.

Xu Fan: But when the director said to do it again, he said to do it again? If I had known, I would have eaten less. At the beginning, he devoted himself to this role, so when I saw them both, I felt very vivid. These two children were so interesting, but they went to do theirs and I did mine. This is called separation between the old and the young.

Lan Yu: This movie is full of fireworks. It was shot in Changsha, which is a city that makes us feel very fireworks. Pumbaa’s Hunan Supu, did you ask any friends around you?

Peng Yuchang: Yes, I asked the teacher, and the group also prepared a language teacher for me.

Lan Yu: Have you got any secrets about Su Pu in Hunan?

Peng Yuchang: At first, I thought it was just a change in tone. After filming for about seven days, I was particularly impressed. Suddenly one day, the director said that you should stop talking like that. You can talk like this. That day, it was the first time that I realized that the pitch didn’t have to be raised so high, but it must be like Su Pu, and normal speech was also Su Pu.

Lan Yu: If you use Su Pu to describe the three people present, what would you say? First of all, describe mom.

Peng Yuchang: Here’s Ollie.

Lan Yu: Here it is from Ollie. What about the director?

Peng Yuchang: What the director said … was wrong.

Han Yan: It means a liar.

Peng Yuchang: Because he lied to me. That bald guy looks good.

Han Yan: I lied to you, but it’s not just bald. I lied to you a lot.

Lan Yu: I am happy to be fooled. Where is Geng Xi?

Peng Yuchang: It’s beautiful.

Lan Yu: This dialect is very important. It immediately established the life quality of this character, including Mr. Xu Fan, in which you also spoke dialect.

Xu Fan: Yes, because I’m from Hubei, and the plastic arts in Hubei are different from those in Hunan. What’s the ending in Hubei? This ending is different, and sometimes I’m particularly afraid of stringing, so I have to control myself from stringing at any time, because a string of Hunan people says it doesn’t look like it, and Hubei people will say it doesn’t look like it, so I have to control it as much as possible.

Blue feather: the waves behind the Yangtze River push the waves before. Geng Xi is a post-00 generation. It is very surprising for us to see her performance strength. Can you join such a movie? Will you have your own confused moments during the performance?

Li Gengxi: Every play is like a new beginning. Han Dao is very particular about details, so I can’t use my experience. Experience is the most worthless thing. You need to forget all these things, but you have to put yourself in that shell and be at the mercy of Han Dao. So this thing is a wonderful feeling.

Han Yan: You forgot that you sent me a message the other day. She said something to me at that time, which impressed me deeply. She said that I thought they were too difficult and I didn’t know how to help them. I also want to make myself a little less comfortable. This kind of touch or feeling can really make this character’s heart feel melted.

Li Gengxi: (with tears in his eyes)

Han Yan: Did you mention anything sad?

Li Gengxi: No, no, no.

Lan Yu: You suddenly recalled that feeling, didn’t you?

Li Gengxi: Yes, I just have to say how bad this whole thing is for me.

Han Yan: I want to explain to you that the two of them didn’t just suffer some flesh and blood when they played this role, because I always shoot this kind of drama myself. I know very well that every time I shoot this kind of movie, I shoot Fuck off! Tumor jun, whether filmed or filmed, is born and died once with the role. I am well aware of the pressure and struggle behind their performance.

Lan Yu: What kind of new understanding does director Han Yan have of life after filming the trilogy of life?

Han Yan: I have been particularly sensitive to birth, illness and death since I was a child. Later, I filmed these things by myself, which was a process of self-healing. Why did I keep filming? Because I have never been cured, that is, the medicine can’t stop. I think people will always have doubts about life when they are alive.

Lan Yu: "Shake the sun" reminds me of a picture, as if the feeling that the sun is shaking brighter and brighter is releasing more and more light. As long as we live hard and upward, we will be able to shake out the sunshine that belongs to our own life.

Han Yan: This is a movie with vitality and warmth.

Meierkholid (1874-1940)

　　Meierkholid, a Russian dramatist, finally returned to China in 2019, taking the opportunity of updating and republishing Meierkholid Conversation compiled by Mr. Tong Daoming. He is a genius who has been erased and is still underestimated. As the Russian director vakhtangov said, "In the near future, all dramas should be constructed and designed as predicted by Meierkholid." China’s theatrical circles are familiar with stanislavski, but they are still alienated from Meierkholid. Therefore, his "coming back" is particularly important to China’s plays.

　　In a curious and impromptu form, conversation can capture the pedigree of thoughts, the context of terms and the journey of words through colloquialism. In this way, Meierkholid’s Conversation bridged the theoretical gap, reappeared the past time and space, and we can remember the fierceness and habits of the master in his later years. The creation/breaking in art often exists in opposition to each other, accompanied by dazzling Gemini: for example, Dostoevsky is to Tolstoy, Ibsen is to Chekhov, and stanislavski (hereinafter referred to as Stani) is to Meierkholid. Stani is a boundary marker, and Meierkholid will always be a master of innovation. The beauty of Meierkholid is not in the desk, but in the theater; However, the writing on his desk is full of aura, shining with his discoveries, inventions and imagination everywhere.

　　Discovering "Hypothesis" and "Theater"

　　Meierkholid borrowed Pushkin’s words that "the essence of drama art lies in the fact that it is different from reality", and discovered the "hypothesis", which reversed Steiner’s "drama" and emphasized the "theater" of integration. He is an important turning point in the history of directing.

　　"Director" is an independent modern division of labor that began in the 19th century. It originated from the demand for identity and common experience in drama. A unified organizer can aggregate the theaters that have lost their internal binding power. "The origin of the director lies in the framed stage; His first success lies in the imitative stage; And his victory lies in the expressionist and dramatic stage. " For the first time, Duke Meningen played a unique role as a director: fully rehearsing, unifying performance style, conforming to historical costumes and dancing beauty, and realizing the dream of drama integration for centuries.

　　Stani also emphasized the overall design of "director-despot". At first, he gradually turned from external reality to internal reality with the help of external techniques such as sets and props, and pursued "more psychological realism". Stani takes the actor as the core and gives the performance dignity. These familiar terms: experience, through action, inner vision, role tone … … A realistic towering system has been established around actors, which has led for more than a century.

　　Stanny pursues realism and verisimilitude, while Meierkholid explores hypothesis and theater. Realism must admit the hypothesis, and the theater is not a place to reproduce the truth of life and psychology, but a space to express ideas with impressionistic actions. The stage is a platform for performance, not a realistic scene, and life must be transformed into a "theater" to be displayed on the stage. Theater is "the imagination of the audience can provide the rest of the things expressed in unused words"; Theater is not only the lines and the actions decided by them, but also full of all the factors of the stage. Assumption is the characteristic of all arts, and it also refers to a non-descriptive technique, which replaces reproduction with performance and constitutes a "drama" different from "drama" art. Meierkholid and Steiner parted ways from their origins, but they were not out of place, but came from different understandings of realism. The stage does not create illusion reality, but constructs non-illusion hypothesis; So he must invent certain hypothetical techniques.

　　What are "constructivism" and "organic modeling"

　　Meierkholid invented two symbolic terms: constructivism and organic modeling; Without an actor who can communicate and ready-made skills, he invented it and taught it to actors. The invention focuses on three stage factors: action, music and space. Action is no longer the shape outlined by language, but the display of concrete shape. Music is emotional contagion’s time, and it is expressed through the spatial image, thus completing the spatialization of time. The Imperial Envoy is designed according to the sonata, and each new improvisation is a change of theme.

　　Drawing lessons from constructivism sculpture — — Various planes and materials are connected by various lines such as glass strips or steel wires, and an anti-realistic constructivist stage is constructed: the curtain is cancelled, the empty walls are exposed, and the lights are not concealed; The stage is equipped with a combination of platforms, slopes, escalators, runways, railings, roulette, etc., such as scaffolding for building, which is also a necessary fulcrum for actors’ activities. Meierkholid observed Sicilian actor grasso’s understanding of the skills between characters’ emotions and modeling, and summarized them into twelve or three kinds of modeling training. Organic modeling requires actors to receive various trainings in gymnastics, circus and ballet, which is plastic and becomes a magical engine, similar to Gordon Clay’s "super puppet" and suitable for the style of the machine age: strong physique, strong sense of rhythm and accurate movements; Let the whole body participate in our every movement.

　　From the director’s style, he was influenced by Appiah’s plastic stage and lighting skills and Clay’s "screen setting". Although they closely linked the director with the aesthetic program and eventually made it the common language of an international movement, their achievements stopped at an anti-naturalistic stage setting skill. It is Meierkholid who really makes the stage and actors blend into the overall director style.

　　A kaleidoscope of theater exploration

　　The pursuit of theatricality has made Meierkholid move from the stage center to the theater center. The performance is as unpredictable as a kaleidoscope, and it will be amazing to sort out his exploration path.

　　1906 -1907: Directed the mystery play Nun; Masked comedy "Vaudeville Artist"; The expressionist drama A Life of Man. 1908: Directed O ‘Flo, Don Juan and Masquerade, carried out novel ideas and found that it was necessary to start with actor training. 1913 -1917: Developed a unique performance method from masked comedies in ancient Greece and Italy; In the rehearsals of "Mysterious farce" and "Earth-shaking", film screening, jazz music and hexagonal accordion were used to match the noise of the machine. 1922: The Generous Tortoise and Death of Tarelkin, with mature constructivism, adopt the form of farce, and have the roles of clowns and vagrants. 1924: "Give me back Europe" adopts "movable wall" and projection. The stage changes rapidly much like a movie montage, and the lighting also fully shows the dynamics. 1925: The Power of Attorney adopted a screen setting. In 1924, "The Forest" used a mask, divided into sections without a curtain, and the sections were connected by pantomime, with subtitles on the screen, which can be said to be an early "narrative drama". In 1926, "An Imperial Envoy" adopted a platform set with one master and three assistants, and adopted a sonata.

　　Meierkholid tried all kinds of modernist styles, and their scope dwarfed the directors, forming a unique "Meierkholid habit". His rehearsal is impromptu, one way to stage a scene, and then another way in a few days. Improvisation requires superb skills and rich imagination in order to be vivid. Not only that, but also learn from various arts, creatively make the stage film and change the scene flexibly.

　　Meierkholid was extremely revolutionary, attacked and deprived of the theater. He honestly defended his views, and arrest and death followed. It was not until the thaw in the 1950s that he was officially reburied and his plays were staged again.

　　In the last performance of La Traviata, he gave up constructivism and adopted realistic scenery. And from the mechanical outside to the actor’s inner emotions. The most famous is the three meetings between Armand and Margaret, which were designed to be scattered three times according to different plots and emotions: the petals that met for the first time; Scraps of paper from the second proposal; The third coin with negative gas separation forms a stage expression vocabulary. Over time, he will certainly find the hypothetical way to externalize his inner emotions.

　　"At first, you were a maverick innovator, and later you became the founder of the white-haired tradition", which became a prophecy. Modern culture has the ability to assimilate dissidents and turn pioneers into classics. Meierkholid always looks like a clank of iron, but it is full of vitality and strength. As his proud disciple Eisenstein paid tribute to him, "When I am old, I will feel that I am not worthy to kiss the dust under his feet." (Zhou Quan)

1905 movie network news A few days ago, the movie was showing! The film is directed by,, starring,, and starring in friendship. Through a sketch of the ups and downs of the life of Yu Tie (played by Bao Beier), the film presents the most authentic and lively northeast rivers and lakes and northeast customs to the audience, and shows the warmth of Yu Tie’s brave pursuit of love and his family’s daily life to the fullest.

On November 1st, the film released the movie episode "I can’t resist your face" MV sung by Bao Beier, which incorporated Yu Tie’s undying love for Jin Jiali into the notes, making people cry. Since the film was customized, it has attracted the attention of many viewers. After it was launched, it triggered widespread discussion on platforms such as Tik Tok and Weibo, especially the video of crying while eating at Tietie, which made many netizens call it "Defensive" and the popularity of the whole film soared.

The movie "Love Brother in the Northeast" tells that in Harbin in the late 1990s, young Yu Tie (Bao Beier) fell in love with the borrower’s daughter Jin Jiali (Liang Songqing) at first sight when collecting debts, so he launched a fierce pursuit offensive against his old sister, but an accident happened when he was about to impress the goddess … … Yu Tie was set up by a social elder brother who was soft in heart and treated his emotions seriously with the appearance of "big slag smell". After the film went online, there were countless circles.

The movie episode MV "I can’t resist your face" released this time will integrate Yu Tie’s feelings for Jin Jiali into the notes. The phrase "You seem to have never seen me before, just let my dream become empty" sings Yu Tie’s voice, and many netizens commented "I am distressed by the iron" after watching the MV. Through the image language and the design of the details of their interaction, the film presents the undying love of Yu Tie and Jin Jiali to the audience delicately, and the open ending at the end of the film also leaves the audience with infinite reverie — — Jin Jiali wears a ring on the ring finger of her right hand. Some netizens think that she wore a ring for Yu Tie, and some viewers think that this is Jin Jiali’s last words to listen to Yu Tie and find her lover again.

In addition to vividly describing the love between Yu Tie and Jin Jiali, the movie "Northeast Love Brother" also shows the affection and fetters of Yu Tie’s family incisively and vividly — — The brotherhood between Yu Gang (Qiao Shan) and Yu Tie, and the affection between Yu Tie and his father are all touching. In particular, the scene in which Yu’s father thought that Yu Tie had made a mistake and knelt down at the police station, as well as the crying of Yu Gang and his daughter-in-law when they received the light box of the hair salon sent by Yu Tie, all aroused the resonance of netizens: "Amnesia took away a lot, but it could not take away his father’s instinct to love children." "When my grandfather died, my mother cried like this." The film refines people’s daily experiences in love, affection and life for more than 100 minutes, so everyone can find their own shadow more or less from the film.

1905 movie network news Organized by the movie channel, Jackie Chan and other 100 stars initiated and participated in the "Fight Against Poverty — — The "Starlight Action" public welfare project officially launched its third stop in Jiangcheng Hani and Yi Autonomous County, Yunnan Province. Jiangcheng County is located in the south of Yunnan, which is named after Li Xianjiang, Man Laojiang and Meng Yejiang. It also borders Vietnam and Laos, hence the saying that "one city connects three countries".

On September 15th and 16th, the project team led by Cao Yin, director of the program center of the film channel, and the actor Huang Xiaoming’s team will complete the poverty alleviation research activities here. The research work of this trip is mainly divided into three parts: visiting the trail of Asian elephants to find a way to get along with each other, visiting poor families in the whole wasteland, and conducting on-the-spot and detailed investigations on the local tea industry.

This "fight against poverty — — The poverty alleviation research of Starlight Action focuses on ecological poverty alleviation and industrial poverty alleviation, and discusses the benign interaction between ecological protection and economic development. The arrival of the team has been warmly welcomed by the local people. The Propaganda Department of Yunnan Provincial Party Committee and Pu ‘er Municipal Party Committee and Municipal Government attached great importance to it. They said, "Fighting poverty — — It is a good thing that "Starlight Action" focuses on local problems, attracts social attention with the help of the influence of stars, publicizes local characteristic industries and inspires people.

　

Huang Xiaoming explores the tracks of Asian wild elephants on the spot.

Name the newborn elephant baby "Nuannuan"

　

After carefully reading "The Battle against Poverty — — After the information provided by the advance team of "Operation Starlight", Huang Xiaoming chose the "wild elephant" in Jiangcheng, Yunnan Province as the research direction of precision poverty alleviation. In addition to the natural protection value of this precious and rare wild animal, Huang Xiaoming thinks that perhaps through field visits, we can further explore the eco-tourism resources and help the local people find a unique way out of poverty.

In fact, nearly a quarter of the Asian elephants in the world live in Jiangcheng. Although they are very cute as rare animals, they trample on food in the process of migration and foraging, threatening the personal safety of villagers, and indeed bringing troubles to the local government and villagers. How to protect human life and production resources while protecting Asian elephants? How people and elephants live in harmony is also the answer that Huang Xiaoming wants to pursue in this trip.

On the morning of September 15th, the poverty alleviation research team set out for Dajiaoshu Village, Kangping Town. Soon after getting off the bus, Huang Xiaoming and his party passed a field with signs of destruction. According to the inspector of the same trade, three or four days ago, a group of wild elephants "passed by" from here, gnawing the corn planted by fellow villagers, leaving big footprints on the land on both sides. Following the footprints, Huang Xiaoming felt even more distressed when he saw the trampled farmland, and repeatedly apologized to the villagers for the elephant. The elder sister of the villagers on the side said with open mind, "Although I am very distressed and even a little scared, there are so many wild elephants living here, which also shows that our environment is good, and these elephants look particularly simple and honest."

Huang Xiaoming was very moved by the villagers’ love for elephants, but he was still very concerned about whether everyone’s life and property safety had been effectively guaranteed. At present, the local authorities have strengthened the early warning and monitoring of the whereabouts of wild elephants. In addition to timely issuing notices through WeChat and other communication methods, each village group has also installed high-pitched broadcasts to timely notify the villagers to protect their personal safety.

According to the inspector’s 24-hour careful monitoring, they found that there were 23 wild elephants near the villagers’ group recently. Along their tracks, Huang Xiaoming and the research team further explored the mountains along the road. With the help of drone equipment, they successfully monitored this group of wild elephants under the canopy. At the sight of the picture, Huang Xiaoming could not but let out a scream.

In the lens, elephants are playing and foraging in the Woods. According to the drone aerial photographer, most of the elephants are females, and several males often struggle for higher ethnic status. Huang Xiaoming listened to the introduction of the aerial photographers with relish, and under the guidance of professionals, he personally piloted a drone for observation. In the process, he also found a baby elephant playing under his mother’s stomach. This is a little male elephant, which was just born four months ago.

The inspectors warmly invited Huang Xiaoming to give the baby elephant a name, which made him both surprised and caught in a little tangle. After thinking about it, Huang Xiaoming chose the name "Nuannuan", which is the deepest feeling he got from the local people after he came to Jiangcheng — — Simple, kind and warm, including in the face of wild elephants, these villagers also chose tolerance and protection, which made Huang Xiaoming very touched.

After following up for a certain distance, Huang Xiaoming and the team did not continue to approach the wild elephant for the sake of protecting the safety of the wild elephant and the personnel themselves. The data shows that in recent times, the distance between people and elephants did not exceed 100 meters. The good ecological environment and rare wild elephants made Huang Xiaoming very excited at the end of the first inspection tour, and strengthened his confidence in the poverty alleviation plan for the development of local ecological resources.

At the same time, with his personal experience and understanding of the local situation, he also thought more seriously about how to coordinate the development of "man and nature" in Jiangcheng County, especially the relationship between man and image, so as to combine nature protection with improving the lives of local people and accurately helping the poor.

　

Huang Xiaoming expressed condolences to farmers for emotional tears.

Thinking about the way of harmonious and sustainable development of human-image relationship　

　

According to the previous "fight against poverty — — According to the investigation results of the advance team of Operation Starlight, the activity area of wild elephants in Jiangcheng County is about 500 square kilometers, involving 93 villagers’ groups and more than 19,000 people of more than 4,800 households. The direct economic loss caused by wild elephants to the local people exceeds 40 million yuan, and the indirect loss is even more incalculable.

After the Asian elephant visit, Huang Xiaoming rushed to visit.The poor family in the whole wasteland group is a family that has been harassed by elephant group activities. Yang Xiaobao, a grandfather at home, is 87 years old this year, and his daughter is in poor health. Only his grandson Dao Lingqiu is left in the family, and several people rely on him to grow tea to feed.

When he arrived at the door of the poor people, Huang Xiaoming repeatedly said hello to everyone and gave them a thoughtful Mid-Autumn Festival gift. Grandpa grabbed his hand, and his simple emotion instantly infected Huang Xiaoming’s mood. He greeted "Grandpa" while holding each other tightly.

The house where the old people live is relatively old, the wooden beams have decayed and moth-eaten, and the sleeping place is often wet because of heavy rain and water leakage. On the table in the center of the main house, there are many medicine bags, which are the traditional Chinese medicine that mother Yang Huixian takes every day. For this family, which lacks labor, has a single source of income and an annual income of only 10,000 yuan, the monthly expenditure of nearly 1,000 yuan on medicine has caused a heavy economic burden. Since the establishment of archives in 2014, it has not yet achieved poverty alleviation. Talking about all kinds of difficulties, Yang Huixian and the children cried. Huang Xiaoming comforted them, but she couldn’t help crying.

Knowing that there are some problems in tea sales, such as poor promotion channels, poor popularity, and low sales price, Huang Xiaoming actively stated that he would use his own strength to help Jiangcheng County promote the tea industry and regard it as his second hometown: "Of course, my own strength is limited, and we will also use the’ tough battle against poverty — — Starlight Action’, let more people join in and find solutions together to help you solve your difficulties. "

This activity has attracted wide attention from all walks of life. The number of live viewers is nearly one million, and the number of topic discussions exceeds 47 million. Netizen’s message: "Thank you’ Starlight Action’, the outstanding Xiaoming brother, for supporting charity and guarding Yunnan."

　

After the investigation on 15th, Huang Xiaoming and his team will continue to learn more about the development of tea, nuts and other industries in Jiangcheng County on 16th.

　

　"Fighting poverty — — The whole activity of "Starlight Action" was broadcast exclusively by JD.COM, and supported by e-commerce platform for poverty alleviation. The whole event was sponsored by Huawei bracelet B5.

　 [Autohome car purchase manual] On February 27th, (|) was officially launched, positioning the medium-sized SUV, the new car guide price is 13.58-17 5,800 yuan, and a total of six models were launched. But unlike Haval Big Dog, the second-generation Big Dog provides two PHEV models, equipped with a gasoline-electric hybrid system composed of 1.5T + 2-speed DHT, and the official said that the comprehensive cruising range can exceed 1000 kilometers. Which of these models is the most suitable for purchase? Is the optional configuration and service worth it? Let’s take a look today.

A Brief Introduction to the Second Generation of Haval Big Dog

　 Haval’s second-generation big dog is relatively burly, and the new car is positioned as a medium-sized SUV. In terms of size, the length, width and height of Haval’s second-generation big dog are 4705/1908/1780mm respectively, and the wheelbase is 2810mm. Internal and external color manufacturers provide a variety of styles for you to choose from. There are five types of appearance colors, and all models can be selected, namely Greyhound, White Dog, Black Dog, Brown Dog, Orange Dog.Among these colors, individuals recommend brightly colored orange dogs, which are more in line with the tonality of the product and are very wild.

　 In terms of interior, the Chaoye version and the 50km Chaodian version only provide black interior, and all other Plus models can choose black, gray dumpling and black-brown interior.If you buy a PLUS model, the gray dumpling color is the most worth buying, which looks more upscale and luxurious.It is worth mentioning that there is no charge for exterior and interior color options

specific configuration analysis

　 Here comes the point!According to the difference in power, we are divided into two parts today to analyze for you, starting with the four gasoline models, followed by the PHEV version. After the configuration analysis, I found that the configuration of the four gasoline models of Haval’s second-generation big dog is very clear. You don’t need to look horizontally at it at all, let’s just chat vertically.In simple terms, all models with PLUS in the model name are: 1.5T Chaono Plus, 2.0T Chaono Plus, and 2.0T 4WD Chaono Plus. In addition to their different power forms, drive forms, and driving modes, all the configurations inside and outside the three cars are the same. Similarly, for models without Plus in the model name, the 2.0T Chaono version is actually the one with the lowest configuration. Let’s divide it into two parts for analysis.

Gasoline regular version: 2.0T Chaono version

　 Go ahead.Conclusion: Not recommended.The main reason is that it is much different from the 1.5T Chaono Plus in terms of configuration. At this level, the most important thing is cost performance. If I were to choose between a 2.0T + 9DCT powertrain, a low configuration, an expensive 2000 yuan and a 1.5T + 7DCT powertrain, a more comprehensive configuration, and a cheaper 2000 yuan, I would choose the latter.

　 In general, although the 2.0T Chaono version is the lowest matching model in terms of the actual internal and external configuration of the car, the complete degree of configuration is completely not inferior to the middle version of many models of the same level. In the power part, the 2.0T Chaono version is the same as the 2.0T Chaono version Plus and 2.0T four-wheel drive Chaono Plus, but the other two cars are more comprehensive in configuration. In addition to adding more configurations, the four-wheel drive system is also added.

Gasoline Plus Edition: 1.5T Tsuno Edition Plus, 2.0T Tsuno Edition Plus, 2.0T 4WD Tsuno Edition Plus

　 Let’s talk about the conclusion first: The most recommended purchase for all models is the 1.5T Chaono Edition Plus.First of all, it "entry is the top", whether it is 105km tide electric version Plus or 2.0T four-wheel drive tide wild Plus car has all the configurations, coupled with its very affordable price, only 135,800 yuan. Whether it is compared with the 105km tide electric version Plus priced at 175,800 yuan or the 2.0T four-wheel drive tide wild Plus priced at 156,800 yuan, its cost performance is still the highest.

　 The 1.5T + 7DCT version has actually been used for a long time on Haval Big Dog, and the owner’s reputation is also good, although the fuel consumption of this power system is slightly higher on the big dog. But on the second-generation big dog, compared with the more expensive or even more expensive 2.0T model and the more expensive hybrid model with tens of thousands of yuan, I think these are acceptable. After all, configuration, space and cost performance are what buyers of this level of model want most.

　 In the past, many car companies liked to lower the configuration of the lowest-equipped models, which was almost miserable, but in the past two years, many manufacturers have stopped doing this, and this time Haval is the same. The lowest-equipped models of the second-generation big dog are very high, achieving "entry-level top matching", you heard right! In addition to the differences in the power system and drive form, the lowest 1.5T Chaono Plus and 2.0T Chaono Plus, 2.0T four-wheel drive Chaono Plus and 105km Chaono Plus are completely the same, like electronic parking, 19-inch wheels, adaptive cruise, a full set of intelligent driver assistance systems, panoramic sunroof, induction trunk, keyless entry/start, and other configurations have appeared. Compared with the ordinary version of the model mentioned earlier, the Plus model has a lot more in terms of internal and external configuration.

　 Okay, the gasoline version has been analyzed. Here are the two versions of the PHEV. Although the name is very close to the gasoline version, there are still some differences in the configuration between the ordinary PHEV version and the Plus PHEV version. Let’s take a look.

Xinhua News Agency, Beijing, July 25 (reporter, Xu Bo) The General Administration of Quality Supervision, Inspection and Quarantine announced on the 25th that BMW (China) Automobile Trading Co., Ltd. and BMW Brilliance Automobile Co., Ltd. decided to recall some imported and domestic BMW 3 Series vehicles from August 25, totaling 15,474 vehicles.

The recalled vehicles include 1,877 BMW 3 Series vehicles imported by BMW (China) from June 1999 to August 2006, and 13,597 BMW 3 Series vehicles produced by BMW Brilliance from April 2003 to June 2005.

Due to the manufacturer’s manufacturing reasons, after some vehicles within the scope of this recall have been used in humid areas for a period of time, the front passenger side front airbag gas generator may malfunction, the airbag cannot be opened normally, and the metal shell of the gas generator is torn. There is a risk of injury to the front passenger or other occupants, and there is a safety hazard.

BMW (China) and BMW Brilliance will replace the front passenger side airbag module for vehicles within the scope of the recall free of charge to eliminate safety hazards. The two companies will proactively contact the relevant owners through authorized dealers to arrange repairs.

This week, a documentary about Edison Chen, "Within Reach," was viewed more than 10 million times on the Internet. Seven years after leaving the whirlpool of "pornographic photos," Edison Chen, 35, tells you that he has long stopped considering himself a star.

In the film, Edison Chen appears as a businessperson. He talks about his success in business and his attitude towards life. He bares his butt and waist to the camera and smiles wryly: "They all laugh at me for being out of shape, but I want to make money, not how to practice tendons."

But in fact, in the flashy entertainment industry, only this body of tendons has never been far away from him, and Edison Chen has persisted on the "runway" for a long time.

In order to complete the marathon, Edison Chen can quit smoking and train in the hot sun. Although running cannot be said to have reinvented him, at least running was once his "safe haven".

Chen Edison ran with his coach.

Warm up before running.

In hot weather, Edison Chen trained naked.

"Come on, we have to beat Teacher Chen"

When you have just finished watching Edison Chen in "Within Reach", you may find it hard to hide your disappointment. With thick bags under your eyes and a look like Uncle Benshan, the cream boy who once fascinated all beings in "Infernal Affairs" and "Thousand Machine Changes" is gone forever.

The only constant is Edison’s unruly attitude and his toned figure.

When Edison Chen fell into a trough, the first thing he "fell in love with" was running.

A sports brand once filmed a short film documenting Edison Chen’s sports life. During his two years in the United States, Edison Chen’s first thing after getting up every day was to run for more than an hour. He admitted that he started running because he was lost and could only escape reality by running.

"For more than two years, the first thing I do every day when I wake up is to run, 45 minutes to an hour." Gradually, running became his habit.

"Every run is a pleasant experience. If you are in a good mood, you will enjoy the process of running. If you are not in good condition, you have to keep running. After running, you will feel better. I don’t know that running can really stimulate inner energy, maybe it will become stronger…"

Chen Edison competed in the 10-kilometer race in Shanghai.

Xiao S teased Chen Edison’s clothes to see his abdominal muscles in "Kangxi is Coming".

On November 20, 2011, in a 10-kilometer race in Shanghai, Edison Chen ran 44 minutes and 27 seconds. You know, in the 2015 Shanghai Marathon 10-kilometer race, Liu Xiang’s 10-kilometer time was only about 50 minutes.

After that race, for a moment, "Come on, I want to beat Teacher Chen" became a pre-race greeting among male runners.

The 2012 Hong Kong Standard Chartered Marathon was Edison Chan’s first full marathon. Chen Edison said that in order to prepare for the start of his life, he ran three or four times a week. "I woke up at 5 am and went to bed at 10 pm. Although I didn’t officially try it out, I was confident to finish it."

According to Apple Daily, Chen decided to quit smoking during that training period. "You all know that running causes the body to release endorphins, which relaxes the body. I think I will enjoy the feeling of endorphins in the body."

In the end, Edison Chen finished the race in 3 hours and 55 minutes in Hong Kong, which is a rather good result for the amateur who challenged the first horse.

But according to the "Chongqing Evening News", ifeng.com and other media reports, because the number plate is not auspicious, Chen Edison and friends privately changed the number plate. Subsequently, the conference organizers received complaints from running friends and decided not to recognize Chen Edison’s achievements.

Chen Edison took a group photo with his grades.

Waiting in the crowd for departure.

"Problems come my way, falling makes me stronger"

After the Hong Kong Marathon, Chen Edison rarely participated in running competitions in public, but when it comes to running, Chen Edison can be regarded as a serious runner.

According to China News Service, in 2013, Taiwanese media photographed Chen Edison jogging alone in the stadium next to the Songshan Sports Center at noon, when the temperature was close to 40 degrees Celsius.

In a short running video shot by the sponsor, although there is a coach with him, he said that he still likes to run alone, whether in the morning or in the evening. "If it wasn’t for charity, I might not have gone to the marathon."

According to Apple Daily, Edison Chen’s first marathon has raised nearly one million Hong Kong dollars in donations.

Edison Chen said in his running documentary: "When you run, you don’t think about anything except your pace, and your whole head is in a state of emptiness." If you are on a treadmill, he will put on headphones, and you will be more attentive when you are in the music.

Chen Edison is preparing for the run.

Chen Edison also suffered sports injuries on the track, and was also given a health "yellow card" by the doctor.

"My feet hurt so much that I had to go to the doctor, but sometimes I was scared that the doctor would tell me not to run," Edison Chen said in the documentary. "Then I would be very sad."

In the documentary "Within Reach," Edison Chen said: "Those who keep saying that I am nothing, that I have achieved nothing, that I only rely on my face to eat, then they will have nothing to say. I have to thank them, they have given me a lot of strength."

Isn’t running power? As Edison Chen sings in his own song "Running":

"I don’t care about other people’s eyes, I only care about the front/Whether it works or not, facing the wind, what on earth do I have/I’m not afraid of failure, finally figured it out/The only exit is to go back/Forget all fears I don’t look back/Run, problems are coming/Falling makes me stronger…"

For more professional running fitness content, please pay attention to this column’s WeChat account: sijiabenpao or search the official account: private running.

　　[Aika Auto Domestic New Car Original]

　　Previously, the official released several brand-new (|) local official maps. Today, BYD’s brand-new official Qin EV map was officially released, and the new car still adopts the Dragon Face family-style front face. The overall design is not very different from the cash (|), which is dynamic and fashionable.

　　Judging from the official map released, the new car still adopts the latest Dragon Face family-style front face, and this design language has been well received by consumers. The headlight group has a higher degree of integration with the front middle net, and the overall sense is very strong. In addition, the headlight group adopts matrix design and contains five independent light sources, which makes it more recognizable.

　　In the rear part, the taillight group of the new car does not use the penetrating taillight that BYD is good at, but is connected with a chrome-plated decorative strip at the top, which is highly recognizable. In terms of body size, the length, width and height of the new car are 4675/1770/1500mm respectively, and the wheelbase is 2670mm. As for other relevant information, it has not been disclosed yet, and Aika will continue to pay attention.

　　Editor’s comment:(|) The sales volume of this model has always been very good, and its reputation among consumers is also commendable. Now the replacement model is coming, and I believe it will have better performance after listing in the future.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."